Intra-articular Vitamin D3 Injection for Patients With Temporomandibular Joint Osteoarthritis

MI-összefoglaló

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The trial is looking for adults with osteoarthritis of the jaw joint (temporomandibular joint, TMJ). They will get one joint injection of Vitamin D3 or salt water (placebo).

Életkor

18 years and older

Nem

All sexes

A betegség stádiuma

Jaw joint osteoarthritis as defined by the RDC/TMD criteria, Axis I, Group III.b.

Korábbi kezelés

People who have had jaw joint (TMJ) surgery before cannot join.

A részvétel fő kizáró okai

• Previous TMJ surgery
• Joint disease of a specific type, such as rheumatoid arthritis or psoriatic arthritis
• Pregnant women
• Breastfeeding women

A regiszter feltételei, szó szerint

Mit akar kideríteni a vizsgálat

The goal of this clinical trial is to evaluate the efficacy of intra-articular Vitamin D3 injection for the treatment of temporomandibular joint (TMJ) osteoarthritis. The main questions it aims to answer are: is intra-articular Vitamin D3 injection more effective than placebo in the treatment of temporomandibular joint osteoarthritis? . Does it improve secondary clinical outcomes such as pain-free mouth opening and remove TMJ sounds? Researchers will compare Vitamin D3 to a normal saline placebo group to see if intra-articular Vitamin D3 provides therapeutic benefits. Participants will:Undergo a diagnostic evaluation including a questionnaire, clinical examination, and MRI. Receive a single intra-articular injection of either 1 ml of Vitamin D3 (Cholecalciferol 200,000 IU) or 1 ml of normal saline into the superior joint compartment. Attend follow-up visits at two weeks, three months, and six months to assess pain scores, mouth opening, and presence of tmj sound.

A vizsgálat 2 csoportja

• Group will be injected with Vitamin D3Már használt kezelés, összehasonlításként

  Joint will be injected with 1ml of vitamin D3 ( Cholecalciferol 200.000 IU )

  Kezelés: Vitamin D3 (Cholecalciferol)

• Group will be injected with Normal SalinePlacebo, összehasonlításként

  Joint will be injected with 1ml of normal saline

  Kezelés: Normal Saline