Omega-3 fatty acids (fish oil) & Familial hypercholesterolaemia

Written from the studies on PubMed, searched on 11 Nov 2026. Every number below comes from a study listed under Sources.

What people read

Posts online say that Omega-3 fatty acids (fish oil) helps with Familial hypercholesterolaemia.

What has been studied

• 25In people21 randomised trials
• 9In animals
• 0Only in the lab

What the studies found

!Omega-3 fatty acids (fish oil) has been tested in randomised trials in people with Familial hypercholesterolaemia.

We found 45 published papers on Omega-3 fatty acids (fish oil) and Familial hypercholesterolaemia. They were published between 1988 and 2026.

25 of them are studies in people (21 randomised trials), 2 are reviews, 9 are studies in animals and 0 are studies only in the lab.

The most important ones are listed under Sources.

Sources

1. Effect of omega-3 fatty acid ethyl esters on postprandial arterial elasticity in patients with familial hypercholesterolemia.2023 · Clin Nutr ESPEN · Randomised trial
2. No effect of omega-3 polyunsaturated fatty acid supplementation on inflammatory markers in familial hypercholesterolemia: a randomized crossover trial.2023 · Scand J Clin Lab Invest · Randomised trial
3. Effect of Omega-3 Fatty Acid Supplementation on the Postprandial Metabolism of Apolipoprotein(a) in Familial Hypercholesterolemia.2023 · J Atheroscler Thromb · Randomised trial
4. Reduced gut microbial diversity in familial hypercholesterolemia with no effect of omega-3 polyunsaturated fatty acids intervention - a pilot trial.2022 · Scand J Clin Lab Invest · Randomised trial
5. Addition of marine omega-3 fatty acids to statins in familial hypercholesterolemia does not affect in vivo or in vitro endothelial function.2019 · J Clin Lipidol · Randomised trial
6. Effect of omega-3 fatty acid supplementation on arterial elasticity in patients with familial hypercholesterolaemia on statin therapy.2016 · Nutr Metab Cardiovasc Dis · Randomised trial
7. Effects of docosahexaenoic Acid supplementation on blood pressure, heart rate, and serum lipids in Scottish men with hypertension and hypercholesterolemia.2011 · Int J Hypertens · Randomised trial
8. Effects of prescription omega-3-acid ethyl esters on fasting lipid profile in subjects with primary hypercholesterolemia.2011 · J Cardiovasc Pharmacol · Randomised trial
9. Clinical importance of adherence to treatment with eicosapentaenoic acid by patients with hypercholesterolemia.2010 · Circ J · Study in people
10. Effects of addition of policosanol to omega-3 fatty acid therapy on the lipid profile of patients with type II hypercholesterolaemia.2005 · Drugs R D · Study in people
11. Dietary interventions (plant sterols, stanols, omega-3 fatty acids, soy protein and dietary fibers) for familial hypercholesterolaemia.2014 · Cochrane Database Syst Rev · Review
12. [Effect of omega-3-fatty acids on lipoprotein metabolism. Different effects in various phenotypes].1991 · Fortschr Med · Review
13. The Role of Fish Oil in Modulating Metabolic Disorders: Implications for Cardiovascular Health, Endothelial Dysfunction Biomarkers, and Hypercholesterolemia.2026 · Int J Prev Med · In animals
14. Synergistic anti-atherosclerotic role of combined treatment of omega-3 and co-enzyme Q10 in hypercholesterolemia-induced obese rats.2020 · Heliyon · In animals
15. Combination of Omega 3 and Coenzyme Q10 Exerts Neuroprotective Potential Against Hypercholesterolemia-Induced Alzheimer's-Like Disease in Rats.2020 · Neurochem Res · In animals
16. Apple flavonols and n-3 polyunsaturated fatty acid-rich fish oil lowers blood C-reactive protein in rats with hypercholesterolemia and acute inflammation.2014 · Nutr Res · In animals
17. Eicosapentaenoic acid in serum phospholipids relates to a less atherogenic lipoprotein profile in subjects with familial hypercholesterolemia.2013 · J Nutr Biochem · In animals
18. A fish-oil-rich diet reduces vascular oxidative stress in apoE(-/-) mice.2010 · Free Radic Res · In animals
19. Does fish oil supplementation increase cholesterol efflux capacity in familial hypercholesterolaemia?2023 · Eur J Clin Invest · Other paper
20. Icosapent Ethyl (Vascepa) for Hyperlipidemia/Hypercholesterolemia to Reduce Risk of Heart Attack and Stroke.2021 · Am Fam Physician · Other paper
21. Cost-Effectiveness of Statin Plus Eicosapentaenoic Acid Combination Therapy for Cardiovascular Disease Prevention in Japanese Patients With Hypercholesterolemia - An Analysis Based on the Japan Eicosapentaenoic Acid Lipid Intervention Study (JELIS).2018 · Circ J · Other paper
22. Does treatment with eicosapentaenoic acid prevent major coronary events in patients with hypercholesterolemia?2007 · Nat Clin Pract Cardiovasc Med · Other paper

Search PubMed yourself