Stem cell treatment & Familial hypercholesterolaemia

Written from the studies on PubMed, searched on 11 Nov 2026. Every number below comes from a study listed under Sources.

What people read

Posts online say that Stem cell treatment helps with Familial hypercholesterolaemia.

What has been studied

• 1In people
• 6In animals
• 11Only in the lab

What the studies found

!Stem cell treatment has been studied in people with Familial hypercholesterolaemia, but not in randomised trials.

We found 33 published papers on Stem cell treatment and Familial hypercholesterolaemia. They were published between 2004 and 2025.

1 of them are studies in people (0 randomised trials), 3 are reviews, 6 are studies in animals and 11 are studies only in the lab.

The most important ones are listed under Sources.

Sources

1. Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: studies in mice and FH children.2013 · Atherosclerosis · Study in people
2. [Human pluripotent stem cells and liver disorders].2016 · Biol Aujourdhui · Review
3. Using human-induced pluripotent stem cells to model monogenic metabolic disorders of the liver.2012 · Semin Liver Dis · Review
4. Severe hypercholesterolemia in patients with graft-vs-host disease affecting the liver after stem cell transplantation.2012 · Endocr Pract · Review
5. Hypercholesterolemia impairs collateral artery enlargement by ten-eleven translocation 1-dependent hematopoietic stem cell autonomous mechanism in a murine model of limb ischemia.2024 · JVS Vasc Sci · In animals
6. Hypercholesterolemia Accelerates the Aging Phenotypes of Hematopoietic Stem Cells by a Tet1-Dependent Pathway.2020 · Sci Rep · In animals
7. Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells.2017 · Stem Cell Reports · In animals
8. Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells.2017 · Cancer Res · In animals
9. Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells.2014 · J Am Heart Assoc · In animals
10. HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits.2011 · Biochem Biophys Res Commun · In animals
11. Establishment of a human induced pluripotent stem cell line from a patient with familial hypercholesterolemia carrying a frameshift mutation in LDLR gene.2025 · Stem Cell Res · In the lab
12. Generation of two familial hypercholesterolemia patient-specific induced pluripotent stem cell lines harboring heterozygous mutations in the LDLR gene.2024 · Stem Cell Res · In the lab
13. Induced pluripotent stem cell line ICGi037-A, obtained by reprogramming peripheral blood mononuclear cells from a patient with familial hypercholesterolemia due to heterozygous p.Trp443Arg mutations in LDLR.2022 · Stem Cell Res · In the lab
14. Induced pluripotent stem cell line ICGi038-A, obtained by reprogramming peripheral blood mononuclear cells from a patient with familial hypercholesterolemia due to compound heterozygous c.1246C > T/c.940 + 3_940 + 6del mutations in LDLR.2022 · Stem Cell Res · In the lab
15. Isogenic induced pluripotent stem cell line ICGi036-A-1 from a patient with familial hypercholesterolaemia, derived by correcting a pathogenic variant of the gene LDLR c.530C>T.2025 · Vavilovskii Zhurnal Genet Selektsii · Other paper
16. Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection.2019 · Stem Cell Res Ther · Other paper
17. Cholesterol efflux drives stem cell expansion in hypercholesterolaemia.2019 · Nat Rev Cardiol · Other paper
18. A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes.2018 · J Vis Exp · Other paper

Search PubMed yourself