Great Ormond Street Hospital

Running trials

• Not yet recruiting

  COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE"

  NCT07281027· Phase 3· Source

• Recruiting

  Prospective Natural History Study of POLG Disease

  NCT07775872· Source

• Recruiting

  A Clinical Study to Evaluate the Effects of NXT007 Compared to Emicizumab Prophylaxis in People With Hemophilia A

  NCT07416604· Phase 3· Source

• Recruiting

  DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.

  NCT07440290· Phase 2/3· Source

• Recruiting

  Obe-cel in Severe, Refractory Systemic Lupus Erythematosus (SLE) With Active Lupus Nephritis (LN)

  NCT07053800· Phase 2· Source

• Active, not recruiting

  A Study to Find Out How EMPAgliflozin is Tolerated and if it Helps Children and Adolescents With Chronic KIDNEY Disease (EMPA-KIDNEY® Kids)

  NCT07107945· Phase 3· Source

• Recruiting

  DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers.

  NCT05770544· Phase 2/3· Source

• Recruiting

  Multi-modular Chimeric Antigen Receptor T Cells tarGeting B7-H3 in Children, Teenage & Young Adult Sarcoma

  NCT07751380· Phase 1· Source

• Recruiting

  A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease, GM1 Gangliosidosis or GM2 Gangliosidosis

  NCT07054515· Phase 3· Source

• Recruiting

  A Study to Evaluate the Safety and Efficacy of Oral Nizubaglustat (AZ-3102) in Late-infantile and Juvenile Forms of Niemann-Pick Type C Disease (NPC)

  NCT07082725· Phase 3· Source

• Enrolling by invitation

  Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0

  NCT06823115· Source

• Recruiting

  Study of Olutasidenib and Temozolomide in HGG

  NCT06161974· Phase 2· Source

• Recruiting

  Gut Health in Children With Cancer

  NCT06899581· Source

• Recruiting

  A Multi-Arm, Platform Trial For Relapsed Neuroblastoma

  NCT07334301· Phase 1/2· Source

• Recruiting

  Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

  NCT05843253· Phase 2· Source

• Recruiting

  Targeted Pediatric High-Grade Glioma Therapy

  NCT05839379· Source

• Active, not recruiting

  Development and Validation of a New Paediatric Inflammatory Bowel Disease NUTrition Risk Score (PIBD-NUTS)

  NCT06723418· Source

• Recruiting

  A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome

  NCT05419492· Phase 1/2· Source

• Active, not recruiting

  A Clinical Study to Evaluate the Safety and Efficacy of ETX101, an AAV9-Delivered Gene Therapy in Children With SCN1A-positive Dravet Syndrome

  NCT06283212· Phase 1/2· Source

• Recruiting

  A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy (INSPIRE DUCHENNE)

  NCT06138639· Phase 1/2· Source

• Active, not recruiting

  Multi-modular Chimeric Antigen Receptor Targeting GD2 in Neuroblastoma

  NCT05990751· Phase 1· Source

• Recruiting

  A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease

  NCT05923073· Phase 3· Source

• Active, not recruiting

  Obe-cel in Adolescent [Applicable in UK Only] and Adult Severe, Refractory Systemic Lupus Erythematosus

  NCT06333483· Phase 1· Source

• Recruiting

  DETERMINE Trial Treatment Arm 01: Alectinib in Adult, Paediatric and Teenage/Young Adult Patients With ALK Positive Cancers

  NCT05770037· Phase 2/3· Source

• Recruiting

  DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition

  NCT05770102· Phase 2/3· Source

• Recruiting

  Determining the Mechanisms of Loss of CAR T Cell Persistence

  NCT05809284· Source

• Recruiting

  Study of Inebilizumab in Pediatric Subjects With Neuromyelitis Optica Spectrum Disorder

  NCT05549258· Phase 2· Source

• Recruiting

  DETERMINE Trial Treatment Arm 04: Trastuzumab in Combination With Pertuzumab in Adult, Paediatric and Teenage/Young Adult Patients With Cancers With HER2 Amplification or Activating Mutations

  NCT05786716· Phase 2/3· Source

• Recruiting

  DETERMINE (Determining Extended Therapeutic Indications for Existing Drugs in Rare Molecularly Defined Indications Using a National Evaluation Platform Trial) - Master Screening Protocol

  NCT05722886· Phase 2/3· Source

• Active, not recruiting

  Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-251 in Participants With Duchenne Muscular Dystrophy Amenable to Exon 51 Skipping

  NCT05524883· Phase 1/2· Source

• Recruiting

  A Pivotal Study of N-Acetyl-L-Leucine on Niemann-Pick Disease Type C

  NCT05163288· Phase 3· Source

• Active, not recruiting

  CiproPAL (Ciprofloxacin Prophylaxis in Acute Leukaemia)

  NCT04678869· Source

• Active, not recruiting

  A Long-term Extension Study of Ustekinumab in Pediatric Participants

  NCT05092269· Phase 3· Source

• Active, not recruiting

  A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors

  NCT04774718· Phase 1/2· Source

• Active, not recruiting

  A Study to Evaluate Tabelecleucel in Participants With Epstein Barr Virus (EBV) Associated Diseases

  NCT04554914· Phase 2· Source

• Recruiting

  High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

  NCT04221035· Phase 3· Source

• Active, not recruiting

  A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension

  NCT03492177· Phase 2· Source

• Active, not recruiting

  A Safety Study of Ustekinumab in the Treatment of Pediatric Participants Aged 6 Years and Older With Moderate to Severe Plaque Psoriasis

  NCT03218488· Source

• Active, not recruiting

  Paediatric Hepatic International Tumour Trial

  NCT03017326· Phase 3· Source

• Recruiting

  European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors

  NCT02813135· Phase 1/2· Source

• Recruiting

  CARPALL: Immunotherapy With CD19+CD22 CAR T-cells for CD19+ and CD22+ Acute Lymphoblastic Leukaemia

  NCT02443831· Phase 1· Source

• Active, not recruiting

  International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma

  NCT02066220· Phase 2/3· Source

• Recruiting

  Gaucherite - A Study to Stratify Gaucher Disease

  NCT03240653· Source

Recruiting at the same time

How many trials recruit for the same indication here at once. A count, not a rating.

• Childhood cancers16 recruiting
• Colorectal cancer3 recruiting
• Epilepsy3 recruiting
• Glioblastoma3 recruiting
• Melanoma3 recruiting
• Neuroblastoma3 recruiting
• Acute lymphoblastic leukaemia2 recruiting
• Lung cancer2 recruiting
• Ovarian cancer2 recruiting
• Acute myeloid leukemia1 recruiting
• Bladder cancer1 recruiting
• Chronic kidney disease1 recruiting
• Crohn's disease1 recruiting
• Duchenne muscular dystrophy1 recruiting
• Gaucher disease1 recruiting
• Haemophilia1 recruiting
• High blood pressure1 recruiting
• Kidney cancer1 recruiting
• Lupus (SLE)1 recruiting
• Multiple myeloma1 recruiting
• Neuromyelitis optica (NMOSD)1 recruiting
• Pancreatic cancer1 recruiting
• Prostate cancer1 recruiting
• Sarcoma1 recruiting
• Thyroid cancer1 recruiting

Researchers

No researcher is linked here yet.

Closed trials

• Recruiting

  A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)

  NCT05442567· Phase 3· Source

• Completed

  A Study of Ustekinumab or Guselkumab in Pediatric Participants With Active Juvenile Psoriatic Arthritis

  NCT05083182· Phase 3· Source

• Completed

  Evaluate Efficacy, Safety and Tolerability, PK and PD of Emapalumab in Children and Adults With MAS in Still's or SLE

  NCT05001737· Phase 3· Source

• Completed

  A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Ulcerative Colitis (UC)

  NCT04779307· Phase 3· Source

• Completed

  TT52CAR19 Therapy for B-cell Acute Lymphoblastic Leukaemia (B-ALL)

  NCT04557436· Phase 1· Source

• Completed

  Immunotherapy With Tacrolimus Resistant EBV CTL for Lymphoproliferative Disease After Solid Organ Transplant

  NCT03131934· Early phase 1· Source

• Completed

  Phase 1/2 Dose Finding and Safety Study of Ibrutinib in Pediatric Subjects With Chronic Graft Versus Host Disease (cGVHD)

  NCT03790332· Phase 1/2· Source

• Completed

  Arimoclomol Prospective Study in Participants Diagnosed With Niemann-Pick Disease Type C

  NCT02612129· Phase 2/3· Source

Trial sites

• Great Ormond Street Hospital47 trials
• Great Ormond Street Hospital - London1 trial
• Great Ormond Street Hospital (Pediatrics only)1 trial
• Great Ormond Street Hospital - PPDS1 trial
• Safari Day Care, Great Ormond Street Hospital1 trial

Conditions

Diseases this institution publishes on or runs trials for.

• Epilepsy69 works · 4 trials
• Childhood cancers32 works · 24 trials
• Spinal muscular atrophy19 works · 0 trials
• Neuroblastoma18 works · 4 trials
• Acute lymphoblastic leukaemia15 works · 4 trials
• Duchenne muscular dystrophy14 works · 2 trials
• Hypertrophic cardiomyopathy9 works · 0 trials
• Neuromyelitis optica (NMOSD)7 works · 1 trials
• Polycystic kidney disease3 works · 0 trials
• Retinitis pigmentosa3 works · 0 trials