Frontotemporal dementia: who works on it

One card per institution. Pick a target or a country to narrow the list.

• All targets
• TDP-43 4
• C9orf72 0
• MAPT 2
• TREM2 0
• CSF1R 0
• SOD1 0
• NRF2 0
• AKT 0
• APOE 0
• CDK4/6 0
• GLP-1 0
• HMGB1 0
• LRRK2 0
• MAPK 0
• NLRP3 0
• SIRT1 0
• SNCA 0
• STING 0
• TP53 0

1 of 1+ institutions, ordered by recent publications and open trials. This is not a ranking of quality.

Funded research projects that name this disease in their title, terms or summary and have not ended yet: who is funded, where, how much and until when. Organisations only; the funder's page has the details.

• European Commission (Horizon Europe) · HORIZON-TMA-MSCA-SE

  From Stool to Solutions: Diagnose, Decode, Disruptors, and Deliver Interventions for the Human Gut Microbiota in Neurodegenerative Diseases. (GUT-4D)

  Universita Degli Studi del Piemonte Orientale Amedeo Avogadro· Vercelli, Italy· EU contribution €1,568,130· until Sept 2030· 8 countries

  The disease is named only in the funder's project summary, not in the title.

• European Commission (Horizon Europe) · HORIZON-TMA-MSCA-PF-EF

  Unraveling the impact of RNA-editing in neurodegeneration: a focus on TDP-43 related frontotemporal dementia. (NeuroEDIT)

  Asociacion Instituto de Investigacion Sanitaria Biogipuzkoa· Donostia-San Sebastian, Spain· EU contribution €194,075· until Aug 2028· 2 countries

• European Commission (Horizon Europe) · HORIZON-TMA-MSCA-DN

  The role of cellular mechanical stress in the pathogenesis of neurodegenerative disorders (NEUROMECH)

  Universita Degli Studi Dell'aquila· L Aquila, Italy· EU contribution €2,647,675· until Dec 2029· 8 countries

  The disease is named only in the funder's project summary, not in the title.

• European Commission (Horizon Europe) · HORIZON-ERC

  Targeting rogue DNA repair and genomic instability as novel toxicity mechanisms in C9orf72 ALS/FTD (epiC9repair)

  Deutsches Zentrum fur Neurodegenerative Erkrankungen Ev· Bonn, Germany· EU contribution €2,498,905· until Oct 2030

• European Commission (Horizon Europe) · HORIZON-TMA-MSCA-SE

  Translational METabolomics for NEurodegenerative Diseases dIAgnosis and prognosis (METNEDIA)

  Universita Degli Studi del Piemonte Orientale Amedeo Avogadro· Vercelli, Italy· EU contribution €1,107,210· until Oct 2029· 5 countries

  The disease is named only in the funder's project summary, not in the title.

5 of 8 running projects, newest first. Listed amounts together: €17.7m.

Sources: NIH RePORTER (U.S. National Institutes of Health, public domain) and CORDIS (European Commission, CC BY 4.0). Changes: filtered by disease, organisations matched to ROR.

Terminated, withdrawn and suspended trials with the reason the sponsor gave in the registry, quoted word for word.

• Withdrawn

  Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders

  NCT01459302· University of Massachusetts, Worcester· Updated 19 Sept 2024

  “This study is not a clinical trial.”Registry text, quoted unchanged. Source

Trials whose registry record says individual participant data (IPD) will be shared.

No trial in this view states that it shares participant data.

Find publications on this disease by a MeSH method term, for example a sequencing or imaging method.

• Single-Cell Analysis 1
• Organoids 4
• Mendelian Randomization Analysis 10
• CRISPR-Cas Systems 1
• Gene Expression Profiling 4
• Whole Genome Sequencing 3
• Exome Sequencing 1
• Proteomics 17
• Metabolomics 1
• Mass Spectrometry 1
• Flow Cytometry 2
• Immunohistochemistry 1
• Positron-Emission Tomography 28
• Magnetic Resonance Imaging 74
• Machine Learning 18
• Deep Learning 9
• Cohort Studies 34
• Genome-Wide Association Study 13

• Genetic Prioritization of Plasma Proteins Across Dementia Subtypes: A Proteome-Wide Mendelian Randomization and Bayesian Colocalization Analysis.

  Cell Mol Neurobiol, Sept 2026

• Elucidating shared genetic signals between type 2 diabetes and three neurodegenerative dementia phenotypes.

  HGG Adv, Sept 2026

• Transcriptome-wide association analysis of Alzheimer's disease: construction and clinical validation of transcriptomic risk scores.

  Eur Arch Psychiatry Clin Neurosci, Aug 2026

• Exploring shared genetic pathways and gene interplay in major neurodegenerative diseases: a comprehensive review.

  Gene, Jul 2026

• Biobank-based genetic characterization of neurodegenerative diseases and idiopathic normal pressure hydrocephalus: insights and lessons learned from FinnGen.

  Mol Psychiatry, Jun 2026

• Association of telomere length with cognitive function and dementia: A cross-sectional NHANES analysis and 2-sample Mendelian randomization study.

  Medicine (Baltimore), Apr 2026

• A repeat expansion in GOLGA8A is a major risk factor for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.

  Nat Genet, Mar 2026

  Sonja W Scholz, Dennis W Dickson

• Polygenic associations with clinical and neuropathological trait heterogeneity across TDP-43 proteinopathies.

  PLoS One, Dec 2025

• Genetic Evidence Linking Lactylation-Related Gene Expression To Dementia Risk.

  Neuromolecular Med, Dec 2025

• Deep neural networks and genome-wide associations reveal the polygenic architecture of local brain aging.

  Geroscience, Dec 2025

See which targets of this disease your abstract mentions, and go to the people working on them.