Tai Ji Quan and Cognitive Function in Older Adults With Mild Cognitive Impairment
Key facts
- Who runs it
- Oregon Research Institute
- Where
- Eugene, United StatesSee the site
- Trial code
- Status
- Completed
- People taking part
- 318 people enrolled
- Started
- 15 Oct 2019
- Ended
- 30 Dec 2025
- Type of study
- Interventional, 3 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- The Go for Exercise & Healthy Aging Project
- Record updated
- 30 July 2026
Who can take part
- Age
- 65 years to 95 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 7 criteriaShow less
Who can take part
- complaint of memory loss
- clinical dementia rating (CDR) scale score ≤0.5
- having normal general cognitive function screened, with MMSE ≥24
- capable of exercising safely, as determined by a healthcare provider
- willingness to be randomly assigned to an intervention condition and complete the 24-week intervention and 6-month follow-up
Who cannot take part
- participating in any type of Tai Ji Quan or daily and/or structured vigorous physical activity (i.e., brisk walking for exercise 30 minutes or longer at a time, or engaging in muscle-strengthening activities, e.g., weight lifting on 3 or more days per week 3 months prior to the study)
- having medical conditions likely to compromise survival, such as metastatic cancer, or render a participant unable to engage in physical activity, such as severe cardiac failure
Where in United States
- Oregon Research InstituteEugene, United States
About the trial
What the trial wants to find out
To determine the efficacy of a cognitively enhanced exercise intervention - Tai Ji Quan: Moving to Maintain Brain Health in improving global cognitive function and dual-task ability in older adults with mild cognitive impairment.
The 3 groups in the trial
- Cognitively enhanced Tai Ji QuanTreatment being tested
Participants in this arm will exercise a series of Tai Ji Quan-based movements with configurations that are specifically designed for older adults to improve cognitive function, dual-task ability, strength/balance, and mobility.
Treatment: The Go for Exercise & Healthy Aging Project
- Standard Tai Ji QuanExisting treatment, for comparison
Serving as an active comparison arm, participants in this intervention will exercise a series of Tai Ji Quan-based movements that are specifically designed for older adults to improve strength/balance, cognitive function, and mobility.
Treatment: The Go for Exercise & Healthy Aging Project
- StretchingSham treatment, for comparison
Serving as a control arm, participants in this intervention will engage in a series of light exercise activities consisting of breathing, stretching, and body relaxation.
Treatment: The Go for Exercise & Healthy Aging Project
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Efficacy of Adapted Tai Ji Quan to Slow Cognitive Decline in Older Adults
- Publications
- Physical Activity Engagement After Tai Ji Quan Intervention Among Older Adults With Mild Cognitive Impairment or Memory Concerns: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open, 2024
- Clinical Effectiveness of Cognitively Enhanced Tai Ji Quan Training on Global Cognition and Dual-Task Performance During Walking in Older Adults With Mild Cognitive Impairment or Self-Reported Memory Concerns : A Randomized Controlled Trial.Annals of internal medicine, 2023
- A cognitively enhanced online Tai Ji Quan training intervention for community-dwelling older adults with mild cognitive impairment: A feasibility trial.BMC geriatrics, 2022
- Record updated
- 30 July 2026