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Active, not recruitingNo phase

MRI Following Stereotactic Radiosurgery (SRS) for Brain Metastases

Key facts

Who runs it
Duke University
Where
Durham, United StatesSee the site
Trial code
Status
Active, not recruiting
People taking part
25 people enrolled
Started
19 Jul 2021
Expected to end
24 Mar 2027
Type of study
Interventional
Treatments tested
  • MRI
Record updated
6 May 2026

Who can take part

Age
18 years and older
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 10 criteriaShow less

Who can take part

  • Adult patients, age ≥18
  • Metastatic malignancy with at least 1 brain metastasis previously treated with SRS
  • Patients may have also received whole brain radiation therapy (WBRT) for management of brain metastatic disease but this is not required for study participation
  • Patients must have been diagnosed with a metastatic solid tumor of any histological type except small cell lung cancer (SCLC), or lymphoma
  • Radiographic progression on post-SRS imaging at previously treated SRS site(s)
  • Must be a candidate for brain surgery as determined by treating neurosurgeon and/or anesthesia team
  • Patients must sign study-specific informed consent prior to study entry

Who cannot take part

  • Poor surgical candidate as determined by treating neurosurgeon and/or anesthesia team
  • Unable to undergo contrasted MRI (e.g. incompatible medical device, inadequate renal function per standard institutional clinical protocol, contrast allergy)
  • Small cell lung cancer (SCLC) or lymphoma histology

Where in United States

  • Duke University Health SystemDurham, United States

About the trial

What the trial wants to find out

The purpose of this study is to test whether an additional magnetic resonance image (MRI) sequence can improve the ability to distinguish radiation damage from tumor recurrence in participants with brain metastasis who have previously been treated with stereotactic radiosurgery (SRS).

The group in the trial

  • MRITreatment being tested

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Diagnostic Accuracy of Delayed MRI Contrast Enhancement Characteristics and Radiation Necrosis Following Stereotactic Radiosurgery (SRS) for Brain Metastases
Record updated
6 May 2026