Brain metastases trials in United States

In United States 91 Also abroad 217

91 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Collection of CSF Samples From Participants With Metastatic Triple Negative Breast Cancer (TNBC) and HER2+ Breast Cancer With no Prior History Nor Active Radiographically Detectable Brain Metastases
Where
Bethesda
Age
18 years to 120 years
People
139
Run by
National Cancer Institute (NCI)
See details and how to joinNCT07619534
Phase 4Taking people
Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer
Where
New York
Age
18 years and over
People
20
Run by
Weill Medical College of Cornell University
See details and how to joinNCT06072807
No phaseNot yet taking people in United States
Evaluating Biomarkers of Cognitive Dysfunction in Patients With Cancer
Where
San Francisco
Age
18 years and over
People
40
Run by
University of California, San Francisco
See details and how to joinNCT07226466
Phase 2Not yet taking people in United States
The METAMAX Study: MT027 Allogeneic CAR-T for Brain Metastases From Advanced Solid Tumors
Where
Houston
Age
18 years to 75 years
People
40 worldwide
Run by
T-MAXIMUM Pharmaceutical Inc
See details and how to joinNCT07897799
No phaseTaking people
REMASTer: REcurrent Brain Metastases After SRS Trial
Where
Baltimore, Chicago, Cleveland, Durham, Kettering, Los Angeles, Milwaukee, St Louis, Winston-Salem
Age
18 years and over
People
261
Run by
Monteris Medical
See details and how to joinNCT05124912
No phaseTaking people
Circulating Biomarkers Repository in Adults Diagnosed With Primary and Metastatic Brain Tumors
Where
Durham
Age
18 years and over
People
300
Run by
Duke University
See details and how to joinNCT05480644
No phaseTaking people
Development of MRF for Characterization of Brain Tumors After Radiotherapy
Where
Cleveland
Age
18 years to 60 years
People
90
Run by
Case Comprehensive Cancer Center
See details and how to joinNCT06101069
Phase 1Taking people
IL-8 Receptor Modified Patient-Derived Activated CD70 CAR T Cell Therapy in Adults With Brain Metastases
Where
Gainesville
Age
18 years to 80 years
People
12
Run by
University of Florida
See details and how to joinNCT07569263
Phase 3Taking people
Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets
Where
Baltimore, Durham, Fort Lauderdale, Miami, Newport Beach, Phoenix, Pittsburgh, Portland, Providence, Richmond, Tampa, Winston-Salem
Age
18 years to 100 years
People
96 worldwide
Run by
InSightec
See details and how to joinNCT05317858
Phase 1/2Taking people
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Where
Aurora, Boston, Cleveland, Durham, Fairfax, Gilbert, Grand Rapids, Houston, Los Angeles, Minneapolis, Nashville, New Haven, New York, San Antonio, San Francisco, Seattle, St Louis, Washington D.C.
Age
18 years and over
People
554 worldwide
Run by
Institut de Recherches Internationales Servier
See details and how to joinNCT05786924 · EU 2025-523474-16-00
Early phase 1Taking people
Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases
Where
Atlanta
Age
18 years and over
People
10
Run by
Emory University
See details and how to joinNCT06328686
Phase 1/2Taking people
Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study
Where
Cleveland
Age
18 years and over
People
36
Run by
Case Comprehensive Cancer Center
See details and how to joinNCT01891318
Phase 1/2Taking people
Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer
Where
Boston, Centerville, Detroit, Fullerton, Houston, Los Angeles, Nashville, Norfolk, Portland, San Antonio, Urbana
Age
18 years and over
People
73 worldwide
Run by
Stemline Therapeutics, Inc.
See details and how to joinNCT05386108 · EU 2024-512878-98-00
Phase 2Taking people
Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases
Where
Houston
Age
18 years and over
People
104
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT05064280
Phase 2Taking people
EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active
Where
Houston
Age
18 years and over
People
316
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06649058
Phase 1Not yet taking people in United States
Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases
Where
Miami
Age
18 years and over
People
20
Run by
Baptist Health South Florida
See details and how to joinNCT07454668
Phase 1/2Taking people
SRS & Abemaciclib w/wo Imlunestrant in the Management of HR+/HER2- Breast CA Brain Metastases
Where
Columbus, Tampa
Age
18 years and over
People
31
Run by
H. Lee Moffitt Cancer Center and Research Institute
See details and how to joinNCT04923542
Phase 1/2Taking people
Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
Where
Beverly Hills, Boston, Boynton Beach, Dallas, Glendale, Los Angeles, Nashville, Tacoma
Age
18 years and over
People
134
Run by
Neonc Technologies, Inc.
See details and how to joinNCT06047379
Phase 2Taking people
Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)
Where
Cleveland
Age
18 years and over
People
90
Run by
Case Comprehensive Cancer Center
See details and how to joinNCT07248228
Early phase 1Taking people
Feasibility of 18F-Fluciclovine PET/CT to Identify Brain Metastasis
Where
Tucson
Age
18 years to 99 years
People
20
Run by
University of Arizona
See details and how to joinNCT06055790
Phase 2Taking people
A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain Metastases
Where
Houston
Age
18 years and over
People
20
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT05048212
Phase 2Taking people
Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM)
Where
Houston
Age
18 years and over
People
155
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT07053033
Phase 2Taking people
Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)
Where
Charleston
Age
18 years and over
People
54
Run by
Medical University of South Carolina
See details and how to joinNCT07227610
No phaseTaking people
PilotStudyAssessSafeActiveSurveillancApproachLocalThe Pa w/BrainMetsUndergoinCNSPenetratSystemicThe
Where
Orange
Age
18 years and over
People
12
Run by
University of California, Irvine
See details and how to joinNCT07827001
Phase 2Taking people
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
Where
Aberdeen, Alton, Ames, Anaconda, Anchorage, Ann Arbor, Antigo, Aurora, Aventura, Baker City, Ballwin, Battle Creek, Beachwood, Beavercreek, Bellingham, Belpre, Bend, Billings, Birmingham, Bloomington, Boardman, Boise, Bolivar, Boone, Boulder, Bozeman, Branson, Brighton, Buffalo, Burbank, Burnsville, Caldwell, Cambridge, Canton, Cape Girardeau, Carbondale, Carroll, Carterville, Carthage, Centennial, Centerville, Centralia, Chardon, Cheyenne, Chicago, Chillicothe, Cincinnati, Clackamas, Clemmons, Cleveland, Clinton, Cody, Coeur d'Alene, Columbus, Coon Rapids, Coos Bay, Coral Gables, Danville, Dayton, Decatur, Deerfield Beach, Delaware, Denver, Des Moines, Dixon, Dublin, Eau Claire, Edina, Edmonds, Effingham, Emeryville, Emmett, Englewood, Eureka, Everett, Fairbanks, Fairhope, Farmington, Findlay, Fort Dodge, Fort Smith, Franklin, Fridley, Fruitland, Gahanna, Galesburg, Garden City, Goldsboro, Grand Rapids, Great Bend, Great Falls, Greeley, Greenville, Grove City, Issaquah, Jacksonville, Jefferson, Jefferson City, Joplin, Kalamazoo, Kalispell, Kennewick, Kettering, Kewanee, Lacey, La Crosse, Lake Forest, Lakewood, Lancaster, Lima, Lincoln, Littleton, Lone Tree, Longview, Los Angeles, Loveland, Macomb, Madison, Mansfield, Maple Grove, Maplewood, Marietta, Marion, Marshalltown, Marshfield, Martinez, Medford, Meridian, Miami, Middleburg Heights, Minneapolis, Minocqua, Missoula, Mobile, Monticello, Mount Vernon, Muskegon, Nampa, Napa, New Albany, Newark, Newberg, New Richmond, New Ulm, Niles, Norton Shores, Oakland, O'Fallon, Oklahoma City, Ontario, Oregon City, Orlando, Ottawa, Paducah, Parma, Pekin, Peoria, Perrysburg, Peru, Pittsburgh, Plantation, Portland, Portsmouth, Port Townsend, Post Falls, Princeton, Ravenna, Redmond, Reed City, Rice Lake, Richmond, Robbinsdale, Rolla, Sainte Genevieve, Saint Joseph, Saint Louis Park, Saint Paul, Salt Lake City, San Diego, Sandpoint, Sandusky, Santa Rosa, Savannah, Seattle, Sedro-Woolley, Shakopee, Shelton, Sheridan, Sioux Falls, Springfield, Statesville, Stevens Point, Stillwater, St Louis, Sullivan, Sunset Hills, Swansea, Tampa, Thornton, Toledo, Traverse City, Troy, Twin Falls, Urbana, Vancouver, Waconia, Wadsworth, Walla Walla, Walnut Creek, Warren, Washington, Wausau, West Chester, West Des Moines, Westerville, Westlake, Weston, Wilkesboro, Willmar, Winston-Salem, Wisconsin Rapids, Woodbury, Wyoming, Yelm, Yorkville, Youngstown, Zanesville
Age
18 years and over
People
112
Run by
SWOG Cancer Research Network
See details and how to joinNCT04511013