Cognitive Fitness for Depression in Older Adults
Key facts
- Who runs it
- UConn Health
- Where
- Farmington, United StatesSee the site
- Trial code
- Status
- Completed
- People taking part
- 38 people enrolled
- Started
- 15 Nov 2020
- Ended
- 15 Oct 2024
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Computerized Cognitive Remediation of Executive Functioning (CCR-EF)
- Active Control
- Record updated
- 29 April 2026
Who can take part
- Age
- 60 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- ability to read and write in English
- current major or mild depression despite ongoing treatment
- under the care of a physician who prescribes medication for depression
- currently treated with an antidepressant for at least 8 weeks
Who cannot take part
- substance use disorders in the prior year
- other psychiatric disorders (except personality \& generalized anxiety disorders)
- clinical diagnosis of dementia
- neurological disorders (e.g., stroke, epilepsy, brain injury with loss of consciousness > 30 minutes, brain tumors, demyelinating diseases)
- psychosis
- corrected visual acuity < 20/70 or color blindness
Where in United States
- UConn HealthFarmington, United States
About the trial
What the trial wants to find out
This research is being done to determine if computerized administered cognitive fitness activities will improve thinking and depression in older depressed adults who are being treated with antidepressants. The investigators are also interested in whether participating in the treatment will result in changes to brain activity measured with magnetic resonance imaging (MRI).
The 2 groups in the trial
- Computerized Cognitive Remediation of Executive Functioning (CCR-EF)Treatment being tested
Initially 10 hours of processing speed exercises from "Brain HQ", (the 3 exercises are auditory tone sweep, visual processing \[Double Decision\], visual sweep). Following the 8-10 hours of Brain HQ, participants complete 8-10 hours of "Ultimate Word Master" before completing 16-20 hours of "Neurogrow" (formerly called "Catch the Ball"). Participants are asked to complete approximately 28-42 hours of computerized brain training over 4-6 weeks.
- Active ControlExisting treatment, for comparison
Patients in the active control arm will complete three activities according to a standard protocol: 1) play a visuospatially oriented computer game (Myst), 2) watch computer-based educational programs on art, history, literature, and 3) play computer games online through the Brain HQ platform; games include crossword puzzles, soduko, paddleboard, and word search. Participants will complete a total of 32-42 hours of training over 4-6 weeks. Time spent on each task will be evenly divided (15 minutes of each task everday).
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Cognitive Remediation of Cognitive Control in Late-Life Depression
- Record updated
- 29 April 2026