Studying heart muscle disease using genetics, imaging and blood samples over time
Follows people with cardiomyopathy or possible genetic risk, collecting blood samples and health data.
Plain-language title generated from the registry record
Registry title: The SMARTER Cardiomyopathy Study
Key facts
- Where
- London, United KingdomSee the 2 sites
Where in United Kingdom
- Guys St Thomas NHS Foundation TrustLondon, United KingdomTaking people
- Kings College HospitalLondon, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Imperial College London
- Trial code
- NCT05750147
- Record updated
- 6 March 2024
- Original description
Cardiomyopathies are diseases of the heart muscle. Known genetic factors may account for some cardiomyopathy cases but there is still much to understand about the genetic and environmental causes and how the disease progresses.Read full original descriptionShow less
Genetics, Imaging and Artificial Intelligence for Precision Care in Cardiomyopathy
Cardiomyopathies are diseases of the heart muscle. Known genetic factors may account for some cardiomyopathy cases but there is still much to understand about the genetic and environmental causes and how the disease progresses.
Finding new ways to diagnose and treat cardiomyopathies could improve the health and well-being of patients with these conditions.
This study will collect data from individuals with cardiomyopathy or related heart muscle disease, or with a possible genetic predisposition to cardiomyopathy, and follow them over time to observe the progress of their heart and health. This study will collect DNA, blood samples, and detailed clinical \& lifestyle information at the start of the study, and data collected during routine healthcare visits over time.
* learn what causes cardiomyopathy, and therefore how to treat it * understand why cardiomyopathy progresses differently in different people, to improve the ability to recognise who will benefit from different treatments at different times
The investigators will collaborate with other centres internationally to collect a large of group of participants with similar cardiomyopathies, providing power to identify new pathways that cause disease and ways of predicting which participants are at risk of having more severe disease.
Inclusion: Adults with the capacity to consent Children with parental/guardian consent Male and Female; Meeting the following criteria:; Patients with a confirmed diagnosis of cardiomyopathy or related condition; Patients with a family member with cardiomyopathy, or a related condition; Patients with a genetic variant that may predispose to cardiomyopathy, or a related condition.
Exclusion: Patients without the capacity to provide informed consent.