Studying heart muscle disease using genetics, imaging and blood samples over time
Follows people with cardiomyopathy or possible genetic risk, collecting blood samples and health data.
Key facts
- Who runs it
- Imperial College London
- Where
- London, United KingdomSee the 2 sites
- Trial code
- Registry title
- The SMARTER Cardiomyopathy Study
- Status
- Recruiting
- People taking part
- 1,000 people, planned
- Started
- 1 Mar 2023
- Expected to end
- 1 Aug 2027
- Type of study
- Observational
- Treatments tested
- Blood Sample Collection
- Record updated
- 6 March 2024
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people with cardiomyopathy or a related heart muscle disease. It also looks for people with a relative who has it, or with a gene change that may raise the risk.
- Age
- Adults and children. Children need consent from a parent or guardian.
- Sex
- Men and women can join.
- Disease stage
- A confirmed cardiomyopathy or a related condition, a family member with it, or a gene change that may lead to it.
- Biomarker or test result
- A genetic variant that may predispose to cardiomyopathy or a related condition (one of the ways to join).
Main reasons for not taking part
- People who cannot give informed consent themselves cannot join.
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- Adults with the capacity to consent Children with parental/guardian consent Male and Female
- Meeting the following criteria:
- Patients with a confirmed diagnosis of cardiomyopathy or related condition
- Patients with a family member with cardiomyopathy, or a related condition
- Patients with a genetic variant that may predispose to cardiomyopathy, or a related condition
Who cannot take part
- Patients without the capacity to provide informed consent
Where in United Kingdom
- Guys St Thomas NHS Foundation TrustLondon, United KingdomContact: Study CoordinatorTaking people
- Kings College HospitalLondon, United KingdomContact: Study CoordinatorTaking people
About the trial
What the trial wants to find out
Cardiomyopathies are diseases of the heart muscle. Known genetic factors may account for some cardiomyopathy cases but there is still much to understand about the genetic and environmental causes and how the disease progresses.
Read full original descriptionShow less
Finding new ways to diagnose and treat cardiomyopathies could improve the health and well-being of patients with these conditions.
This study will collect data from individuals with cardiomyopathy or related heart muscle disease, or with a possible genetic predisposition to cardiomyopathy, and follow them over time to observe the progress of their heart and health. This study will collect DNA, blood samples, and detailed clinical \& lifestyle information at the start of the study, and data collected during routine healthcare visits over time.
* learn what causes cardiomyopathy, and therefore how to treat it * understand why cardiomyopathy progresses differently in different people, to improve the ability to recognise who will benefit from different treatments at different times
The investigators will collaborate with other centres internationally to collect a large of group of participants with similar cardiomyopathies, providing power to identify new pathways that cause disease and ways of predicting which participants are at risk of having more severe disease.
The group in the trial
- Cardiomyopathies
Approximately 1000 participants recruited prospectively from participating sites with a diagnosis of cardiomyopathy Participants will provide biosamples and allow access to medical scans and records for health data collection
Treatment: Blood Sample Collection
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Genetics, Imaging and Artificial Intelligence for Precision Care in Cardiomyopathy
- Plain-language title
- Studying heart muscle disease using genetics, imaging and blood samples over timeGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 6 March 2024