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Taking people in United StatesNo phase

Personalized Tobacco Treatment in Primary Care (MOTIVATE)

Key facts

Who runs it
Washington University School of Medicine
Where
St Louis, United StatesSee the site
Trial code
Status
Recruiting
People taking part
850 people, planned
Started
29 Sept 2023
Expected to end
30 Sept 2028
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • Precision Treatment
  • Usual Care
Record updated
3 November 2026

Who can take part

Age
18 years and older
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 12 criteriaShow less

Other criteria

  • Eligibility Criteria for Primary and Specialty Care Clinicians
  • Clinician from participating clinic
  • At least 18 years of age
  • Can speak and understand English; Eligibility Criteria for Primary Care and Specialty Patients; Inclusion:
  • Patient at participating clinic
  • Age 18 years or older, inclusive
  • Current smoking (cigarettes per day >=5)
  • Can speak and understand English
  • Willing to consider medication to help reduce craving or smoking such as nicotine patch, lozenge, or varenicline; Exclusion:
  • Active use of smoking cessation medication (within the past 30 days)
  • Receipt of smoking cessation medication or prescription for smoking cessation medication (within the past 30 days)
  • Having a contraindication for cNRT or varenicline (allergic reactions, current cardiac problems, pregnancy)

Where in United States

  • Washington University School of MedicineSt Louis, United StatesContact: Li-Shiun Chen, ScD, MD, MPHTaking people

About the trial

What the trial wants to find out

This study examines the application of precision treatment intervention for smoking cessation from both the clinician perspective and patient perspective, and compares it to usual care on tobacco treatment in the primary care setting. The precision treatment intervention includes personalized tobacco treatment recommendations using the patient's clinical, genetic, and biomarker information. This approach may increase effectiveness and adherence for the patient, and increase the clinician's likelihood of prescribing.

The 2 groups in the trial

  • Usual CareExisting treatment, for comparison

    The arm will represent usual care in the primary care clinics. Physicians will receive a report designed to recommend guideline-based tobacco treatment. Patients will receive a report on guideline-based advice about smoking cessation and a brief discussion with a behavior interventionist.

  • PrecisionTxTreatment being tested

    Physicians will receive PrecisionTx, an intervention designed to recommend precision tobacco treatment. Patients will receive PrecisionTx, an intervention designed to recommend precision tobacco treatment, and a brief discussion with a behavior interventionist.

    Treatment: Precision Treatment

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
A Multilevel Intervention to Personalize and Improve Tobacco Treatment in Primary Care (MOTIVATE)
Record updated
3 November 2026