Smoking and nicotine dependence trials in United States

In United States 164 Also abroad 266

164 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Rural Smoking Cessation
Where
Durham, Minneapolis
Age
21 years and over
People
544
Run by
Masonic Cancer Center, University of Minnesota
See details and how to joinNCT06584929
No phaseTaking people
Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging
Where
Baltimore
Age
18 years to 80 years
People
1,000
Run by
National Institute on Drug Abuse (NIDA)
See details and how to joinNCT01036581
Phase 4Taking people
Using Multiphase Optimization Strategy (MOST) to Optimize a Cost-effective, Sustainable and Scalable Smoking Cessation Package for Smokers in HIV Clinical Care
Where
New York
Age
18 years and over
People
500
Run by
New York University
See details and how to joinNCT06598397
No phaseNot yet taking people in United States
Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation
Where
Minneapolis
Age
18 years and over
People
30
Run by
University of Minnesota
See details and how to joinNCT07789496
Phase 4Taking people
My Path to Quit Tobacco
Where
Indianapolis, Kansas City, Milwaukee, Phoenix, Richmond
Age
21 years and over
People
1,550
Run by
University of Wisconsin, Madison
See details and how to joinNCT07419425
Phase 2Taking people
Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation
Where
Oklahoma City
Age
18 years and over
People
496
Run by
University of Oklahoma
See details and how to joinNCT07099638
No phaseTaking people
Optimizing Medications and Lung Health in People With HIV Through Pharmacist-led Proactive E-Consults
Where
Boise, Minneapolis, Seattle
Age
18 years and over
People
480
Run by
Seattle Institute for Biomedical and Clinical Research
See details and how to joinNCT07507435
No phaseTaking people
Scalable TELeheaLth Cancer CARe: The STELLAR Program to Treat Cancer Risk Behaviors
Where
Chicago
Age
18 years and over
People
1,500
Run by
Northwestern University
See details and how to joinNCT05687604
Phase 3Taking people
Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT)
Where
Austin, Brooklyn, Columbus, Dallas, DeLand, Duncansville, Evansville, Fort Worth, Huston, Jacksonville, Kansas City, Knoxville, Lemon Grove, Little Rock, Long Beach, Memphis, Mount Airy, Nashville, Newport News, North Charleston, Orlando, Phoenix, Pomona, Rochester, Skokie, Stockbridge, Tampa
Age
18 years to 65 years
People
705
Run by
Axsome Therapeutics, Inc.
See details and how to joinNCT07766655
No phaseNot yet taking people in United States
Impacto 2.0: Mobile Smoking Cessation Across Texas
Where
Houston
Age
18 years and over
People
100
Run by
Michael J. Zvolensky, Ph.D.
See details and how to joinNCT07915973
No phaseTaking people
Young Adult Tobacco/Nicotine and Cannabis Co-use
Where
Charleston
Age
18 years to 25 years
People
350
Run by
Medical University of South Carolina
See details and how to joinNCT06239350
No phaseTaking people
Social Media Support Groups for Adolescent Vaping Cessation
Where
San Francisco
Age
13 years and over
People
60
Run by
University of California, San Francisco
See details and how to joinNCT07540780
No phaseTaking people
Personalized Tobacco Treatment in Primary Care (MOTIVATE)
Where
St Louis
Age
18 years and over
People
850
Run by
Washington University School of Medicine
See details and how to joinNCT05846841
Phase 3Not yet taking people in United States
iCanQuit Smoking Cessation Among Hispanic Adults
Where
Seattle
Age
18 years and over
People
854
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT06811038
No phaseTaking people
Developing an E-Cigarette Cessation Intervention for Hispanic/Latina(o) Youth in Florida: The BReATHE Study
Where
Miami
Age
14 years to 18 years
People
120
Run by
Florida International University
See details and how to joinNCT07192601
No phaseNot yet taking people in United States
Contingency Management to Promote Smoking Cessation Study
Where
Kansas City
Age
18 years and over
People
40
Run by
University of Kansas Medical Center
See details and how to joinNCT07685899
No phaseTaking people
Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies
Where
New York
Age
18 years and over
People
2,000
Run by
Weill Medical College of Cornell University
See details and how to joinNCT01776398
No phaseTaking people
Precision Treatment to Promote Smoking Cessation and Survival in Oncology Patients
Where
St Louis
Age
18 years to 89 years
People
132
Run by
Washington University School of Medicine
See details and how to joinNCT07166120
No phaseTaking people
Project Q: Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly or Non-daily
Where
Durham
Age
18 years and over
People
60
Run by
Duke University
See details and how to joinNCT07425119
No phaseTaking people
Use of Nicotine Pouches Among Daily Smokers
Where
Hershey, Houston
Age
21 years to 70 years
People
375
Run by
Milton S. Hershey Medical Center
See details and how to joinNCT06043362
No phaseNot yet taking people in United States
A Smartphone Application (QuitBot) for the Improvement of Smoking Cessation Among American Indians and Alaska Natives, NAITIVE Trial
Where
Seattle
Age
18 years and over
People
772
Run by
Fred Hutchinson Cancer Center
See details and how to joinNCT06697496
Phase 4Not yet taking people in United States
Varenicline for Smoking Cessation in Pancreatitis
Where
Rochester
Age
18 years and over
People
45
Run by
Mayo Clinic
See details and how to joinNCT07874841
No phaseTaking people
Facilitation to Increase Tobacco Treatment
Where
Baltimore
People
65
Run by
VA Office of Research and Development
See details and how to joinNCT07455526
No phaseNot yet taking people in United States
ChatGPT-Supported Text Messaging Program for Smoking Cessation
Where
Washington D.C.
Age
18 years and over
People
180
Run by
George Washington University
See details and how to joinNCT07079306
No phaseTaking people
Impact of Novel vs. Usual Brand Menthol Cigarettes on Abuse Liability
Where
Columbus
Age
21 years and over
People
48
Run by
Ohio State University Comprehensive Cancer Center
See details and how to joinNCT07564648