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Smoking and nicotine dependence

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Where research stands todayUpdated 15 Nov 2026
Trial-stage treatments you can join–open now
in United States
Studies published in the last 12 months00 in people · 0 in animals · 0 in the lab
Support organisations2organisations
in United States1 helpline
Offer tissue or dataGive a sample or your health data to research.Approved treatmentsMedicines approved for smoking and nicotine dependence around the world.“Miracle cure” fact checkerSaw a cure online? Check it before you pay.

Trial-stage treatments and research studies you can join

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Get notified of new trialsUnited States, all cities, all phases
Your ageShows only trials that take people your age.
Phase
  1. Trial-stage treatmentTaking people
    Clinical trial: Nicoderm CQ nicotine patch, Nicorette Nicotine Lozenges
    Durham, United StatesAlso MinneapolisAge 21+
  2. Trial-stage treatmentTaking people
    Clinical trial: MagPro X100 Magnetic Stimulator, Transcranial Rotating Magnetic Stimulator, Magnetom Prisma Fit 3T Scanner
    Baltimore, United StatesAge 18 to 80
  3. Trial-stage treatmentPhase 4Taking people
    Testing smoking quit support for people with HIV in clinic care

    Tests ways to help smokers living with HIV quit smoking during HIV clinic visits.

    New York, United StatesAge 18+
  4. Trial-stage treatmentPhase 4Taking people
    Phase 4 trial: Nicotine patch
    Indianapolis, United StatesAlso Kansas City, Milwaukee, Phoenix, RichmondAge 21+
  5. Trial-stage treatmentPhase 2Taking people
    Phase 2 trial: Varenicline (VAR), Nicotine lozenge (NRT)
    Oklahoma City, United StatesAge 18+
  6. Trial-stage treatmentPhase 3Taking people
    Phase 3 trial: AXS-05 (dextromethorphan-bupropion), Bupropion
    Austin, United StatesAlso Brooklyn, Columbus, Dallas, DeLand, Duncansville, Evansville, Fort Worth, Jacksonville, …Age 18 to 65
  7. Trial-stage treatmentPhase 3Soon in United States
    Phase 3 trial: iCanQuit Smartphone App Smoking Cessation Program, Nicotine Gum, Nicotine Patch
    Seattle, United StatesAge 18+
  8. Trial-stage treatmentSoon in United States
    Clinical trial: QuitBot Smoking Cessation Chatbot Program, QuitBot Smoking Cessation Text Messaging Program
    Seattle, United StatesAge 18+
  9. Trial-stage treatmentPhase 4Soon in United States
    Phase 4 trial: Varenicline (VAR)
    Rochester, United StatesAge 18+
  10. Trial-stage treatmentPhase 4Taking people
    Phase 4 trial: Bupropion Hydrochloride Controlled-release, Nicotine Replacement, Varenicline
    Houston, United StatesAge 18+
  11. Trial-stage treatmentPhase 4Taking people
    Phase 4 trial: Varenicline, Nicotine patch
    Madison, United StatesAge 21+
  12. Trial-stage treatmentPhase 2/3Taking people
    Phase 2/3 trial: Non-invasive vagus nerve stimulator plus nicotine…, nicotine replacement patches
    Rochester, United StatesAge 18+
  13. Trial-stage treatmentPhase 4Soon in United States
    Medication and Financial Rewards to Help People With HIV Quit Smoking

    Tests quit-smoking medicines plus financial rewards in adults with HIV who smoke.

    Bridgeport, United StatesAlso Brooklyn, Jersey City, New Haven, PatersonAge 18+
  14. Trial-stage treatmentPhase 2Taking people
    Semaglutide to Limit Weight Gain After Quitting Smoking

    Tests semaglutide in adults with overweight or obesity who are quitting smoking.

    Austin, United StatesAlso HoustonAge 18 to 75
  15. Trial-stage treatmentTaking people
    Magnetic brain stimulation to help people with schizophrenia quit smoking

    Tests two magnetic brain stimulation coils in adults with schizophrenia who smoke.

    Houston, United StatesAge 22 to 65
  16. Trial-stage treatmentPhase 4Taking people
    Phase 4 trial: Varenicline, Transcranial Magnetic Stimulation, D-cycloserine
    Boston, United StatesAge 18 to 65
  17. Trial-stage treatmentTaking people
    Clinical trial: Belsomra, Methylphenidate
    Baltimore, United StatesAge 18 to 60
  18. Trial-stage treatmentTaking people
    Clinical trial: TI-NDBS
    Bloomington, United StatesAlso IndianapolisAge 21 to 50
  19. Trial-stage treatmentTaking people
    Clinical trial: PRIME TMS, Standard TMS
    Newark, United StatesAge 18 to 60
  20. Trial-stage treatmentPhase 1/2Taking people
    Phase 1/2 trial: Nicotine Replacement Therapy (NRT) Sampling
    Chicago, United StatesAge 18+

Support organisations

Patient organisations and helplines in United States, for you and your family.

We have no organisations for this disease listed in United States yet. General support there is below.

General support in United States

  • 988 Suicide & Crisis Lifeline

    US national 24/7 free and confidential lifeline for anyone in suicidal crisis or emotional distress, reachable by calling or texting 988 or by chat.

    988lifeline.org
  • MedlinePlus

    Free, easy-to-read health information service of the US National Library of Medicine (NIH) on diseases, conditions, drugs and wellness.

    medlineplus.gov

International organisations

Patient organisation umbrella bodies

Offer tissue or data

There are three ways to help research move faster.

Give tissue or bloodA biobank stores your sample so many research teams can use it.No open programme yet
Share your health dataA patient registry collects your health data, without your name, for research.How to join
Take part as a healthy volunteerStudies also need people without the disease, for comparison. Family and friends can help.Volunteer

“Miracle cure” fact checker

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Before you pay for anything, ask three things

  1. Is there a published study in people?
  2. Can I have the full price in writing?
  3. What does my doctor say?

“Cures” others already fact-checked

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