Tests propranolol for language problems in primary progressive aphasia
Tests whether propranolol affects language in older adults with primary progressive aphasia.
Plain-language title generated from the registry record
Registry title: Propranolol in Primary Progressive Aphasia
Key facts
- Where
- Columbia, United StatesSee the site
- Phase
- Early phase 1
Where in United States
- University of Missouri - ColumbiaColumbia, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Missouri-Columbia
- Trial code
- NCT06066710
- Record updated
- 17 July 2026
- Original description
The purpose of this study is to find out how the language of people with Primary Progressive Aphasia is affected by Propranolol. Propranolol is not FDA approved for the treatment of Primary Progressive Aphasia. Propranolol is FDA approved for the treatment of heart conditions such as blood pressure.Read full original descriptionShow less
Trial of Propranolol in Older Adults With Primary Progressive Aphasia
The purpose of this study is to find out how the language of people with Primary Progressive Aphasia is affected by Propranolol. Propranolol is not FDA approved for the treatment of Primary Progressive Aphasia. Propranolol is FDA approved for the treatment of heart conditions such as blood pressure.
This research is being done because there are currently no drug treatment options for language impairments and anxiety often experienced by people with Primary Progressive Aphasia.
Inclusion: 1. Age: 50 and older; 2. Primary Progressive Aphasia diagnosis; 3. Native English speaker.
Exclusion: 13. Drugs that interact with propranolol, such as alpha 2 agonists; 14. Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to MR scanning. Subjects with any implanted device that cannot be verified as MRI compliant will be excluded; 4. Major head trauma that contributed to their condition; 5. Allergic reaction to adhesives; 7. Diabetes; 8. Reactive airway disease; 1. Unable to provide consent; 2. Taking alpha 2 agonists (clonidine and guanfacine); 3. Other major psychological or neurological diagnosis; 6. Uncorrected vision/hearing impairments; 9. Untreated hypothyroidism; 10. Bradyarrhythmia; 11. Unexplained syncope; 12. Pregnancy (assessed verbally on the days of MR imaging).