Frontotemporal dementia trials in United States

In United States 53 Also abroad 110

53 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Evaluation of Biochemical Markers and Clinical Investigation of Niemann-Pick Disease, Type C
Where
Bethesda
Age
1 day to 120 years
People
900
Run by
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
See details and how to joinNCT00344331
No phaseTaking people
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Where
Bethesda
Age
18 years to 110 years
People
360
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT03225144
Phase 1Taking people
A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
Where
Charlestown, Decatur, Durham, Maitland, The Villages, Toms River
Age
50 years to 85 years
People
56 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06297590 · EU 2024-510604-37-00
No phaseTaking people
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
Where
Sioux Falls
People
20,000
Run by
Sanford Health
See details and how to joinNCT01793168
No phaseNot yet taking people in United States
Personalized Closed-Loop Brain Stimulation for Patients With Primary Progressive Aphasia
Where
Baltimore
Age
45 years to 85 years
People
10
Run by
Johns Hopkins University
See details and how to joinNCT07511179
No phaseTaking people
Establishment of Genomic and Phenotypic Database for Niemann-Pick Disease, Type C
Where
Bethesda
Age
3 months and over
People
100
Run by
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
See details and how to joinNCT05588167
No phaseNot yet taking people in United States
A Wearable Sensor Platform for Remote Monitoring of Individuals on the Frontotemporal Dementia Spectrum
Where
Boston, Lutherville
Age
40 years and over
People
60
Run by
BioSensics
See details and how to joinNCT07569367
No phaseTaking people
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
Where
Ann Arbor, Atlanta, Baltimore, Bethesda, Birmingham, Boston, Chapel Hill, Chicago, Cleveland, Denver, Houston, Indianapolis, Jacksonville, Los Angeles, Nashville, New York, Philadelphia, Rochester, San Antonio, San Diego, San Francisco, Seattle, St Louis
Age
18 years and over
People
2,100 worldwide
Run by
Mayo Clinic
See details and how to joinNCT04363684
No phaseEnrolling by invitation
Alzheimer's Disease Neuroimaging Initiative 4
Where
Albany, Ann Arbor, Atlanta, Baltimore, Birmingham, Boston, Buffalo, Charleston, Chicago, Cleveland, Columbus, Dallas, Durham, Fairway, Gainesville, Houston, Indianapolis, Iowa City, Irvine, Jacksonville, La Jolla, Las Vegas, Lexington, Los Angeles, Madison, Miami, Miami Beach, Nashville, New Haven, New York, Orangeburg, Orlando, Palo Alto, Philadelphia, Phoenix, Pittsburgh, Portland, Providence, Rochester, San Antonio, San Francisco, St Louis, Sun City, Tampa, Tulsa, Walnut Creek, Washington D.C., Winston-Salem
Age
55 years to 90 years
People
1,500 worldwide
Run by
University of Southern California
See details and how to joinNCT05617014
Phase 3Taking people
PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using [18F]-PI-2620
Where
Philadelphia
Age
18 years and over
People
72
Run by
University of Pennsylvania
See details and how to joinNCT05456503
No phaseTaking people
Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA
Where
Baltimore
Age
50 years to 80 years
People
60
Run by
Johns Hopkins University
See details and how to joinNCT03887481
No phaseTaking people
Remotely-supervised Neuromodulation in PPA
Where
Austin, San Francisco
Age
40 years and over
People
80
Run by
Maya Henry
See details and how to joinNCT07260253
Phase 1Taking people
UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells
Where
Durham
Age
1 week to 22 years
People
40
Run by
Joanne Kurtzberg, MD
See details and how to joinNCT02254863
No phaseTaking people
Biofluid Research on Age-Related or Inherited Neurodegeneration
Where
Philadelphia
Age
18 years and over
People
1,000
Run by
University of Pennsylvania
See details and how to joinNCT07798700
No phaseTaking people
Using the EHR to Advance Genomic Medicine Across a Diverse Health System
Where
Philadelphia
Age
18 years and over
People
1,000
Run by
University of Pennsylvania
See details and how to joinNCT06377033
Phase 1/2Taking people
A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)
Where
Columbus, Houston, Nashville
Age
30 years to 75 years
People
18 worldwide
Run by
AviadoBio Ltd
See details and how to joinNCT06064890 · EU 2023-509444-10-00
No phaseEnrolling by invitation
ScreenPlus: A Comprehensive, Flexible, Multi-disorder Newborn Screening Program
Where
Brooklyn, Manhasset, New York, Queens, The Bronx
Age
Up to 4 weeks
People
100,000
Run by
Albert Einstein College of Medicine
See details and how to joinNCT05368038
Early phase 1Taking people
Propranolol in Primary Progressive Aphasia
Where
Columbia
Age
50 years and over
People
30
Run by
University of Missouri-Columbia
See details and how to joinNCT06066710
Phase 2Taking people
Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease
Where
New York
Age
50 years and over
People
100
Run by
Columbia University
See details and how to joinNCT04576793
No phaseTaking people
Neurologic Stem Cell Treatment Study
Where
Coral Springs, Westport
Age
18 years and over
People
500 worldwide
Run by
MD Stem Cells
See details and how to joinNCT02795052
No phaseEnrolling by invitation
Learning Amyloid and Tau Results
Where
Madison
Age
45 years to 89 years
People
240
Run by
University of Wisconsin, Madison
See details and how to joinNCT07222930
Phase 4Enrolling by invitation
Imaging of Brain Amyloid Plaques in the Aging Population
Where
Rochester
Age
30 years to 100 years
People
8,000
Run by
Mayo Clinic
See details and how to joinNCT00950430
No phaseTaking people
Stimulating the Aging Brain Using Brain and Sensory Stimulation
Where
Milwaukee
Age
45 years and over
People
20
Run by
Medical College of Wisconsin
See details and how to joinNCT07650188
No phaseTaking people
Clinical Procedures to Support Research in ALS
Where
Durham, Irvine, Kansas City, Miami, Minneapolis, New York, Palo Alto, Portland, San Antonio, San Francisco, Winston-Salem
Age
18 years and over
People
1,200
Run by
University of Miami
See details and how to joinNCT03489278
No phaseTaking people
Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
Where
Austin
Age
40 years and over
People
60 worldwide
Run by
Stephanie Grasso
See details and how to joinNCT05741853