Tests two speech-language therapies for primary progressive aphasia
Compares two speech therapies in adults with mild-moderate primary progressive aphasia.
Plain-language title generated from the registry record
Registry title: Communication Bridge 3 Study
Key facts
- Where
- Chicago, United StatesSee the site
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 100 years old?
Source: NCT06191198, who can take part
Where in United States
- University of Chicago - American School BuildingChicago, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Chicago
- Trial code
- NCT06191198
- Record updated
- 1 June 2026
- Original description
This study will use a randomized controlled trial design to evaluate the effect of two evidence-based treatments for adults with mild-moderate Primary Progressive Aphasia (PPA). The aim of the study is to help us better understand the effects of speech-language therapy on communication abilities in individuals with PPA.Read full original descriptionShow less
Communication Bridge: Optimizing an Evidence-based Intervention for Individuals With Primary Progressive Aphasia
This study will use a randomized controlled trial design to evaluate the effect of two evidence-based treatments for adults with mild-moderate Primary Progressive Aphasia (PPA). The aim of the study is to help us better understand the effects of speech-language therapy on communication abilities in individuals with PPA.
Inclusion: Meets diagnostic criteria for PPA based on neurologist and supporting medical assessments (extracted from medical records); English as primary language used in daily communication activities (by self-report); Adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report); Adequate vision (aided or unaided) for reading a newspaper, or other functional materials (by self-report); Able to pass technology screening and demonstrates sufficient knowledge for use of video conference and Communication Bridge™ web application use (with or without training); Geriatric Depression Scale score ≤ 9; Mild-moderate PPA informed by a structured interview with a speech-language pathologist and a standardized testing battery; 18+ years of age; English as primary language used in daily communication activities (by self-report); Adequate hearing (aided or unaided) for communicating with others in a crowded room (by self-report); Able to pass technology screening* and demonstrates sufficient knowledge for use of video conference and Communication Bridge™ web application use (with or without training).
Exclusion: Participation is co-enrolled in an outside speech language therapy program during the study course; A dementia diagnosis other than Primary Progressive Aphasia; Communication partners will be excluded if they have a pre-existing communication impairment that would affect study participation (e.g., aphasia, dementia); Medical records will be requested and reviewed to determine eligibility.