Low-Intensity Focused Ultrasound and the Complex Patient

Who can take part

• Males and females aged 18-65 years
• Current diagnosis of Chronic Back Pain as defined by pain duration of at least three months, with back pain being an ongoing problem for at least half the days of the last six months
• Have evidence of central sensitization (CS) as measured by the Widespread Pain/Symptom Severity Index (WPSSI) with a score of Widespread Pain Index (WPI) ≥ 7 and Symptom Severity (SS) ≥ 5 or WPI = 3-6 and SS ≥ 9
• Meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for current opiate use disorder as diagnosed by the Structured Clinical Interview for DSM-5
• Be in treatment for opioid use disorder (OUD) including buprenorphine or methadone
• Meet the DSM-5 criteria for a current anxiety disorder: generalized anxiety disorder, post-traumatic stress disorder or social anxiety disorder as diagnosed by the Structured Clinical Interview for DSM-5

Who cannot take part

• Previous spine surgery
• Ferromagnetic implants or other contraindications for magnetic resonance imaging (MRI)
• Current substance use disorder other than OUD or tobacco use disorder
• Current DSM-5 diagnosis of schizophrenia or schizo-affective disorder
• Chronic Pain Conditions other than chronic back pain
• History of head injury, seizures, neurologic disorders including cerebrovascular disease, stroke, brain surgery, brain tumor, multiple sclerosis, or neurodegenerative diseases
• History of metastasizing cancers, inflammatory disorder (rheumatoid arthritis, polymyalgia rheumatica, scleroderma, lupus or polymyositis), unintended weight loss of 20 pounds or more in the last year, or cauda equina syndrome
• Unstable medical conditions such as congestive heart failure, unstable angina, poorly controlled arrhythmia active system infection end stage renal disease
• Evidence of arteriovenous malformation, aneurysm, infarct, meningioma, parenchymal brain tumor or evidence of neurodegenerative processes and/or white matter lesions greater than that expected for age as determined by the study neuroradiologist
• Evidence of neuropathic pain
• Daily opiate use other than buprenorphine/methadone for OUD/pain control
• Pregnant or breastfeeding