Opioid use disorder trials in United States

In United States 229 Also abroad 250

229 trials · From ClinicalTrials.gov, checked 15 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Teaching Health Resilience in a Hospital Setting: A Peer-led Intervention
Where
Pittsburgh
Age
18 years and over
People
300
Run by
University of Pennsylvania
See details and how to joinNCT06843213
No phaseNot yet taking people in United States
Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine
Where
Bedford, Boston, Portland, West Haven
Age
18 years and over
People
250
Run by
VA Office of Research and Development
See details and how to joinNCT07361432
No phaseNot yet taking people in United States
Improving Access to Opioid Use Disorder Treatment Among Marginalized Patients With a Tailored Telehealth Intervention
Where
Philadelphia
Age
18 years and over
People
60
Run by
University of Pennsylvania
See details and how to joinNCT06341608
No phaseTaking people
Continuum of Care in Hospitalized Patients With Opioid/Stimulant Use Disorder and Infectious Complications From Drug Use
Where
Atlanta, Baltimore, Morgantown, Washington D.C.
Age
18 years and over
People
304
Run by
Elana Rosenthal
See details and how to joinNCT06513156
No phaseNot yet taking people in United States
Development of an Opioid Withdrawal Clinical Outcome Assessment
Where
Baltimore
Age
18 years and over
People
30
Run by
University of Maryland, Baltimore
See details and how to joinNCT07094672
Phase 1Not yet taking people in United States
Phase 1 Study of Oral MG001
Where
Overland Park
Age
18 years to 65 years
People
32
Run by
National Institute on Drug Abuse (NIDA)
See details and how to joinNCT07204171
Phase 4Not yet taking people in United States
Comparing Outpatient Treatment Retention Among Individuals Using Fentanyl Randomized to Low-dose and Direct-to-inject Buprenorphine Initiation
Where
San Francisco
Age
18 years and over
People
50
Run by
University of California, San Francisco
See details and how to joinNCT07469501
Phase 2Taking people
E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder
Where
New York, The Bronx
Age
21 years to 75 years
People
302
Run by
NYU Langone Health
See details and how to joinNCT05722561
No phaseTaking people
Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial
Where
Arcata, Minneapolis, Toppenish
Age
18 years and over
People
225
Run by
University of New Mexico
See details and how to joinNCT06565416
Phase 4Not yet taking people in United States
NOTRE: Optimizing Long-Acting Pre-Exposure Prophylaxis and Medications for Opioid Use Disorder Interventions in Carceral Settings
Where
Durham
Age
18 years and over
People
450
Run by
Duke University
See details and how to joinNCT06854029
No phaseNot yet taking people in United States
Prescribe to Prevent HIV: A Hybrid Trial Helping Addiction Clinics Prevent HIV & Infections Through Safer Drug Use Support
Where
Pittsburgh
Age
18 years and over
People
536
Run by
University of Pittsburgh
See details and how to joinNCT07073924
Early phase 1Taking people
Evaluating Pain Control Strategies in Postpartum Patients on Opioid Use Disorder Medications.
Where
Milwaukee
Age
18 years to 40 years
People
20
Run by
Medical College of Wisconsin
See details and how to joinNCT06617949
Phase 2Taking people
Targeting Treatment-Resistant OUD With Ketamine-Assisted Mindfulness Oriented Recovery Enhancement
Where
La Jolla, Salt Lake City
Age
18 years and over
People
88
Run by
University of California, San Diego
See details and how to joinNCT07369089
No phaseNot yet taking people in United States
Disease Intervention Specialist (DIS) for SUD
Where
Columbus
Age
18 years and over
People
1,200
Run by
Ohio State University
See details and how to joinNCT07875361
Phase 2Taking people
A Study of Brenipatide in Participants With Opioid Use Disorder
Where
Baltimore, Boston, Bradenton, Charleston, Charlottesville, Chicago, Columbus, Daytona Beach, DeSoto, Fountain Valley, Hollywood, Houston, Indianapolis, Lakeland, Lexington, Little Rock, Miami, Monroe, Naples, New York, Oklahoma City, Philadelphia, Phoenix, Port Charlotte, Providence, Ridgeland, Roanoke, Rockville, Rose Hill, San Francisco, Seattle, Sioux Falls, Snellville, Springfield, Tampa, The Bronx, Watertown, West Palm Beach
Age
18 years to 75 years
People
465 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07420283
No phaseTaking people
Using Facebook to Support Opioid Recovery Among American Indian Women
Where
Rochester
Age
18 years and over
People
60
Run by
Mayo Clinic
See details and how to joinNCT05995886
Phase 2Taking people
Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage
Where
Galveston
Age
18 years to 100 years
People
15
Run by
The University of Texas Medical Branch, Galveston
See details and how to joinNCT07294118
No phaseNot yet taking people in United States
Remote Intervention to Prevent Overdose
Where
Birmingham
Age
18 years and over
People
100
Run by
University of Alabama at Birmingham
See details and how to joinNCT07128485
No phaseNot yet taking people in United States
Peer-led, Mobile App Supported Linkage to Opioid Use Disorder Treatment
Where
Baltimore
Age
18 years to 99 years
People
90
Run by
Johns Hopkins University
See details and how to joinNCT07900828
Phase 4Not yet taking people in United States
Examining Analgesic Synergy and Efficacy in Trauma Care
Where
Winston-Salem
Age
18 years to 80 years
People
282
Run by
Wake Forest University Health Sciences
See details and how to joinNCT07435077
No phaseNot yet taking people in United States
Real World Evaluation of the Effectiveness and Implementation of a Digital Health Therapeutic for OUD
Where
San Antonio
Age
18 years and over
People
134
Run by
The University of Texas Health Science Center at San Antonio
See details and how to joinNCT07348796
No phaseEnrolling by invitation
PATH to Reducing Burnout Among Peers Who Deliver Overdose Prevention Services (R33 Phase Clinical Trial)
Where
Chicago
Age
18 years and over
People
200
Run by
Chestnut Health Systems
See details and how to joinNCT07886944
No phaseTaking people
Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder
Where
Baltimore
Age
21 years to 60 years
People
150
Run by
National Institute on Drug Abuse (NIDA)
See details and how to joinNCT03745339
Early phase 1Not yet taking people in United States
Pain Sensitivity, Alcohol-Induced Analgesia, and Heavy Drinking in Individuals With Opioid Use Disorder
Where
Columbus
Age
21 years to 65 years
People
90
Run by
Ohio State University
See details and how to joinNCT07894276
Phase 2Taking people
A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic Pain
Where
Houston, North Canton
Age
18 years to 65 years
People
45
Run by
Adneuris Therapeutics, Inc.
See details and how to joinNCT07874620