NeuroControl of Nicotine Dependence
Key facts
- Who runs it
- University of Missouri-Columbia
- Where
- Columbia, United StatesSee the site
- Trial code
- Status
- Withdrawn
- Started
- 1 Oct 2024
- Expected to end
- 30 Apr 2030
- Type of study
- Interventional, 3 groups
- Treatments tested
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Record updated
- 9 October 2026
- Why it stopped
- Funding
Who can take part
- Age
- 18 years to 60 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- Nicotine Dependence as measured by: Smoke ≥ 8 cigarettes/day for ≥ 2 yrs, expired carbon monoxide (CO) concentration of ≥ 10 ppm, positive urine cotinine test and FTND score ≥ 3 Or ≥ 15 uses of electronic cigarette/day for ≥ 1 year, positive urine cotinine test, and PS-ECDI score ≥ 3
- English Fluency
- Functional Vision (with corrective lenses as needed)
Who cannot take part
- Use of psychotropic and antiepileptic medications in the last month
- Electroconvulsive therapy in the past 6 months
- Presence of an untreated illness or serious medical condition
- History of major neurological illness
- Contraindication to TMS (history of neurological disorder or seizure, increased intracranial pressure, brain surgery, or head trauma with loss of consciousness for >15 min., implanted electronic device, metal in the head) or MRI
- Any use of substances that lower seizure threshold
- Unstable cardiac disease or hypertension, severe renal or liver insufficiency, or sleep apnea
- Current or past psychosis
- BAC greater than 0.0
- Positive urine pregnancy test
- Any other concern that in the investigator's opinion would impact participant safety, study instruction compliance, or confound the interpretation of the study results
Where in United States
- Health Neuroscience CenterColumbia, United States
About the trial
What the trial wants to find out
The purpose of the study is to examine the effects of continuous theta burst stimulation (cTBS) on different forms of cognitive control in adults who smoke cigarettes, and to determine if the location where cTBS is delivered may help smokers reduce or quit smoking. Participation in the study will take 3-weeks over 4 visits, with a total time commitment of approximately 12 hours.
The 3 groups in the trial
- cTBS to Ventrolateral Prefrontal CortexTreatment being tested
Continuous theta-burst stimulation (cTBS), a form of repetitive transcranial magnetic stimulation (rTMS), affects brain areas stimulated directly underneath the scalp and brain areas that are functionally connected. cTBS will be applied to the ventrolateral prefrontal cortex.
Treatment: Repetitive Transcranial Magnetic Stimulation (rTMS)
- cTBS to Dorsomedial Prefrontal CortexTreatment being tested
Continuous theta-burst stimulation (cTBS), a form of repetitive transcranial magnetic stimulation (rTMS), affects brain areas stimulated directly underneath the scalp and brain areas that are functionally connected. cTBS will be applied to the dorsomedial prefrontal cortex.
Treatment: Repetitive Transcranial Magnetic Stimulation (rTMS)
- cTBS to VertexTreatment being tested
Continuous theta-burst stimulation (cTBS), a form of repetitive transcranial magnetic stimulation (rTMS), affects brain areas stimulated directly underneath the scalp and brain areas that are functionally connected. cTBS will be applied to the vertex.
Treatment: Repetitive Transcranial Magnetic Stimulation (rTMS)
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Neuronavigated Non-invasive Brain Stimulation for Nicotine Dependence.
- Record updated
- 9 October 2026