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A Smartphone Application (QuitBot) for the Improvement of Smoking Cessation Among American Indians and Alaska Natives, NAITIVE Trial

Key facts

Who runs it
Fred Hutchinson Cancer Center
Where
Seattle, United StatesSee the site
Trial code
Status
Not yet recruiting
People taking part
772 people, planned
Starts
30 Nov 2026
Expected to end
31 Oct 2030
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • QuitBot Smoking Cessation Chatbot Program
  • QuitBot Smoking Cessation Text Messaging Program
  • Survey Administration
  • Interview
  • Carbon Monoxide Measurement
Record updated
20 October 2026

Who can take part

Age
18 years and older
Sex
Women and men
Healthy volunteers
Can take part

The registry criteria, word for word

Show all 19 criteriaShow less

Who can take part

  • Self-identifying as American Indian or Alaska Native, either alone or in combination with other races
  • Age 18 and older
  • Smoking combustible cigarettes daily in the past year
  • Interest in quitting smoking
  • Interest in learning skills to quit smoking
  • Willing to be randomly assigned
  • Have daily access to their own Android or iPhone smartphone
  • Ability to download a smartphone app
  • Ability to read English
  • Not currently (i.e., within past 30 days) using other smoking cessation interventions
  • No prior participation in our studies
  • No prior use of SFT
  • No household or family member participating
  • US residency for the next twelve months
  • Willingness to complete follow-up assessments at the 3-, 6-, and 12-month follow-ups
  • Providing email, phone number(s), and mailing address

Who cannot take part

  • The reverse of the inclusion criteria
  • Pregnant or breastfeeding
  • Use of other tobacco products (e.g., ceremonial use of tobacco, e-cigarettes) will be assessed but is not an exclusion criterion, as it would limit the study's generalizability

Where in United States

  • Fred Hutch/University of Washington Cancer ConsortiumSeattle, United StatesContact: Jonathan Bricker, PhDNot yet recruiting

About the trial

What the trial wants to find out

This clinical trial develops a chatbot smartphone application (app), QuitBot, and text messaging to help American Indians (AI) and Alaska Natives (AN) to quit smoking commercial tobacco (smoking cessation), and evaluates two remote smoking cessation programs to see how well they work for helping AI/AN people quit smoking commercial tobacco. AI/AN populations have one of the highest rates of commercial cigarette smoking of any racial and ethnic group in the United States (US). They also have a higher rate of developing smoking-related cancer but are less likely to quit smoking. The two programs are designed to provide personalized support in setting a smoking cessation goal, tasks to reach the smoking cessation goal, and motivation to remain smoke-free. This may help to keep participants engaged and support them in their quit efforts, and may improve smoking cessation among AI and AN.

The 2 groups in the trial

  • Arm I (QuitBot chatbot)Treatment being tested

    Participants participate in the QuitBot program which involves chatbot messages over 42 days. Therapy description withheld to protect the integrity of the study.

    Treatment: QuitBot Smoking Cessation Chatbot Program, Survey Administration, Interview, and Carbon Monoxide Measurement

  • Arm II (QuitBot texting)Existing treatment, for comparison

    Participants participate in the QuitBot program which involves text messages over 42 days. Therapy description withheld to protect the integrity of the study.

    Treatment: QuitBot Smoking Cessation Text Messaging Program, Survey Administration, and Carbon Monoxide Measurement

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Navigation and Artificial Intelligence Technology for Indigenous Virtual Education on Smoking Cessation (NAITIVE)
Record updated
20 October 2026