Taking people in United StatesPhase 3

Tests duvakitug in adults with active Crohn's disease

Tests duvakitug against placebo in people with moderately to severely active Crohn's disease.

Plain-language title generated from the registry record
Registry title: An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

Key facts

Where: Atlanta, Aurora, Baltimore, Baton Rouge, Baytown, Bellevue, Boston, Canoga Park, Canton, Chapel Hill, Charlotte, Chicago, Clermont, Cleveland, Clive, Colorado Springs, Columbia, Columbus, Cordova, Coronado, Dallas, Dayton, Denver, Des Plaines, Durham, East Orange, Escondido, Fargo, Fayetteville, Folsom, Freehold, Gainesville, Glenview, Gurnee, Harlingen, Hershey, Houma, Idaho Falls, Jackson, Kansas City, Kingsport, Kingwood, Kissimmee, Lake Jackson, Lancaster, Las Vegas, Laurel, Lexington, Liberty, Little Rock, Los Angeles, Lubbock, Lynchburg, Mandeville, Marrero, Maspeth, Mesquite, Metairie, Miami, Milwaukee, Monroe, Morristown, Murrieta, New Albany, New Haven, New Iberia, New York, Norman, Novi, Orlando, Oxnard, Palmetto Bay, Peoria, Philadelphia, Pittsburgh, Portland, Providence, Raleigh, Rancho Cucamonga, Richmond, Sacramento, San Antonio, San Diego, Sandy Springs, Scottsdale, Snellville, Somers Point, Southlake, Sparta, Springboro, St Louis, Sunrise, Suwanee, Tampa, Tarzana, The Bronx, Thousand Oaks, Toledo, Tomball, Tucson, Tyler, Valencia, Vancouver, Victorville, Waterloo, West Jordan, Westlake, Worcester, and Wyoming, United StatesSee the 127 sites
Phase: Phase 3

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 16 and 80 years old?

Source: NCT07184931, who can take part

Where in United States

Atlanta Gastroenterology Associates-Site Number: 8400109Atlanta, United StatesTaking people
UCHealth Digestive Health Center - Anschutz Medical Campus-Site Number: 8400085Aurora, United StatesTaking people
Mercy Medical Center, Baltimore-Site Number: 8400117Baltimore, United StatesTaking people
GI Alliance - Baton Rouge-Site Number: 8400129Baton Rouge, United StatesTaking people
Inquest Clinical Research-Site Number: 8400144Baytown, United StatesTaking people
GI Alliance - Bellevue-Site Number: 8400143Bellevue, United StatesTaking people
Tufts Medical Center-Site Number: 8400126Boston, United StatesTaking people
Alliance Research Institute-Site Number: 8400008Canoga Park, United StatesTaking people
Gastroenterology & Hepatology Specialists, Inc.-Site nUmber: 8400139Canton, United StatesTaking people
UNC Hospitals, The University of North Carolina at Chapel Hill-Site Number: 8400074Chapel Hill, United StatesTaking people
OnSite Clinical Solutions-Site Number: 8400051Charlotte, United StatesTaking people
Rush University Medical Center-Site Number: 8400015Chicago, United StatesTaking people
Novum Research, LLC-Site Number: 8400003Clermont, United StatesTaking people
University Hospitals Cleveland Medical Center-Site Number: 8400073Cleveland, United StatesTaking people
Heartland Medical Research, Inc.-Site Number: 8400134Clive, United StatesTaking people
Peak Gastroenterology Associates - Colorado Springs-Site Number: 8400039Colorado Springs, United StatesTaking people
Biocentric Health Research Center-Site Number: 8400089Columbia, United StatesTaking people
Johns Hopkins University Gastroenterology and Hepatology-Site Number: 8400116Columbia, United StatesTaking people
Ohio Gastroenterology Group Inc.-8400006Columbus, United StatesTaking people
OSU Wexner Medical Center-Site Number: 8400077Columbus, United StatesTaking people
Gastro One - Cordova-Site Number: 8400158Cordova, United StatesTaking people
Southern California GI & Liver Centers-Site Number: 8400062Coronado, United StatesTaking people
The University of Texas Southwestern Medical Center-Site Number: 8400098Dallas, United StatesTaking people
DSI Research Northridge - Dayton-Site Number: 8400115Dayton, United StatesTaking people
Gastroenterology of the Rockies - Denver-Site Number: 8400122Denver, United StatesTaking people
Midwest Digestive Health and Nutrition-Site Number: 8400136Des Plaines, United StatesTaking people
Duke University Medical Center-Site Number: 8400093Durham, United StatesTaking people
Sanmora Bespoke Clinical Research Solutions LLC-Site Number: 8400123East Orange, United StatesTaking people
Gastroenterology and Liver Institute - Escondido-Site Number: 8400146Escondido, United StatesTaking people
Plains Clinical Research Center-Site Number: 8400078Fargo, United StatesTaking people
Cross Creek Medical Clinic-Site Number: 8400057Fayetteville, United StatesTaking people
GMC Clinical Research, LLC-Site Number: 8400113Folsom, United StatesTaking people
Allied Health Clinical Research Organization, LLC - Freehold-Site Number: 8400014Freehold, United StatesTaking people
Sarkis Clinical Trials - Gainesville-Site Number: 8400048Gainesville, United StatesTaking people
GI Alliance - Glenview-Site Number: 8400068Glenview, United StatesTaking people
GI Alliance - Gurnee-Site Number: 8400049Gurnee, United StatesTaking people
Valley Institute of Research-Site Number: 8400004Harlingen, United StatesTaking people
Penn State Milton S. Hershey Medical Center-Site Number: 8400066Hershey, United StatesTaking people
Tandem Intermediate, LLC - Houma-Site Number: 8400034Houma, United StatesTaking people
Grand Teton Research Group, PLLC-Site Number: 8400127Idaho Falls, United StatesTaking people
Allied Health Clinical Research Organization, LLC - Jackson-Site Number:8400007Jackson, United StatesTaking people
University of Kansas Medical Center-Site Number: 8400110Kansas City, United StatesTaking people
Tri-Cities Gastroenterology-Site Number: 8400076Kingsport, United StatesTaking people
One of a Kind Clinical Research Center TX, LLC-Site Number; 8400125Kingwood, United StatesTaking people
Clinical Research of Osceola-Site Number: 8400013Kissimmee, United StatesTaking people
Innovare Research Group-Site number: 8400067Lake Jackson, United StatesTaking people
Om Research, LLC - Lancaster-Site Number: 8400148Lancaster, United StatesTaking people
Las Vegas Clinical Trials-Site Number: 8400079Las Vegas, United StatesTaking people
Mid-Atlantic GI Research, LLC-Site Number: 8400106Laurel, United StatesTaking people
University of Kentucky Hospital/UK Albert B. Chandler Hospital-Site Number: 8400058Lexington, United StatesTaking people
BVL Clinical Research-Site Number: 8400005Liberty, United StatesTaking people
Preferred Research Partners-Site Number: 8400018Little Rock, United StatesTaking people
GastroIntestinal Bioscience - Los Angeles-Site Number: 8400019Los Angeles, United StatesTaking people
TLC Clinical Research Inc.-Site Number: 8400030Los Angeles, United StatesTaking people
GI Alliance - Lubbock-Site Number: 8400092Lubbock, United StatesTaking people
Blue Ridge Medical Research-Site Number: 8400020Lynchburg, United StatesTaking people
Texas Digestive Disease Consultants, PLLC d/b/a GI Alliance - Mandeville-Site Number: 8400128Mandeville, United StatesTaking people
Tandem Clinical Research - Marrero-Site Number: 8400002Marrero, United StatesTaking people
MedTraits NY-Site Number: 8400045Maspeth, United StatesTaking people
SMS Clinical Research-Site Number: 8400035Mesquite, United StatesTaking people
GI Alliance - Metairie-Site Number: 8400124Metairie, United StatesTaking people
Bioresearch Partner-Kendale Lakes-Site Number: 8400053Miami, United StatesTaking people
Columbus Clinical Services LLc-Site Number: 8400038Miami, United StatesTaking people
Correa Research Center-Site Number: 8400010Miami, United StatesTaking people
Medical Professional Clinical Research Center-Site Number: 8400119Miami, United StatesTaking people
Paradisus Med Research-Site Number: 8400036Miami, United StatesTaking people
Regis Clinical Research, LLC-Site Number: 8400041Miami, United StatesTaking people
Sylvester Comprehensive Cancer Center - A University of Miami Hospital and Clinics Facility - Miami-Site Number: 8400111Miami, United StatesTaking people
Froedtert Hospital and the Medical College of Wisconsin-Site Number: 8400081Milwaukee, United StatesTaking people
Delta Research Partners-Site Number: 8400087Monroe, United StatesTaking people
Monroe Biomedical Research-Site Number: 8400046Monroe, United StatesTaking people
Atlantic Health System, Morristown Medical Center-Site Number: 8400137Morristown, United StatesTaking people
United Medical Doctors CA-Site Number: 8400044Murrieta, United StatesTaking people
Gastroenterology Health Partners, PLLC - New Albany-Site Number: 8400100New Albany, United StatesTaking people
Yale University Digestive Disease-Site Number: 8400108New Haven, United StatesTaking people
Care Access - New Iberia-Site Number: 8400031New Iberia, United StatesTaking people
Columbia University Medical Center-Site Number: 8400138New York, United StatesTaking people
Manhattan Clinical Research, LLC-Site Number: 8400069New York, United StatesTaking people
New York Gastroenterology Associates-Site Number: 8400009New York, United StatesTaking people
NYU Langone Health-Site Number: 8400091New York, United StatesTaking people
Weill Cornell Medicine - NewYork-Presbyterian Hospital-Site Number: 8400040New York, United StatesTaking people
Central Sooner Research-Site Number: 8400094Norman, United StatesTaking people
Henry Ford Medical Center - Columbus-Site Number: 8400118Novi, United StatesTaking people
AdventHealth Orlando-Site Number: 8400070Orlando, United StatesTaking people
Orlando Health, Inc.-Site Number: 8400084Orlando, United StatesTaking people
Om Research, LLC - Oxnard-Site Number: 8400150Oxnard, United StatesTaking people
Tropical Clinical Trials-Site Number: 8400082Palmetto Bay, United StatesTaking people
PeoriaPeoria, United StatesTaking people
University of Pennsylvania School of Medicine-Site Number: 8400072Philadelphia, United StatesTaking people
The Allegheny Health Network (AHN) Center for Digestive Health-Site Number: 8400107Pittsburgh, United StatesTaking people
Oregon Health & Science University-Site Number: 8400131Portland, United StatesTaking people
University Gastroenterology-Site Number: 8400103Providence, United StatesTaking people
ClinTrial Research, LLC-Site Number: 8400043Raleigh, United StatesTaking people
Prospective Research Innovations Inc.-Site Number: 8400017Rancho Cucamonga, United StatesTaking people
Clinical Research Partners-Site Number: 8400080Richmond, United StatesTaking people
UC Davis Health System-Site Number: 8400071Sacramento, United StatesTaking people
Gastroenterology Research of San Antonio LLC-Site Number: 8400054San Antonio, United StatesTaking people
Clinical Applications Laboratories Inc-Site Number: 8400056San Diego, United StatesTaking people
Medical Associates Research Group-Site Number:8400063San Diego, United StatesTaking people
M3 Wake Research - Atlanta-Site Number: 8400028Sandy Springs, United StatesTaking people
One of a Kind Clinical Research Center AZ, LLC-Site Number: 8400061Scottsdale, United StatesTaking people
Scottsdale Clinical Trials-Site Number: 8400145Scottsdale, United StatesTaking people
EBGS Clinical Research Center, LLC-Site Number: 8400037Snellville, United StatesTaking people
Tandem-Allied Clinical Research - Somers Point-Site Number: 8400050Somers Point, United StatesTaking people
Texas Digestive Disease Consultants, PLLC. dba GI Alliance - Southlake - Corporate Office-Site Number: 8400101Southlake, United StatesTaking people
Premier Health Research, LLC-Site Number: 8400114Sparta, United StatesTaking people
DSI Research - Springboro-Site Number: 8400105Springboro, United StatesTaking people
Gateway Gastroenterology-Site Number: 8400097St Louis, United StatesTaking people
Washington University School of Medicine-Site Number: 8400075St Louis, United StatesTaking people
Precision Clinical Research - Sunrise-Site Number: 8400059Sunrise, United StatesTaking people
Atlanta Gastroenterology Specialists-Site Number: 8400149Suwanee, United StatesTaking people
NMC Research LLC-Site Number: 8400033Tampa, United StatesTaking people
Valiance Clinical Research - Tarzana-Site Number: 8400023Tarzana, United StatesTaking people
Montefiore Medical Center - Bronx-Site Number: 8400142The Bronx, United StatesTaking people
Clinical Trials Management Services-Site Number: 8400047Thousand Oaks, United StatesTaking people
University of Toledo Medical Center-Site Number: 8400042Toledo, United StatesTaking people
Texas Gastro Consultants-Site Number: 8400029Tomball, United StatesTaking people
Del Sol Research Management, LLC-Site Number: 8400012Tucson, United StatesTaking people
Tyler Research Institute, LLC-Site Number: 8400095Tyler, United StatesTaking people
Amicis Research Center - Valencia-Site Number: 8400064Valencia, United StatesTaking people
The Vancouver Clinic Inc. P.S.-Site Number: 8400090Vancouver, United StatesTaking people
Om Research, LLC - Victorville-Site Number: 8400022Victorville, United StatesTaking people
Digestive Health Research Center-Site Number: 8400096Waterloo, United StatesTaking people
Velocity Clinical Research, Salt Lake City-Site Number: 8400147West Jordan, United StatesTaking people
North Shore Gastroenterology Research-Site Number: 8400130Westlake, United StatesTaking people
UMass Memorial Medical Center-Site Number: 8400121Worcester, United StatesTaking people
Gastroenterology Associates of Western Michigan-Site Number: 8400060Wyoming, United StatesTaking people

Questions to ask the study team

How often do I need to come in, and for how long each time?
Are travel costs paid?
Can I keep my own doctor?
What happens if I want to stop?

Print a page for my doctor

Trial details

Who runs it: Sanofi
Trial code: NCT07184931
Record updated: 21 October 2026
Original description: This is a multinational, multicenter, randomized, double-blind, placebo-controlled, Phase 3 induction study, comprised of 3 sub-studies, to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active CD. Study details include:Read full original descriptionShow less
A Multicenter, Multinational, Randomized, Double-blind, Placebo-controlled Phase 3, Induction Study to Evaluate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease
This is a multinational, multicenter, randomized, double-blind, placebo-controlled, Phase 3 induction study, comprised of 3 sub-studies, to evaluate the efficacy and safety of duvakitug in participants with moderately to severely active CD. Study details include:
The study duration may be up to 35 weeks with:
* Up to 5-week Screening Period. * 12-week Sub-Study 1 (Single Arm Open-Label Feeder Induction) or Sub-Study 2 (Pivotal Induction). * 12-week Sub-Study 3 (Extended Induction for non-responders). * 6 weeks (45 days) follow-up period for participants who do not enroll into the Pivotal Maintenance Study (EFC18327). The treatment duration will be up to 12 weeks in each sub-study.
The number of scheduled study visits for participants who continue to the Pivotal Maintenance Study (EFC18327) will be up to 8 (Sub-Study 1 and Sub-Study 2) and up to 15 for participants who enroll in Sub-Study 3.
Inclusion: Participants aged ≥18 and ≤80 years of age at Screening. Where permitted locally, participants 16 to <18 years of age who meet the definition of Tanner Stage 5 for development; Confirmed diagnosis of moderately to severely active Crohn's Disease (CD) for at least 3 months prior to baseline; Demonstrated inadequate response, have shown loss of response or intolerance to conventional therapies or advanced therapies (ATs).
Exclusion: Prior or current high-grade gastrointestinal (GI) dysplasia; Participants on treatment with but not on stable doses of conventional therapy prior to baseline; Participants receiving prohibited medications or therapies; Participants with previous exposure to anti-TL1A investigational therapy; The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trial; Participants with Ulcerative Colitis (UC) or indeterminate colitis; Participants with two entire missing segments of the: terminal ileum, right colon transverse colon, sigmoid and left colon, and rectum.
ClinicalTrials.gov NCT07184931