Crohn's disease trials in United States

In United States 125 Also abroad 422

125 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
Where
Anaheim, Ann Arbor, Atlanta, Aurora, Bellevue, Bethesda, Boston, Chapel Hill, Charlotte, Chicago, Clearwater, Clinton Township, Clive, Colorado Springs, Coronado, Dallas, Decatur, Denton, Dothan, Englewood, Evanston, Fort Myers, Great Neck, Gurnee, Hackensack, Hamden, Hershey, Houston, Indianapolis, Inverness, Kansas City, Lakewood, Lancaster, Liberty, Little Rock, Los Angeles, Louisville, Lubbock, Macon, Mansfield, Margate, Mentor, Miami, Middletown, Nashville, New Haven, New York, Oklahoma City, Orange, Orlando, Oxnard, Philadelphia, Phoenix, Port Jefferson, Providence, Richmond, Rochester, San Antonio, San Diego, Seattle, Sioux Falls, Southlake, St Louis, Sun City, Tacoma, Tampa, Topeka, Tucson, Tyler, Uniontown, University Park, Valencia, Washington D.C., Zachary
Age
16 years to 80 years
People
1,200 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06430801 · EU 2023-508636-61-00
Phase 3Taking people
Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)
Where
Bristol, Charlottesville, Garland, Liberty, Lubbock, New York, San Antonio, Southlake, Tacoma, Tyler, Ypsilanti
Age
18 years and over
People
1,380 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT06651281 · EU 2024-513533-20-00
No phaseTaking people
Longitudinal Immunophenotyping of Patients With Inflammatory Bowel Disease
Where
Bethesda
Age
18 years to 85 years
People
100
Run by
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
See details and how to joinNCT07619547
Phase 4Taking people
Iron Treatment for Iron Deficiency Anemia in Children and Young Adults With Crohn's Disease
Where
New York
Age
3 years to 21 years
People
150
Run by
Weill Medical College of Cornell University
See details and how to joinNCT07925450
Phase 2Not yet taking people in United States
Oral N-acetylglucosamine in Crohn's Disease
Where
Baltimore
Age
18 years to 80 years
People
40
Run by
Johns Hopkins University
See details and how to joinNCT07225998
Phase 3Taking people
A Study to Assess the Pharmacokinetics, Effectiveness and Safety of Afimkibart for Induction and Maintenance Therapy in Children With Moderately to Severely Active Crohn's Disease
Where
Harlingen, New York
Age
2 years to 17 years
People
100 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT07298421 · EU 2025-523318-96-00
Phase 2Taking people
A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease
Where
Atlanta, Bridgeton, Cedar Park, Colorado Springs, Denton, Fayetteville, High Point, Houma, Houston, Johnson City, Kissimmee, Lancaster, Lewisville, Lynchburg, Mansfield, Miami, North Las Vegas, Ogden, Orlando, Palmetto Bay, Raleigh, San Diego, Summerville, Tyler
Age
18 years to 85 years
People
385 worldwide
Run by
Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)
See details and how to joinNCT06226883 · EU 2023-508158-24-00
Phase 3Taking people
Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight
Where
Anaheim, Beverly Hills, Chevy Chase, Chicago, Cordova, Dothan, Fayetteville, Greenville, Idaho Falls, Indianapolis, Lebanon, Los Alamitos, Louisville, Miami, Milwaukee, New Albany, New Bedford, New Iberia, New York, Northridge, Orlando, Pensacola, Philadelphia, Providence, San Antonio, Shreveport, St Louis, Sunrise, Tacoma, Tyler, Westlake, Yonkers
Age
18 years to 70 years
People
290 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06937099 · EU 2024-520210-21-00
Phase 2Taking people
A Master Protocol (IIBD): A Study of Multiple Drugs in Adults With Ulcerative Colitis or Crohn's Disease
Where
Atlanta, Chicago, Englewood, Kingwood, Las Vegas, Los Angeles, Miami, Miami Lakes, Oxnard, San Antonio, Scottsdale, St Louis, Topeka, Wyoming
Age
18 years to 80 years
People
60 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07483073 · EU 2025-524112-11-00
Phase 2Taking people
A Study of LY4395089 and Mirikizumab (LY3074828) Given Together and Mirikizumab (Alone) in Adults With Crohn's Disease
Where
Atlanta, Chicago, Englewood, Kingwood, Las Vegas, Los Angeles, Miami, Miami Lakes, Oxnard, San Antonio, Scottsdale, St Louis, Topeka, Wyoming
Age
18 years to 80 years
People
60 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07483099
No phaseTaking people
A Study to Assess the Long-Term Safety of Ustekinumab Versus Other Biologics in Patients With Crohn's Disease and Ulcerative Colitis
Where
Houston
Age
18 years and over
People
1,536
Run by
Janssen Scientific Affairs, LLC
See details and how to joinNCT04372108
Phase 3Taking people
A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease
Where
Atlanta, Boston, Colchester, Dayton, Fort Worth, Hartford, Indianapolis, Los Angeles, Morristown, New York, Philadelphia
Age
2 years to 17 years
People
120 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT05923073 · EU 2023-504735-41-00
Phase 3Taking people
A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants
Where
Atlanta, Cincinnati, Fort Worth, Indianapolis, Salt Lake City
Age
3 years to 64 years
People
196 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06663332 · EU 2023-509560-16-00
Phase 2/3Taking people
A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease
Where
Anaheim, Atlanta, Austin, Canoga Park, Carmel, Carrollton, Chandler, Chapel Hill, Charleston, Charlotte, Chesapeake, Chevy Chase, Colorado Springs, Coronado, Crestview Hills, Cutler Bay, Dallas, Danbury, Glen Burnie, Harrisburg, Hershey, Houston, Indianapolis, Inverness, Jacksonville, Lafayette, Lakewood Rch, Lancaster, Litchfield Park, Los Angeles, Louisville, Lynchburg, Macon, Miami, Milwaukee, Newport Beach, New York, Oklahoma City, Oxnard, Philadelphia, Portland, Providence, Rochester, Rock Hill, San Antonio, San Diego, San Francisco, Scottsdale, Southlake, Tacoma, Tampa, Tyler, West Monroe, Wichita
Age
18 years and over
People
1,092 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07196722 · EU 2025-521382-27-00
No phaseEnrolling by invitation
Partial Enteral Nutrition as Therapeutic Augmentation of Advanced Pharmacological Therapy in Patients With Active Crohn's Disease
Where
Austin, Beverly Hills, Chapel Hill, New Brunswick, Philadelphia
Age
18 years to 80 years
People
80
Run by
James Lewis
See details and how to joinNCT07356232
Phase 3Taking people
A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease
Where
Anaheim, Atlanta, Carmel, Carrollton, Chapel Hill, Charlotte, Clive, Colorado Springs, Dothan, Farmington Hills, Glen Burnie, Hamden, Jacksonville, Lafayette, Lancaster, Los Alamitos, Los Angeles, Lubbock, Macon, Mentor, Miami, Mobile, Naples, New Bedford, New York, Northbrook, Oklahoma City, Orlando, San Antonio, San Diego, Shreveport, Summerville, Tampa, Topeka, Tyler, Uniontown
Age
18 years and over
People
530 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07499232
Phase 3Taking people
A Study of JNJ-78934804 in Participants With Moderately to Severely Active Crohn's Disease
Where
Anaheim, Chapel Hill, Chula Vista, Colorado Springs, Cordova, Crestview Hills, Farmington Hill, Lafayette, Lakewood Rch, Lee's Summit, Los Alamitos, Mentor, Metairie, Miami, New York, Oklahoma City, Orlando, Portland, Richmond, Rochester, San Diego, Scottsdale, Summerville, Sun City, Suwanee, Tacoma, Tampa, Tyler, Webster
Age
18 years and over
People
460 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07577843 · EU 2026-525922-39-00
Phase 4Taking people
A Remotely Conducted Study to Assess Concentration of TREMFYA in Breast Milk of Lactating Women Who Are Receiving TREMFYA Therapeutically
Where
Chapel Hill
Age
18 years and over
People
10
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07654751
Phase 2Taking people
A Study of SL-325 in Crohn's Disease Patients
Where
Boston, Cincinnati, Columbus, Glen Burnie, Houma, Inverness, Kansas City, Kissimmee, Liberty, Little Rock, Marrero, Maspeth, Naples, Nashville, Orlando, Oxnard, St Louis, Tampa, Temple City, West Hills
Age
18 years to 80 years
People
232
Run by
Shattuck Labs, Inc.
See details and how to joinNCT07753850
Phase 1/2Taking people
An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With Ustekinumab
Where
Bethesda
Age
18 years to 65 years
People
35
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
See details and how to joinNCT03167437
Phase 2Taking people
A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease
Where
Atlanta, Bellaire, Clearwater, Dallas, Decatur, Fort Worth, Glen Burnie, Greenville, Iowa City, Kansas City, Kingwood, Lakeland, Las Vegas, Liberty, Louisville, Mansfield, Mentor, Miami Lakes, Murrieta, Naples, New York, Oklahoma City, Orange, Orlando, Providence, Rochester, San Antonio, Seattle, Tampa, Tyler
Age
18 years to 75 years
People
268 worldwide
Run by
Takeda
See details and how to joinNCT06233461 · EU 2023-506704-14-00
Phase 2Taking people
A Study to Investigate Efficacy and Safety of Brivekimig in Participants With Crohn's Disease
Where
Boston, Chapel Hill, Colorado Springs, Escondido, Fairhope, Fredericksburg, Harrisburg, Houston, Iowa City, Kansas City, Kissimmee, Lancaster, Lighthouse PT, Marietta, Miami, Ogden, Orlando, Palmetto Bay, Richmond, San Diego, St Louis, Tucson, Wyoming
Age
18 years to 75 years
People
99 worldwide
Run by
Sanofi
See details and how to joinNCT06958536 · EU 2024-517016-30-00
No phaseTaking people
ALPCO Calprotectin CLIA Assay - Measurement of Calprotectin Levels in Human Stool
Where
Miami, Salem, Westlake
Age
22 years and over
People
1,000
Run by
American Laboratory Products Company
See details and how to joinNCT06810518
Phase 2Taking people
NOV-ERA - A Clinical Trial to Assess the Efficacy and Safety of Ontunisertib Compared to Placebo in Patients With Fibrostenosing Crohn's Disease
Where
Albany, Bradenton, Cedar Park, Fort Worth, Georgetown, Providence, Sun City
Age
18 years and over
People
320 worldwide
Run by
Agomab Spain S.L.U.
See details and how to joinNCT07683325
Phase 4Enrolling by invitation
INSIGHT-IBD Pragmatic Study
Where
Cedar Park, Fort Worth, Glenview, Gurnee, Houston, Indianapolis, Plano, Richmond, Rochester, San Antonio, San Marcos, Sun City, Tucson
Age
21 years and over
People
400
Run by
Specialty Networks Research.
See details and how to joinNCT07686757