Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment

Who can take part

• Age 65 and older with amnestic mild cognitive impairment (aMCI)
• Can speak English
• Agrees to MoBI recording
• Normal or corrected-to-normal vision/audition
• Able to walk unassisted for 10 minutes
• Plan to be in the area for next year

Who cannot take part

• Dementia (Memory Impairment/AD8 screening or a previous physician diagnosis of dementia)
• Hospitalization in the past six months or plans for surgery affecting participation in the next four months
• Medical conditions that affect participation such as vertigo and neck pain, history of falls, neuropathy, balance impairments, or vision or hearing deficits that are not adequately corrected
• Terminal illness with life expectancy less than 12 months or a serious chronic or acute illness that would prevent safe participation, such as late stage or metastatic cancer, active cancer treatment, chronic pulmonary disease requiring ventilator support or continuous oxygen therapy, or an active liver disease
• Progressive degenerative neurological disease, such as Parkinson disease or amyotrophic lateral sclerosis (ALS)
• Presence of clinical disorders that overtly alter attention like delirium
• Active psychosis or psychiatric symptoms such as agitation, that would prevent completion of the study procedures, a history of these symptoms alone will not be used as an exclusion criteria
• Standard contraindications to EEG including seizure medication, epilepsy, stroke, traumatic brain injury
• Pregnant women; Note: Adults ages 18 and older will also be enrolled for future age-based group comparisons
• Mobility limitations solely due to musculoskeletal limitation or pain
• Living in nursing home
• Participation in intervention trial