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Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine

Key facts

Who runs it
VA Office of Research and Development
Where
Bedford, Boston, Portland, and West Haven, United StatesSee the 4 sites
Trial code
Status
Not yet recruiting
People taking part
250 people, planned
Starts
4 Jan 2027
Expected to end
31 May 2030
Type of study
Interventional, 2 groupsOne group gets a placebo (a dummy treatment), for comparison.
Treatments tested
  • Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT)
  • Enhanced Treatment as Usual (ETAU)
Record updated
13 November 2026

Who can take part

Age
18 years and older
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 11 criteriaShow less

Who can take part

  • an ICD-11 opioid use disorder (OUD) diagnosis in the VHA electronic health record (EHR)
  • receipt of buprenorphine from outpatient addiction clinic with stable (i.e., unchanged in 2 weeks or since last injection) dose confirmed by the prescribing clinician. Both oral and injectable buprenorphine formulations will be eligible with dose stabilization required to isolate chronic pain from withdrawal-related pain associated with non-therapeutic dose
  • presence of musculoskeletal pain that is bothersome or high-impact per the Graded Pain Scale - Revised
  • access to a web-connected device to complete daily surveys and connect to Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT) treatment site
  • ability to participate safely in the walking portion of the intervention as evidenced by patient-reported ability to walk at least one block

Who cannot take part

  • planned surgical intervention for pain
  • dementia-related electronic health record (EHR) diagnosis
  • physical or mental health conditions that would interfere with ability to meaningful engage in Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT) and Medication for OUD (MOUD) treatment (e.g., uncontrolled bipolar disorder, active suicidal ideation, receipt of hospice or end-of-life palliative care)
  • participant-reported vision or hearing impairments that would preclude use of the Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT) system
  • legal actions that would make study completion unlikely
  • current or past 12 month engagement in CBT for chronic pain treatment

Where in United States

  • VA Bedford HealthCare System, Bedford, MABedford, United StatesContact: Erin Reilly, PhDNot yet recruiting
  • VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MABoston, United StatesContact: Rebekah Harris, DPTNot yet recruiting
  • VA Portland Health Care System, Portland, ORPortland, United StatesContact: Shannon Nugent, PhDNot yet recruiting
  • VA Connecticut Healthcare System West Haven Campus, West Haven, CTWest Haven, United StatesContact: R. Ross MacLean, PhDNot yet recruiting

About the trial

What the trial wants to find out

Chronic pain is common in individuals with opioid use disorder (OUD) and the first-line treatment, Medication for OUD (MOUD), does not address the considerable functional impairments associated with chronic pain. Veterans with OUD and chronic pain could benefit from integrated, behavioral treatment for chronic pain and addiction, but VHA MOUD clinics often lack the resources to offer these services. The proposed study will examine the effectiveness of an evidence-based digital chronic pain and addiction treatment that Veterans can do from home, which can provide a flexible option for Veterans to engage in treatment from home and the Veterans Health Administration (VHA) a means to provide care without placing trained clinicians at each facility.

The 2 groups in the trial

  • IMPACTTreatment being tested

    Data from Veteran participants randomized to digital intervention (IMPACT)

    Treatment: Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT)

  • ETAUPlacebo, for comparison

    Data from Veteran participants randomized to ETAU (no access to IMPACT)

    Treatment: Enhanced Treatment as Usual (ETAU)

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Improving Pain and Functioning Using an Integrative Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine
Record updated
13 November 2026