Tests a probiotic supplement in people with diabetic macular edema
Tests Lactobacillus plantarum 299v, taken by mouth, in adults with diabetic macular edema.
Plain-language title generated from the registry record
Registry title: Lactiplantibacillus Plantarum 299v Probiotic Supplementation in Patients With Diabetic Macular Edema
Key facts
- Where
- Boston, United StatesSee the site
- Phase
- Phase 2
Where in United States
- Mass Eye and EarBoston, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Massachusetts Eye and Ear Infirmary
- Trial code
- NCT07383701
- Record updated
- 30 September 2026
- Original description
This pilot prospective, interventional, longitudinal study, aims to evaluate the potential benefits of the probiotic supplement Lactobacillus plantarum 299v in patients with diabetic macular edema (DME).Read full original descriptionShow less
Lactiplantibacillus Plantarum 299v Probiotic Probiotic Supplementation in Patients With Diabetic Macular Edema
This pilot prospective, interventional, longitudinal study, aims to evaluate the potential benefits of the probiotic supplement Lactobacillus plantarum 299v in patients with diabetic macular edema (DME).
The study seeks to address the following questions:
1. Does central macular thickness on optical coherence tomography decrease after 4 months of supplementation? 2. Is visual acuity improved at 1, 2, 3, and 4 months following initiation of supplementation? 3. Is the number of anti-VEGF injections reduced following initiation of supplementation?
Outcomes will be compared to a control group, using historic retrospective data.
Participants will take Lactobacillus plantarum 299v orally twice daily for four months.
Inclusion: Age of at least 18 years, presence of DME at the current clinical visit.
Exclusion: Patients with contraindication to probiotic supplement (e.g. prior allergy or GI intolerance and any type of immunocompromised diseases).