Diabetic eye disease trials in United States

In United States 47 Also abroad 142

47 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
A Phase 3 Trial for Intravitreal Injection of 4D-150 in Adults With Diabetic Macular Edema (DME).
Where
Abilene, Asheville, Aurora, Austin, Bethlehem, Bloomfield, Bluffton, Carmel, Cary, Charleston, Chevy Chase, Colorado Springs, Dallas, Durango, Edison, Edmund, Elmhurst, Encino, Fairfax, Fort Lauderdale, Fullerton, Greenwich, Hagerstown, Houston, Huntington Beach, Katy, Lemont, Lynchburg, Madison, Middleburg Heights, Nashville, New York, Oak Park, Orlando, Pensacola, Philadelphia, Plantation, Portland, Rapid City, Reno, Sacramento, San Diego, San Mateo, Scottsdale, Southaven, Springfield, St Louis, Tampa, The Woodlands, Tyler, Wake Forest, Walnut Creek, Waterford, Wausau, Westbury
Age
18 years and over
People
514 worldwide
Run by
4D Molecular Therapeutics
See details and how to joinNCT07867080
Phase 1Taking people
A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RO7823653 in Participants With Diabetic Macular Edema (DME)
Where
Abilene, Austin, Baltimore, Beverly Hills, Erie, Germantown, Lynchburg, Peoria, Philadelphia, San Antonio, St. Petersburg, Walnut Creek
Age
18 years and over
People
93
Run by
Genentech, Inc.
See details and how to joinNCT07425522
Phase 1Taking people
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of RO7663498 Following Intravitreal Administration in Participants With Diabetic Retinopathy
Where
Columbus, Glendale, Oak Forest, San Antonio
Age
18 years and over
People
30
Run by
Hoffmann-La Roche
See details and how to joinNCT07588100
No phaseTaking people
Implementing AI-based Glaucoma Screening Within Federally Qualified Health Centers
Where
Birmingham
Age
18 years and over
People
1,800
Run by
University of Alabama at Birmingham
See details and how to joinNCT06629649
Phase 3Taking people
A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-004)
Where
Austin, Bellaire, Bloomfield, Bluffton, Carmel, Charleston, Cherry Hill, Denver, Florence, Gainesville, Gilbert, Glendale, Hagerstown, Johnson City, Knoxville, Lenexa, Madison, Manchester, Mt. Pleasant, Palm Beach Gardens, Rochester, Sacramento, San Marcos, Schertz, Tampa, Towson, Wake Forest, West Columbia, Wildwood
Age
18 years and over
People
960 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07705555 · EU 2026-526790-42-01
Phase 3Taking people
A Clinical Trial of MK-8748 Compared to Aflibercept in Participants With Diabetic Macular Edema (MK-8748-005)
Where
Aiken, Arlington, Beaufort, Carmel, Charleston, Fort Worth, Greenville, Hagerstown, Hickory, Katy, Ladson, Liverpool, Long Beach, Orlando, Southlake, St. Petersburg, Waterford, West Des Moines, Winston-Salem, Winter Haven
Age
18 years and over
People
1,104 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07705607 · EU 2026-526787-20-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of Tabirafusp Tedromer Compared to Aflibercept in Participants With DME - ALTO
Where
Amarillo, Arlington, Austin, Bakersfield, Beaufort, Bellaire, Bellevue, Cary, Charleston, Elmhurst, Fort Lauderdale, Fort Worth, Glendale, Greensboro, Hagerstown, Hauppauge, Hickory, Katy, Ladson, Lynchburg, Madison, Modesto, Mt. Pleasant, Oxnard, Pasadena, Plano, Redlands, Rochester, Round Rock, Sacramento, Saint Louis Park, San Antonio, Schertz, Scottsdale, Sioux Falls, St. Petersburg, The Woodlands, Wake Forest, Waterford, West Columbia, Winston-Salem, Winter Haven
Age
18 years and over
People
910 worldwide
Run by
Kodiak Sciences Inc
See details and how to joinNCT07734844
Phase 2/3Taking people
Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema
Where
Augusta, Austin, Bakersfield, Bellaire, Beverly Hills, Bloomfield, Burleson, Campbell, Charleston, Chicago, Dallas, Durango, Encino, Hagerstown, Lakeland, Lakewood, Lemont, Lenexa, Longmont, Mesa, Middleburg Heights, Mountain View, Norfolk, Orlando, Pasadena, Pensacola, Phoenix, Portland, Poway, Reno, Sacramento, Salem, San Francisco, Santa Barbara, Scottsdale, Springfield, Torrance, Walnut Creek
Age
18 years and over
People
576 worldwide
Run by
AbbVie
See details and how to joinNCT07592273
Phase 2Taking people
A Study to Test Whether BI 764524 Helps People With an Eye Condition Called Diabetic Retinopathy
Where
‘Aiea, Austin, Bakersfield, Beverly Hills, Campbell, Cleveland, Encino, Glendale, Great Neck, Hagerstown, Huntington Beach, Jacksonville, Katy, Ladson, Lakeland, Lakewood, Liverpool, McAllen, Nashville, Palo Alto, Pasadena, Phoenix, Portland, Round Rock, Sacramento, Salt Lake City, San Antonio, Santa Maria, Schertz, Southaven, Stuart, Teaneck, Walnut Creek, Waterford, Winter Haven
Age
18 years and over
People
175 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06321302 · EU 2023-508891-12-00
Phase 2Taking people
A Randomized, Phase 2 Study of Oral BGE-102 in Participants With Center-Involved Diabetic Macular Edema
Where
Abilene, Austin, Bakersfield, Cary, Fort Myers, Glendale, Houston, Ladson, Laredo, McAllen, Mountain View, San Antonio, South Miami, The Woodlands, Wake Forest, West Monroe
Age
18 years to 75 years
People
180
Run by
BioAge Labs, Inc.
See details and how to joinNCT07812090
No phaseTaking people
National Eye Institute Biorepository for Retinal Diseases
Where
Bethesda
Age
2 years to 120 years
People
650
Run by
National Eye Institute (NEI)
See details and how to joinNCT01496625
No phaseTaking people
Human iPSC for Repair of Vasodegenerative Vessels in Diabetic Retinopathy
Where
Birmingham
Age
21 years to 98 years
People
20
Run by
University of Alabama at Birmingham
See details and how to joinNCT03403699
Phase 4Taking people
Longitudinal Study of Retinal Function in Eyes Treated for Diabetic Macular Edema With Anti-VEGF Agents
Where
Augusta, Beaumont, Boston, Detroit, Huntington Beach, Monroeville, Rochester, Sewickley
Age
18 years and over
People
100
Run by
Jaeb Center for Health Research
See details and how to joinNCT07567833
Phase 4Not yet taking people in United States
Iopidine to Decrease Intraocular Pressure Rise After Injections
Where
Easton
Age
18 years and over
People
120
Run by
Retina Consultants of Delmarva
See details and how to joinNCT07891910
No phaseTaking people
Leveraging Artificial Intelligence to Prevent Vision Loss From Diabetes
Where
Madison
Age
22 years and over
People
6,900
Run by
University of Wisconsin, Madison
See details and how to joinNCT06763952
No phaseTaking people
Intraoperative OCT Guidance of Intraocular Surgery II
Where
Durham
Age
4 weeks and over
People
262
Run by
Duke University
See details and how to joinNCT03713268
Phase 1Taking people
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for NAION
Where
Naples
People
20 worldwide
Run by
The Foundation for Orthopaedics and Regenerative Medicine
See details and how to joinNCT05147701
Phase 2Taking people
A Study to Test Whether BI 1815368 Helps People With an Eye Condition Called Diabetic Macular Edema
Where
Arcadia, Augusta, Austin, Beaumont, Carmel, Charleston, Cleveland, Dallas, Danbury, Eugene, Fort Lauderdale, Greenville, Hagerstown, Huntington Beach, Jacksonville, Kansas City, Lakewood, Lynchburg, Modesto, Nashville, Newport Beach, Pasadena, Phoenix, Pompano Beach, Poway, Reno, San Antonio, San Francisco, Southlake, Stuart, The Woodlands, Wake Forest, Winter Haven
Age
18 years and over
People
300 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06962839 · EU 2024-520384-14-00
Phase 1/2Taking people
A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated
Where
Arcadia, Austin, Bellaire, Beverly Hills, Cleveland, Eugene, Falls Church, Fargo, Fort Myers, Glendale, Huntington Beach, Lakeland, McAllen, Nashville, Oceanside, Oxnard, Phoenix, Portland, Sacramento, San Antonio, Scottsdale, Stuart, The Woodlands, Wake Forest, Walnut Creek, Waterford, Willow Park
Age
18 years and over
People
49 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT07553429
Phase 4Not yet taking people in United States
Continuous Delivery of Ranibizumab Via the Port Delivery System for Proliferative Diabetic Retinopathy-related Vitreous Hemorrhage With Pars Plana Vitrectomy and Limited PRP.
Where
Augusta
Age
18 years and over
People
20
Run by
Southeast Retina Center, Georgia
See details and how to joinNCT07864480
Phase 2Taking people
Lactiplantibacillus Plantarum 299v Probiotic Supplementation in Patients With Diabetic Macular Edema
Where
Boston
Age
18 years and over
People
36
Run by
Massachusetts Eye and Ear Infirmary
See details and how to joinNCT07383701
No phaseTaking people
Liver X Receptor (LXR) as a Novel Therapeutic Target in Diabetic Retinopathy (DR)
Where
Birmingham
Age
21 years to 98 years
People
104
Run by
University of Alabama at Birmingham
See details and how to joinNCT03403686
Phase 4Taking people
Corticosteroid for Diabetic Macular Edema (DME) Study
Where
Nashville
Age
18 years and over
People
20
Run by
Vanderbilt University Medical Center
See details and how to joinNCT07843849
No phaseTaking people
Pivotal Trial for an Automated AI-based System for Detection of Diabetic Retinopathy
Where
Jacksonville
Age
22 years and over
People
800
Run by
Digital Diagnostics, Inc.
See details and how to joinNCT07844317
No phaseTaking people
ACCESS 2: AI for pediatriC diabetiC Eye examS Study 2
Where
Baltimore
Age
8 years to 21 years
People
500
Run by
Johns Hopkins University
See details and how to joinNCT05463289