Frontlight ResearchEarly access
Not yet taking people in United StatesPhase 4
Examining Analgesic Synergy and Efficacy in Trauma Care
Key facts
- Who runs it
- Wake Forest University Health Sciences
- Where
- Winston-Salem, United StatesSee the site
- Trial code
- Status
- Not yet recruiting
- Phase
- Phase 4
- People taking part
- 282 people, planned
- Starts
- Mar 2027
- Expected to end
- Jul 2027
- Type of study
- Interventional, 2 groups
- Treatments tested
- Buprenorphine
- Oxycodone
- Record updated
- 28 October 2026
Who can take part
- Age
- 18 years to 80 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 13 criteriaShow less
Who can take part
- Adult patients with injury to at least 2 body locations as defined by Abbreviated Injury Scale (AIS) scores (Head, Face, Neck, Chest, Abdomen/Pelvis, Spine, Upper Extremity, Lower Extremity, External)
Who cannot take part
- Allergy to any medication within the study or control arm
- History of cirrhosis requiring dose adjustment of Tylenol
- Age <18 years
- Age ≥80years
- Glasgow Coma Scale (GCS) <15 - Patients may be included if their GCS improves to 15 within 24 hours of admission
- Prisoners
- Pregnant patients
- Non-English speakers
- Inability to provide consent
- Home buprenorphine or methadone use
- Home opioid use >45 Morphine Milligram Equivalents (MME)/day
- Patients undergoing treatment for alcohol withdrawal
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Where in United States
- Wake Forest University Health SciencesWinston-Salem, United StatesContact: D'Ann B Hershel, MSNot yet recruiting
About the trial
What the trial wants to find out
Traumatic injury is responsible for over 25 million (16%) Emergency Department visits and over 225,000 deaths each year per 2021 Center for Disease Control data. This is the 3rd leading cause of death in the US. Often, acute care for the injured patient requires administration of pain medication for the purposes of acute pain control from injury. The mainstay of treatment for pain control has historically involved opioid pain medication.
The 2 groups in the trial
- Control groupOther group
Standard pain control regimen with oxycodone
Treatment: Oxycodone
- Study groupTreatment being tested
Standard pain control regimen with buprenorphine
Treatment: Buprenorphine
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Examining Analgesic Synergy and Efficacy in Trauma Care-A Randomized, Control Study of Buprenorphine Versus Oxycodone in Multimodal Pain Control Regimens
- Fit questions
- Built from NCT07435077, who can take part
- Record updated
- 28 October 2026