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Personalized Closed-Loop Brain Stimulation for Patients With Mild Cognitive Impairment

Key facts

Who runs it
Johns Hopkins University
Where
Baltimore, United StatesSee the site
Trial code
Status
Not yet recruiting
People taking part
10 people, planned
Started
Nov 2026
Expected to end
Dec 2026
Type of study
Interventional
Treatments tested
  • Active tES
  • Cognitive Interventions
Record updated
7 October 2026

Who can take part

Age
45 years to 85 years
Sex
Women and men
Healthy volunteers
Can take part

The registry criteria, word for word

Show all 10 criteriaShow less

Who can take part

  • Must be between 45-85 years of age
  • Must be proficient in English
  • Must have a minimum of high-school education
  • Must be diagnosed with 'probable Alzheimer's Disease (AD)' in specialized diagnostic centers with neuropsychological (e.g., RAVLT) and AD biomarkers according to 2011 guidelines
  • The investigators will also perform extensive testing in the investigators' test battery including the Mnemonic Similarity Test (MST) that discriminates and measures the most salient hippocampal deficit-pattern separation (PS)

Who cannot take part

  • People with previous neurological disease including vascular dementia (e.g., stroke, developmental dyslexia, dysgraphia or attentional deficit)
  • People with advanced dementia or severe language impairments (MMSE <15, or Montreal Cognitive Assessment <10, or language Frontotemporal Dementia-specific Clinical Dementia Rating (FTD-CDR) =3)
  • People with pre-existing psychiatric disorders such as behavioral disturbances, severe depression, or schizophrenia that do not allow these people to comply or follow the study schedule and requirements such as repeated evaluation and therapy
  • People with hearing loss (> 25 decibel, using audiometric hearing screen)
  • People with uncorrected visual acuity loss

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 45 and 85 years old?

Where in United States

  • Johns Hopkins HospitalBaltimore, United StatesContact: Kyrana Tsapkini, PhDNot yet recruiting

About the trial

What the trial wants to find out

This research study investigates the feasibility and efficacy of a personalized, closed-loop electroencephalogram-transcranial electrical stimulation (EEG-tES) intervention for individuals with mild cognitive impairment (MCI), addressing the inconsistent results of generic brain stimulation protocols. By integrating artificial intelligence (AI)-derived insights with real-time data, the study aims to customize transcranial electrical stimulation (tES) parameters, including electrode placement, intensity, and frequency to target the specific brain regions responsible for abnormal signaling in each participant. Over the intervention period paired with computerized cognitive training, the project will evaluate improvements in learning, memory, and functional connectivity, while simultaneously identifying clinical and physiological predictors to determine the viability of transitioning this low-cost, non-invasive technology into a remotely supervised, home-based therapy setting. The study duration will be a total of 6-8 weeks.

The group in the trial

  • Personalized closed-loop tES treatment + Cognitive InterventionsTreatment being tested

    Participants will receive personalized, closed-loop active tES for 3 weeks. Active tES will be administered for 20 minutes. Cognitive training exercises will be administered concurrently with the tES and will take approximately 30 minutes to complete.

    Treatment: Active tES and Cognitive Interventions

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Fit questions
Built from NCT07512193, who can take part
Record updated
7 October 2026
Personalized Closed-Loop Brain Stimulation for Patients With Mild Cognitive Impairment (NCT07512193) – Frontlight Research