Brain and Sensory Stimulation for Language and Memory in Primary Progressive Aphasia
Tests brain and sensory stimulation on verbal memory in people with primary progressive aphasia.
Plain-language title generated from the registry record
Registry title: Stimulating the Aging Brain Using Brain and Sensory Stimulation
Key facts
- Where
- Milwaukee, United StatesSee the site
Where in United States
- Medical College of WisconsinMilwaukee, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Medical College of Wisconsin
- Trial code
- NCT07650188
- Record updated
- 16 June 2026
- Original description
The goal of this project is to investigate whether transcranial electrical stimulation and sensory stimulation affect language outcomes in individuals with primary progressive aphasia (PPA). The main questions it aims to answer are:Read full original descriptionShow less
Stimulating the Aging Brain: Noninvasive Brain and Sensory Stimulation Strategies in Aging
The goal of this project is to investigate whether transcranial electrical stimulation and sensory stimulation affect language outcomes in individuals with primary progressive aphasia (PPA). The main questions it aims to answer are:
Does transcranial alternating current stimulation (tACS) affect verbal short-term memory (STM) in individuals with PPA? Does a single session of multisensory stimulation affect verbal STM in individuals with PPA? Researchers will compare active tACS to sham tACS (a fake stimulation condition) to see if active tACS improves verbal STM. Researchers will compare pre-multisensory stimulation to post-stimulation performance to see if multisensory stimulation improves verbal STM.
Participants will:
Undergo EEG, MRI (anatomical and functional) May complete a cognitive exam Undergo tACS over 3 separate sessions Undergo multisensory stimulation Complete language tasks before, during and/or after stimulation
Inclusion: Clinical exam supports diagnosis of PPA and/or MCI with no report of difficulty functioning in basic or instrumental activities of daily living; Completed clinical cognitive exam within 6 months of study baseline visit OR neuropsychological research battery within 6 months of study baseline visit.
Exclusion: Any other implants near the scalp or in the eye; Evidence of dementia at baseline; Known history of neoplasm, symptomatic stroke, moderate to severe traumatic brain injury, or other significant neurologic event; Evidence of severe psychiatric illness (e.g., bipolar disorder, schizophrenia); Presence of cardiac stimulators or pacemakers; History of ongoing or unmanaged seizures; History of dyslexia or other developmental learning disabilities; Age <45 years; Contraindications to MRI or stimulation; Pregnancy.