Testing relatives of people with familial hypercholesterolemia to find those at risk
Compares two ways of testing family members of people with familial hypercholesterolemia.
Plain-language title generated from the registry record
Registry title: Cascade Testing In Identifying At-risk Family Members Of Individuals With Familial Hypercholesterolemia (FH) In PCP
Key facts
- Where
- Rochester, United StatesSee the site
Where in United States
- Mayo Clinic in RochesterRochester, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Mayo Clinic
- Trial code
- NCT07653555
- Record updated
- 18 September 2026
- Original description
The purpose of this study is to evaluate the effectiveness of two models of cascade testing in identifying at-risk family members of individuals diagnosed with familial hypercholesterolemia (FH).Read full original descriptionShow less
A Cluster Randomized Controlled Trial To Evaluate The Efficacy Of Cascade Testing In Identifying At-risk Family Members Of Individuals With Familial Hypercholesterolemia (FH) In PCP
The purpose of this study is to evaluate the effectiveness of two models of cascade testing in identifying at-risk family members of individuals diagnosed with familial hypercholesterolemia (FH).
Inclusion: Index Patients:; Age ≥ 18 years; Confirmed FH diagnosis using Dutch Lipid Clinic Network criteria *or* genetic confirmation; Identified through REP or Tapestry databases; Able and willing to provide informed consent; At least one eligible first- or second-degree relative; Access to and active use of email (computer literacy requirement); Relatives:; First- or second-degree relative of an enrolled index patient; Age ≥ 1 year (minors require parental consent + assent); Willing to participate and able to complete electronic consent (guardian-assisted if minor); Access to and active use of email (guardian).
Exclusion: Prior participation in structured cascade testing; Prior participation in structured cascade testing; Severe cognitive impairment preventing informed consent; Relatives:; Severe cognitive impairment preventing informed consent; Insufficient clinical follow-up (<5 years); Index Patients:; No confirmed FH diagnosis; No identifiable or contactable relatives.