Familial hypercholesterolaemia trials in United States

In United States 40 Also abroad 115

40 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2/3Taking people
A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029)
Where
Atlanta, Boca Raton, Boston, Cincinnati, Morgantown, St Louis, Washington D.C., Wilmington
Age
6 years to 17 years
People
153 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07058077 · EU 2024-519068-42-00
Phase 2Taking people
A Study of VERVE-102 (LY4636581) in Adults With or at High Risk for Cardiovascular Disease
Where
DeSoto
Age
18 years to 70 years
People
175
Run by
Verve Therapeutics, Inc.
See details and how to joinNCT07839936 · EU 2026-525691-26-00
No phaseTaking people
Causes and Natural History of Dyslipidemias
Where
Bethesda
Age
2 years to 100 years
People
2,000
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT00353782
No phaseNot yet taking people in United States
Penn Family Screening for Familial Hypercholesterolemia (NHLBI R33) Trial 3
Where
Philadelphia
Age
18 years and over
People
110
Run by
Northwestern University
See details and how to joinNCT07919353
No phaseTaking people
Pharmacogenomic Informed Statin Prescribing
Where
Durham, Indianapolis
Age
40 years to 75 years
People
214
Run by
VA Office of Research and Development
See details and how to joinNCT06568601
Phase 4Taking people
Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention
Where
Albany, Albuquerque, Alexander City, Amarillo, Anderson, Asheville, Aurora, Austin, Avondale, Bangor, Bethlehem, Beverly Hills, Birmingham, Bossier City, Bridgeport, Bridgewater, Buffalo, Camp Hill, Canton, Chambersburg, Charlotte, Chicago, Chula Vista, Clearwater, Clinton, Columbia, Concord, Conroe, Coral Gables, Covina, Covington, Danbury, Daytona Beach, Duluth, Elkhart, Elmer, Englewood, Fayetteville, Flemington, Gainesville, Germantown, Glendora, Grand Island, Green Bay, Greeneville, Greensboro, Haddon Heights, High Point, Houston, Humble, Huntsville, Jackson, Jacksonville, Jonesboro, Kingwood, Lancaster, Lanham, Lansing, Largo, Lebanon, Lincoln, Little Rock, Lufkin, Mankato, McAllen, Merrillville, Miami Lakes, Midland, Milwaukee, Morrisville, Murray, Nashville, New Orleans, Newport Beach, Newport News, New York, Norfolk, Northridge, Oklahoma City, Omaha, Overland Park, Owensboro, Panama City, Park Ridge, Peachtree City, Peoria, Pomona, Pontiac, Port Charlotte, Poughkeepsie, Puyallup, Raleigh, Rapid City, Richmond, Riverside, Rochester, Rochester Hills, Rockford, Rockville, Round Rock, Safety Harbor, Salisbury, San Diego, San Francisco, San Marcos, Sewell, Shreveport, Silver Spring, Southaven, Springfield, Stamford, Staten Island, Tacoma, Takoma Park, Tampa, The Bronx, Thornton, Toledo, Tomball, Torrance, Tucker, Tupelo, Van Nuys, Ventura, West Des Moines, West Hills, West Monroe, West Reading, Wichita, Winchester, Winston-Salem, York, Zanesville
Age
18 years and over
People
6,000
Run by
Duke University
See details and how to joinNCT06909565
Phase 3Taking people
Study of Zodasiran in Adolescent Participants With Homozygous Familial Hypercholesterolemia
Where
St Louis
Age
12 years to 17 years
People
10 worldwide
Run by
Arrowhead Pharmaceuticals
See details and how to joinNCT07473843 · EU 2025-523662-24-00
Phase 1Taking people
Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia
Where
Clearwater, Garden Grove, Miami Lakes, New York, Port Orange
Age
18 years to 70 years
People
132 worldwide
Run by
Verve Therapeutics, Inc.
See details and how to joinNCT06451770 · EU 2025-522617-39-00
No phaseTaking people
Test 2 Treat: Can we Improve the Testing and Treatment of High Cholesterol in Patients Who Have Been Hospitalized for a Cardiac Event by Providing Education to Doctors and Patients?
Where
Minneapolis
Age
18 years and over
People
400
Run by
Duke University
See details and how to joinNCT06471036
No phaseTaking people
The ORIGIN-FH Study
Where
Madison
Age
18 years and over
People
70
Run by
University of Wisconsin, Madison
See details and how to joinNCT07470723
No phaseTaking people
Computerized Decision Support for Identification and Management of Familial Hypercholesterolemia
Where
Boston
People
450
Run by
Brigham and Women's Hospital
See details and how to joinNCT06743659
Phase 3Taking people
Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 Studies
Where
Boca Raton, Cincinnati, New York, Pittsburgh, Salt Lake City
Age
2 years to 100 years
People
195 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT05682378
Phase 1Taking people
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
Where
Durham, Hialeah, High Point, Jacksonville, Orlando, Portland, Port Orange, Rochester
Age
18 years to 75 years
People
90 worldwide
Run by
CRISPR Therapeutics AG
See details and how to joinNCT07491172
No phaseNot yet taking people in United States
Cascade Testing In Identifying At-risk Family Members Of Individuals With Familial Hypercholesterolemia (FH) In PCP
Where
Rochester
Age
1 year and over
People
480
Run by
Mayo Clinic
See details and how to joinNCT07653555
Phase 1Taking people
A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease
Where
Boca Raton, DeSoto, Dothan, High Point, Indianapolis, Jacksonville, Philadelphia, Pomona, Renton, Winter Park
Age
18 years to 70 years
People
85 worldwide
Run by
Verve Therapeutics, Inc.
See details and how to joinNCT06164730
Phase 2Taking people
2-Hydroxybenzylamine (2-HOBA) to Reduce HDL Modification and Improve HDL Function in Familial Hypercholesterolemia (FH)
Where
Nashville
Age
18 years to 69 years
People
72
Run by
Vanderbilt University Medical Center
See details and how to joinNCT04941599
Phase 2Taking people
A Study to Evaluate the Pharmacodynamics of a Combination of QCZ484 and Inclisiran in Participants With Hypertension and Concomitant Hypercholesterolemia
Where
Boca Raton, Brandon, Canton, Chicago, Cooper City, Coral Gables, Doral, Foley, Ft. Washington, Houston, Jacksonville, Lanham, Lincoln, Little River, Los Angeles, Manassas, Miami, Miami Lakes, Monroe, Niles, Northridge, Pembroke Pines, Richmond, Saint Augustine, Saraland, West Monroe, Wichita
Age
18 years to 75 years
People
120
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07610278
Phase 3Enrolling by invitation
Study to Evaluate the Efficacy and Safety of Lerodalcibep in Children 6 to 17 Years, With Heterozygous FH
Where
Cincinnati
Age
6 years to 17 years
People
150 worldwide
Run by
LIB Therapeutics LLC
See details and how to joinNCT07102511 · EU 2025-524214-28-00
Phase 3Taking people
Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia
Where
Salt Lake City, San Francisco, St Louis, Washington D.C.
Age
2 years to 11 years
People
9 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06597006
No phaseTaking people
Pilot Study of "Bottarga" Supplementation: A Little-known, Sustainable "Blue" Food
Where
Sommerville
Age
18 years to 60 years
People
20
Run by
Cambridge Health Alliance
See details and how to joinNCT06988462
No phaseEnrolling by invitation
Advancing Care Coordination Between Cancer and Primary Care Teams for Complex Cancer Survivors
Where
New Brunswick
Age
18 years and over
People
266
Run by
Rutgers, The State University of New Jersey
See details and how to joinNCT06834204
No phaseEnrolling by invitation
Improving Lipid Optimization Quality and Treatment Options in ASCVD
Where
Boston
Age
18 years to 95 years
People
300
Run by
Brigham and Women's Hospital
See details and how to joinNCT06960655
Phase 2Not yet taking people in United States
Use of Bile Acid Binding Resins to Decrease PFAS Levels Via Colesevalem in Veterans Study
Where
Augusta, Louisville
Age
25 years to 65 years
People
50
Run by
University of Rhode Island
See details and how to joinNCT07592858
Phase 3Taking people
Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia
Where
Boca Raton, Morgantown, New York, Richmond, Salt Lake City, San Francisco, Washington D.C.
Age
6 years to 11 years
People
60 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06597019
No phaseEnrolling by invitation
Virtual Lifestyle Intervention for Weight Management and Cardiovascular Heal
Where
San Francisco
Age
30 years to 60 years
People
200
Run by
Truemedicine Inc
See details and how to joinNCT07572721