Compares tabirafusp tedromer with aflibercept for diabetic macular edema
Tests tabirafusp tedromer against aflibercept in adults with diabetic macular edema.
Plain-language title generated from the registry record
Registry title: A Study to Evaluate the Efficacy and Safety of Tabirafusp Tedromer Compared to Aflibercept in Participants With DME - ALTO
Key facts
- Where
- Amarillo, Arlington, Austin, Bakersfield, Beaufort, Bellaire, Bellevue, Cary, Charleston, Elmhurst, Fort Lauderdale, Fort Worth, Glendale, Greensboro, Hagerstown, Hauppauge, Hickory, Katy, Ladson, Lynchburg, Madison, Modesto, Mt. Pleasant, Oxnard, Pasadena, Plano, Redlands, Rochester, Round Rock, Sacramento, Saint Louis Park, San Antonio, Schertz, Scottsdale, Sioux Falls, St. Petersburg, The Woodlands, Wake Forest, Waterford, West Columbia, Winston-Salem, and Winter Haven, United StatesSee the 42 sites
- Phase
- Phase 3
Where in United States
- Kodiak Research CenterAmarillo, United StatesTaking people
- Kodiak Research CenterArlington, United StatesTaking people
- Kodiak Research CenterAustin, United StatesTaking people
- Kodiak Research CenterBakersfield, United StatesTaking people
- Kodiak Research CenterBeaufort, United StatesTaking people
- Kodiak Research CenterBellaire, United StatesTaking people
- Kodiak Research CenterBellevue, United StatesTaking people
- Kodiak Research CenterCary, United StatesTaking people
- Kodiak Research CenterCharleston, United StatesTaking people
- Kodiak Research CenterElmhurst, United StatesTaking people
- Kodiak Research CenterFort Lauderdale, United StatesTaking people
- Kodiak Research CenterFort Worth, United StatesTaking people
- Kodiak Research CenterGlendale, United StatesTaking people
- Kodiak Research CenterGreensboro, United StatesTaking people
- Kodiak Research CenterHagerstown, United StatesTaking people
- Kodiak Research CenterHauppauge, United StatesTaking people
- Kodiak Research CenterHickory, United StatesTaking people
- Kodiak Research CenterKaty, United StatesTaking people
- Kodiak Research CenterLadson, United StatesTaking people
- Kodiak Research CenterLynchburg, United StatesTaking people
- Kodiak Research CenterMadison, United StatesTaking people
- Kodiak Research CenterModesto, United StatesTaking people
- Kodiak Research CenterMt. Pleasant, United StatesTaking people
- Kodiak Research CenterOxnard, United StatesTaking people
- Kodiak Research CenterPasadena, United StatesTaking people
- Kodiak Research CenterPlano, United StatesTaking people
- Kodiak Research CenterRedlands, United StatesTaking people
- Kodiak Research CenterRochester, United StatesTaking people
- Kodiak Research CenterRound Rock, United StatesTaking people
- Kodiak Research CenterSacramento, United StatesTaking people
- Kodiak Research CenterSaint Louis Park, United StatesTaking people
- Kodiak Research CenterSan Antonio, United StatesTaking people
- Kodiak Research CenterSchertz, United StatesTaking people
- Kodiak Research CenterScottsdale, United StatesTaking people
- Kodiak Research CenterSioux Falls, United StatesTaking people
- Kodiak Research CenterSt. Petersburg, United StatesTaking people
- Kodiak Research CenterThe Woodlands, United StatesTaking people
- Kodiak Research CenterWake Forest, United StatesTaking people
- Kodiak Research CenterWaterford, United StatesTaking people
- Kodiak Research CenterWest Columbia, United StatesTaking people
- Kodiak Research CenterWinston-Salem, United StatesTaking people
- Kodiak Research CenterWinter Haven, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Kodiak Sciences Inc
- Trial code
- NCT07734844
- Record updated
- 3 November 2026
- Original description
A Study to Evaluate the Efficacy and Safety of Tabirafusp Tedromer Compared to Aflibercept in Participants with Diabetic Macular Edema - ALTORead full original descriptionShow less
A Randomized, Double-masked, Active-controlled, Multi-center, Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal Tabirafusp Tedromer 5 mg Compared With Intravitreal Aflibercept 2 mg in Participants With Visual Impairment Secondary to Diabetic Macular Edema (DME) - ALTO
A Study to Evaluate the Efficacy and Safety of Tabirafusp Tedromer Compared to Aflibercept in Participants with Diabetic Macular Edema - ALTO
Inclusion: DME, treatment-naïve or previously-treated; Male or female ≥18 years of age with Type 1 or Type 2 diabetes mellitus and a HbA1c of ≤12%; Capable of giving informed signed consent.
Exclusion: Current or history of retinal detachment (tractional or rhegmatogenous) in the Study Eye; Active iris or angle neovascularization or neovascular glaucoma in the Study Eye.