Varenicline for Smoking Cessation in Pancreatitis

Who can take part

• Provision of signed and dated informed consent form
• Stated willingness to comply with all study procedures and availability for the duration of the study
• Male or female, aged 18 or older
• Diagnosed with either acute pancreatitis, recurrent acute pancreatitis or chronic pancreatitis as defined by the American Pancreatic Association
• Currently smoking cigarettes daily or on most days, with an average of ≥5 cigarettes/day over the past 30 days
• Explicitly express a desire to quit within 30 days
• Ability to take oral medication and be willing to adhere to the study intervention regimen
• Willing and able to comply with trial protocol and follow-up

Who cannot take part

• Known hypersensitivity to varenicline
• Active seizure disorder or other medical condition judged by the investigator to make varenicline unsafe
• Current untreated psychotic disorder or acute manic episode that would interfere with participation or safe medication use
• History of chronic kidney disease (creatinine clearance < 30 mL/minute)
• Age < 18 years of age
• No desire to quit smoking within 30 days
• Unable to provide informed consent