Alzheimer disease trials in Spain

In Spain 58 Also abroad 815

58 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 12 November 2026. Ask the study team whether a trial fits you.

No phaseEnrolling by invitation
Digitally-enhanced, Decentralized, Multi-omics Observational Cohort
Where
Barcelona
Age
45 years and over
People
100,000 worldwide
Run by
Greece 2021 Committee
See details and how to joinNCT04701177
Phase 2Taking people
Brain imaging to understand early changes in dementia related diseases
Where
Barcelona
Age
18 years and over
People
300
Run by
Barcelonabeta Brain Research Center
See details and how to join2025-523284-37-00 · EU 2025-523284-37-00
Phase 2Taking people
A study to assess the efficacy and safety of ITI-1284 in the treatment of Psychosis Associated with Alzheimer's Disease
Where
Albacete, Getafe, Madrid, Melilla, Zamora, Zaragoza
Age
18 years and over
People
216 worldwide
Run by
Intra-Cellular Therapies Inc.
See details and how to join2024-513035-25-00 · EU 2024-513035-25-00
No phaseTaking people
Study of the Brain's Natural Cleaning System in Potential Organ Donors.
Where
Badalona
People
10
Run by
Germans Trias i Pujol Hospital
See details and how to joinNCT07682155
Phase 3Taking people
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)
Where
Barcelona, Madrid, Salamanca, Seville, Valladolid, Zamora, Zaragoza
Age
55 years to 90 years
People
410 worldwide
Run by
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
See details and how to joinNCT05511363
No phaseNot yet taking people in Spain
PENSA+: Extended Follow-up of a Multimodal Lifestyle Intervention to Prevent Cognitive Decline in APOE-ε4 Carriers
Where
Barcelona
Age
60 years and over
People
121
Run by
Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
See details and how to joinNCT07730671
Phase 2/3Taking people
A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
Where
Barcelona
Age
18 years and over
People
280 worldwide
Run by
Washington University School of Medicine
See details and how to joinNCT05552157
Phase 2/3Taking people
A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
Where
Barcelona
Age
18 years and over
People
280 worldwide
Run by
Washington University School of Medicine
See details and how to joinNCT06647498
Phase 1/2Taking people
A Study to Assess the Effects of ACI-24.060 in Alzheimer's Disease and in Down Syndrome (ABATE Study)
Where
Barcelona, Granada, Madrid, Santander, Valencia
Age
35 years to 85 years
People
304 worldwide
Run by
AC Immune SA
See details and how to joinNCT05462106 · EU 2022-500069-29-00
No phaseEnrolling by invitation
Home-Based Closed-Loop Auditory Stimulation to Enhance Slow-Wave Activity in MCI Due to Alzheimer's Disease: A Proof-of-Concept Study
Where
Zaragoza
Age
50 years to 75 years
People
30
Run by
Bitbrain
See details and how to joinNCT07672977
No phaseNot yet taking people in Spain
Intervention to Reduce Unwanted Loneliness in Family Caregivers of People With Alzheimer
Where
Valencia
Age
65 years and over
People
50
Run by
University of Valencia
See details and how to joinNCT07639645
No phaseTaking people
Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia
Where
Barcelona
Age
40 years and over
People
60 worldwide
Run by
Stephanie Grasso
See details and how to joinNCT05741853
No phaseTaking people
Trial-Ready Cohort-Down Syndrome (TRC-DS)
Where
Barcelona
Age
25 years to 55 years
People
550 worldwide
Run by
University of Southern California
See details and how to joinNCT04165109
Phase 4Taking people
Characterization of cerebral amyloid deposition with 18F-Flutemetamol PET and of glucose metabolism with 18F-FDG PET in individuals enrolled in the ALFA project
Where
Barcelona
Age
18 years and over
People
400
Run by
Barcelonabeta Brain Research Center
See details and how to join2024-519961-23-00 · EU 2024-519961-23-00
No phaseEnrolling by invitation
Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychiatric Symptoms in Neurodegenerative Diseases and Mental Disorders
Where
Barcelona
Age
18 years and over
People
1,310
Run by
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
See details and how to joinNCT07239843
No phaseTaking people
Long Term Effect of Brain Stimulation in PPA
Where
Madrid
Age
18 years and over
People
80
Run by
Hospital San Carlos, Madrid
See details and how to joinNCT07158216
No phaseNot yet taking people in Spain
Acoustic Stimulation During Sleep: Effects on Memory and p-tau217 in MCI
Where
Lleida
Age
60 years and over
People
114
Run by
Institut de Recerca Biomèdica de Lleida-Fundació Dr. Pifarré (IRBLleida)
See details and how to joinNCT07529015
No phaseNot yet taking people in Spain
DIV-AD BARCELONA: Alzheimer's Blood-Based Biomakers for a Diverse Community
Where
Barcelona
Age
50 years to 75 years
People
250
Run by
Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
See details and how to joinNCT07521722
Phase 2Taking people
Characterization of cerebral tau aggregates with 18F-RO6958948 PET in the ALFA population
Where
Barcelona
Age
18 years and over
People
200
Run by
Barcelonabeta Brain Research Center
See details and how to joinNCT04482660 · EU 2024-516209-21-00
No phaseEnrolling by invitation
Retrospective Observational Study of Blood-based Biomarkers in the Diagnosis and Monitoring of Patients With a Neurodegenerative Disease or Mental Disorder
Where
Barcelona
Age
18 years and over
People
1,799
Run by
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
See details and how to joinNCT07314190
No phaseNot yet taking people in Spain
Effectiveness of Genistein in Mild Cognitive Impairment
Where
Murcia
Age
50 years and over
People
150
Run by
Universidad Católica San Antonio de Murcia
See details and how to joinNCT07385937
Phase 2Taking people
Open-label Extension Study in Participants With Early Alzheimer's Disease
Where
Barcelona
Age
50 years to 85 years
People
220 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07105709
No phaseTaking people
Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles.
Where
Seville
Age
35 years to 36 years
People
8
Run by
University of Seville
See details and how to joinNCT07361887
Phase 3Taking people
LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome
Where
Barcelona, Donostia, Granada, Madrid, Santander
Age
40 years and over
People
120
Run by
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
See details and how to joinNCT07234695 · EU 2024-516148-24-00
Phase 3Not yet taking people in Spain
Tributyrin Treatment in Mild Alzheimer Disease: Assessment of Butyrate Effects Via the Gut-Brain
Where
Almería
Age
18 years and over
People
156
Run by
Universidad de Almeria
See details and how to joinNCT06797817