Alzheimer disease trials in United States

In United States 359 Also abroad 815

359 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
Where
Bethesda
Age
18 years to 99 years
People
184
Run by
National Institute of Mental Health (NIMH)
See details and how to joinNCT04396873
Phase 2Enrolling by invitation
Tau PET Outcomes With Anti-amyloid Immunotherapies
Where
Rochester
Age
50 years to 90 years
People
135
Run by
Mayo Clinic
See details and how to joinNCT06723015
Phase 1Taking people
The Gut - PRO Study
Where
Madison
Age
60 years and over
People
40
Run by
University of Wisconsin, Madison
See details and how to joinNCT07413744
Phase 1Taking people
A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
Where
Charlestown, Decatur, Durham, Maitland, The Villages, Toms River
Age
50 years to 85 years
People
56 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06297590 · EU 2024-510604-37-00
Phase 1Taking people
An Open Label Dose Escalation Study of VY1706 in Participants With Early Alzheimer's Disease
Where
Maitland, Orlando
Age
30 years to 80 years
People
18
Run by
Voyager Therapeutics
See details and how to joinNCT07764146
No phaseNot yet taking people in United States
ALDH2 Genetic Testing in East Asian Community
Where
Chicago
Age
18 years and over
People
100
Run by
Northwestern University
See details and how to joinNCT07392775
No phaseEnrolling by invitation
Fareon Open Label Device Clinical Trial
Where
New York
Age
16 years and over
People
30
Run by
Icahn School of Medicine at Mount Sinai
See details and how to joinNCT07600320
Phase 3Taking people
A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).
Where
Austin, Aventura, Beaumont, Bellevue, Boise, Bolivar, Bradenton, Chicago, Clermont, Dayton, Daytona Beach, Gainesville, Greenacres City, Houston, Huntington Beach, Indianapolis, Irvine, Jacksonville, Lady Lake, Lake Charles, Las Vegas, Lima, Long Beach, Maitland, Merritt Island, Miami, Miami Lakes, Monroe, Mt. Dora, New Port Richey, Newton, Orlando, Pensacola, Phoenix, Port Orange, Riverside, Sacramento, San Diego, Santa Ana, Santa Rosa, Shavano Park, Southfield, Springfield, Tacoma, Tampa, The Villages, Walnut Creek, Waltham, Waterloo, Winter Park, Woodstock
Age
55 years and over
People
550 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07602582
No phaseTaking people
Evaluation of a Decision-Support Tool for Blood Biomarker Testing for Alzheimer's Disease in Primary Care
Where
Madison
Age
50 years and over
People
70
Run by
University of Wisconsin, Madison
See details and how to joinNCT07812337
No phaseNot yet taking people in United States
Negotiation Training for Family Caregivers of People With Alzheimer's Disease
Where
Chicago
Age
21 years and over
People
200
Run by
Northwestern University
See details and how to joinNCT07859540
No phaseTaking people
Combating Alzheimer's Through Sleep and Exercise
Where
Miami
Age
55 years to 80 years
People
60
Run by
University of Miami
See details and how to joinNCT04855630
No phaseTaking people
Triage Survey for Neurology Research Eligibility
Where
Boston, New York, Watertown
Age
18 years and over
People
600
Run by
Adams Clinical
See details and how to joinNCT06104852
Phase 3Taking people
A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
Where
Anaheim, Atlanta, Atlantis, Austin, Bellevue, Belmont, Bloomfield Township, Bonita Springs, Boston, Chandler, Chino, Cleveland, Columbia, Columbus, Cutler Bay, Dallas, Dayton, Daytona Beach, Deerfield Beach, DeSoto, Doral, El Paso, Farmington, Flowood, Fort Worth, Gilbert, Greensboro, Gulf Breeze, Hialeah, Homestead, Houston, Independence, Irving, Kirkland, Lady Lake, Long Beach, Los Angeles, Matthews, Miami, Miami Gardens, Miami Lakes, Morehead City, Naples, Nashville, New Windsor, North Dartmouth, Ocoee, Oklahoma City, Orange, Orlando, Ormond Beach, Pasadena, Phoenix, Plano, Port Orange, Providence, Rancho Cucamonga, Salem, San Antonio, Scottsdale, Shelby, South Dartmouth, Springfield, Stafford, St Louis, Sweetwater, Syracuse, Tampa, The Villages, Toms River, Vienna, Wellington, West Palm Beach, Woodmere
Age
55 years to 90 years
People
406 worldwide
Run by
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
See details and how to joinNCT06585787 · EU 2024-516363-92-00
Phase 3Taking people
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
Where
Abington, Atlantis, Aventura, Basalt, Beaumont, Chicago, Columbus, Cordova, Dayton, East Providence, Elk Grove Village, Gainesville, Long Beach, Matthews, Merritt Island, Newton, New York, Ocala, Portland, Redlands, Saint Paul, Stuart, Syracuse, The Villages, Toms River, Washington D.C.
Age
60 years to 85 years
People
586 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06976216 · EU 2025-520746-30-00
No phaseTaking people
The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study
Where
New York, Pittsburgh, Tucson
Age
55 years to 85 years
People
200
Run by
California Pacific Medical Center Research Institute
See details and how to joinNCT05988385
Phase 2Taking people
Alzheimer's Tau Platform: Master Protocol
Where
Boston, Lexington, Nashville, Phoenix, Providence, San Francisco, Seattle
Age
50 years to 80 years
People
900
Run by
Paul S. Aisen
See details and how to joinNCT06957418
Phase 2Enrolling by invitation
Alzheimer's Tau Platform: Regimen A - AADvac1
Where
Boston, Lexington, Nashville, Phoenix, Providence, San Francisco, Seattle
Age
50 years to 80 years
People
450
Run by
Paul S. Aisen
See details and how to joinNCT07167966
No phaseNot yet taking people in United States
VICA: A Virtual Care Assistant for Dementia Caregivers
Where
Indianapolis
Age
21 years and over
People
120
Run by
Indiana University
See details and how to joinNCT07779785
Phase 3Taking people
[18F]PI-2620 Phase 3 Histopathological Study
Where
Beachwood, Braintree, Centerville, Charlotte, Dallas, East Syracuse, Hialeah, Jacksonville, Kerrville, Lady Lake, Lebanon, Lincoln, Los Angeles, Maitland, Melbourne, Miami, Murrieta, Phoenix, Plymouth, Round Rock, San Francisco, Sarasota, Sun City, Syracuse, Winter Park
Age
50 years and over
People
200
Run by
Lantheus Biosciences Ltd.
See details and how to joinNCT05641688
Phase 1Taking people
A Study of LY4405094 in Healthy Participants and Participants With Alzheimer's Disease
Where
Anaheim, Daytona Beach, Decatur, Farmington Hills, Irvine, Lady Lake, Los Alamitos, Maitland, Orlando, Port Orange, Stuart, Tampa, The Villages
Age
18 years to 85 years
People
68 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07787182 · EU 2026-527295-81-00
No phaseTaking people
Choose Myself (Before) Losing Myself
Where
Cleveland
Age
18 years and over
People
25
Run by
The Cleveland Clinic
See details and how to joinNCT07846566
Phase 1Taking people
A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD
Where
Indianapolis, La Jolla
Age
18 years and over
People
60 worldwide
Run by
Alnylam Pharmaceuticals
See details and how to joinNCT05231785 · EU 2023-508363-79-00
No phaseTaking people
Personalized Obstructive Sleep Apnea Treatment and Effects on Alzheimer's Disease Biomarkers and Cognition Among Blacks
Where
Miami
Age
55 years to 85 years
People
330
Run by
University of Miami
See details and how to joinNCT06089161
Phase 2Taking people
A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
Where
Albany, Atlantis, Beaumont, Chesterfield, Cypress, Decatur, Elk Grove Village, Fort Myers, Independence, Irvine, Long Beach, Los Angeles, Maitland, Marlton, Matthews, Melbourne, Miami Lakes, Naples, New Haven, New Port Richey, Newton, New Windsor, North Canton, Ocala, Orlando, Plymouth Meeting, Queens, Redlands, Ridgewood, San Francisco, Santa Ana, Springfield, Tampa, The Villages, Winter Park
Age
50 years to 85 years
People
340 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07033494 · EU 2024-519190-19-00
No phaseNot yet taking people in United States
SmartEnLite for Nursing Home Residents With Dementia
Where
University Park
Age
55 years and over
People
300
Run by
Penn State University
See details and how to joinNCT07883291