Colorectal cancer trials in Canada

In Canada 89 Also abroad 1942

89 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
Where
Montreal, Toronto
Age
18 years and over
People
473 worldwide
Run by
Bicara Therapeutics
See details and how to joinNCT04429542
No phaseTaking people
Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
Where
Calgary, London, Vancouver, Winnipeg
Age
65 years to 82 years
People
6,434 worldwide
Run by
Dartmouth-Hitchcock Medical Center
See details and how to joinNCT05612347
Phase 1Taking people
In Vivo Lung Perfusion (IVLP) for Colorectal Cancer Metastatic to Lung
Where
Toronto
Age
18 years to 70 years
People
10
Run by
University Health Network, Toronto
See details and how to joinNCT05611034
No phaseTaking people
Liquid Biopsy Evaluation and Repository Development at Princess Margaret
Where
Toronto
Age
18 years and over
People
2,500
Run by
University Health Network, Toronto
See details and how to joinNCT03702309
Phase 1Taking people
A Study of GSK5764227 in Combination With Standard of Care (SoC) or Other Agents in Participants With Advanced Solid Tumors
Where
Ottawa, Toronto
Age
18 years and over
People
83 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07277270 · EU 2025-522274-37-00
No phaseTaking people
Virtual Rehabilitation for Cancer Survivors
Where
Toronto
Age
18 years and over
People
388
Run by
University Health Network, Toronto
See details and how to joinNCT05898789
Phase 2Taking people
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
Where
Montreal, Québec, Toronto
Age
18 years to 130 years
People
454 worldwide
Run by
AstraZeneca
See details and how to joinNCT05489211 · EU 2023-509436-26-00
No phaseTaking people
Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps
Where
Montreal
Age
18 years and over
People
892
Run by
Centre hospitalier de l'Université de Montréal (CHUM)
See details and how to joinNCT06271941
Phase 1/2Taking people
A Study to Investigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors
Where
Hamilton, Montreal, Toronto
Age
18 years and over
People
47 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT07213609
No phaseTaking people
Complete Closure After Endoscopic Mucosal Resection of Large Non-Pedunculated Colorectal Polyps
Where
Montreal
Age
18 years and over
People
686
Run by
Centre hospitalier de l'Université de Montréal (CHUM)
See details and how to joinNCT06807073
Phase 3Taking people
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Where
Brampton, Calgary, Regina, Saskatoon, Toronto
Age
18 years and over
People
450 worldwide
Run by
Amgen
See details and how to joinNCT06252649
Phase 4Taking people
TES RCT Fleet Enema vs Oral Mechanical Bowel Prep
Where
Halifax
Age
18 years to 75 years
People
66
Run by
Nova Scotia Health Authority
See details and how to joinNCT05148494
Phase 1/2Taking people
A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
Where
Edmonton, Hamilton, Montreal, Ottawa, Toronto, Vancouver
Age
18 years and over
People
1,109 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT04895709
No phaseNot yet taking people in Canada
Reducing Neoplasia Recurrence After Non-thermal Endoscopic Resection of Large Colorectal Polyps
Where
Montreal
Age
18 years and over
People
752
Run by
Centre hospitalier de l'Université de Montréal (CHUM)
See details and how to joinNCT07242820
Phase 2Taking people
Hepatic Arterial Infusion Chemotherapy in Patients With Inoperable Colorectal Cancer Liver Metastasis
Where
Toronto
Age
18 years and over
People
200
Run by
Sunnybrook Health Sciences Centre
See details and how to joinNCT07764497
No phaseTaking people
Advanced Endo-therapeutic Procedure : Registry-based Observational Study
Where
Montreal
Age
18 years and over
People
500
Run by
Centre hospitalier de l'Université de Montréal (CHUM)
See details and how to joinNCT04117100
Phase 1/2Taking people
A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
Where
Toronto
Age
18 years and over
People
366 worldwide
Run by
Marengo Therapeutics, Inc.
See details and how to joinNCT05592626 · EU 2023-505334-10-01
Phase 1Taking people
AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors
Where
Edmonton, Montreal, Toronto
Age
18 years and over
People
434 worldwide
Run by
Amgen
See details and how to joinNCT07094113
Phase 1Taking people
Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers
Where
Montreal, Toronto
Age
18 years to 100 years
People
162 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06562192
Phase 1Taking people
A Study of BMS-986488 as Monotherapy and Combination Therapy in Participants With Advanced Malignant Tumors
Where
Montreal, Québec, Vancouver
Age
18 years and over
People
437 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06764771
Phase 3Taking people
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Where
Montreal, Ottawa, Saskatoon, Toronto
Age
18 years and over
People
400 worldwide
Run by
Seagen, a wholly owned subsidiary of Pfizer
See details and how to joinNCT05253651 · EU 2024-514180-25-00
Phase 1Taking people
A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
Where
Montreal, Ottawa, Toronto
Age
18 years and over
People
914 worldwide
Run by
Seagen, a wholly owned subsidiary of Pfizer
See details and how to joinNCT06131840 · EU 2023-505858-18-00
Phase 1Taking people
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
Where
Ottawa, Toronto
Age
18 years and over
People
710 worldwide
Run by
Incyte Corporation
See details and how to joinNCT06179160 · EU 2023-507091-47-00
Phase 2Taking people
A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer
Where
Montreal, Ottawa, Toronto
Age
18 years and over
People
144 worldwide
Run by
Ono Pharmaceutical Co., Ltd.
See details and how to joinNCT06948448
Phase 2Taking people
Safely Optimizing Body Weight With Mifomelatide (TCMCB07) in Patients With Newly Diagnosed Colorectal Cancer (CRC) or Pancreatic Ductal Adenocarcinoma (PDAC) Undergoing Chemotherapy
Where
Edmonton
Age
18 years and over
People
120 worldwide
Run by
Endevica Bio
See details and how to joinNCT06937177