Dermatomyositis and polymyositis (myositis) trials in United States

In United States 45 Also abroad 124

45 trials · From ClinicalTrials.gov, checked 13 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
Where
Atlanta, Baltimore, Bethesda, Birmingham, Boston, Chicago, City of Saint Peters, Columbus, Creve Coeur, Dallas, Detroit, Fairway, Fort Worth, Hays, Houston, Kansas City, Lawrence, Lee's Summit, Lexington, Mineola, New Brunswick, New Haven, New York, North Kansas City, Olathe, Overland Park, Palo Alto, Philadelphia, Pittsburg, Pittsburgh, Richardson, Richmond, Sacramento, Salina, Salt Lake City, St Louis, Topeka, Washington D.C., Westwood
Age
18 years and over
People
300 worldwide
Run by
National Cancer Institute (NCI)
See details and how to joinNCT03816345
Phase 2Taking people
FAST for DM - Fatty Acid Supplementation Trial (FAST) for Dermatomyositis (DM)
Where
Bethesda
Age
18 years to 62 years
People
3,000
Run by
National Institute of Environmental Health Sciences (NIEHS)
See details and how to joinNCT07111065
Phase 1/2Taking people
A Study of AZD0120 in Autoimmune Diseases
Where
Ann Arbor, Baltimore, Chapel Hill, Chicago, Duarte, Miami, New York, Seattle, Stanford, St Louis, Tucson
Age
18 years to 75 years
People
27 worldwide
Run by
AstraZeneca
See details and how to joinNCT07295847
No phaseTaking people
Natural History of Inflammatory Muscle Diseases
Where
Bethesda
Age
2 years to 120 years
People
500
Run by
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
See details and how to joinNCT05738824
Phase 1Taking people
A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease
Where
Aurora, Baltimore, Charleston, Charlotte, Chicago, Durham, East Brunswick, Greenville, Iowa City, Jacksonville, Kansas City, Loma Linda, Louisville, New York, Phoenix, Salt Lake City, Valhalla
Age
18 years to 74 years
People
66 worldwide
Run by
Allogene Therapeutics
See details and how to joinNCT07085104
Phase 1/2Taking people
A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2)
Where
Ann Arbor, Charlotte, Dallas, Fairway, Hackensack, Los Angeles, Minneapolis, New York, Plantation, Summit, Syracuse, Tampa
Age
18 years to 75 years
People
240
Run by
Nkarta, Inc.
See details and how to joinNCT06733935
Phase 3Not yet taking people in United States
A Study to Understand How Nerandomilast Works in People With Active Idiopathic Inflammatory Myopathies
Where
Ann Arbor, Aurora, Baltimore, Boston, Cleveland, Dallas, Fairway, Great Neck, Houston, Irvine, Jackson, Los Angeles, Middleburg Heights, Philadelphia, Phoenix, Pittsburgh, Portland, Rochester, San Francisco, Scottsdale, St Louis
Age
18 years and over
People
270 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT07789015 · EU 2026-526365-24-00
Phase 2Taking people
Topical Ruxolitinib Cream for Refractory Cutaneous Dermatomyositis
Where
Cleveland
Age
18 years to 89 years
People
15
Run by
The Cleveland Clinic
See details and how to joinNCT06857240
No phaseTaking people
Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis
Where
Baltimore
Age
18 years and over
People
30
Run by
Johns Hopkins University
See details and how to joinNCT07823101
Phase 1Taking people
A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease
Where
Boston, Chapel Hill, Chicago, Iowa City, La Jolla, New Orleans, Portland, Redwood City, St Louis
Age
18 years to 70 years
People
80 worldwide
Run by
CRISPR Therapeutics
See details and how to joinNCT06925542
Phase 1Taking people
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
Where
Anniston, Birmingham, Chapel Hill, Iowa City, La Jolla, Omaha, Sacramento
Age
18 years to 70 years
People
72 worldwide
Run by
AstraZeneca
See details and how to joinNCT06916806 · EU 2024-519015-34-00
No phaseTaking people
Environmental Risk Factors for the Anti-synthetase Syndrome
Where
Baltimore, Bethesda, Boston, Miami, Pittsburgh, Research Triangle Park, Rochester, Rockville
Age
2 years to 100 years
People
580
Run by
National Institute of Environmental Health Sciences (NIEHS)
See details and how to joinNCT01276470
Phase 3Enrolling by invitation
A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy
Where
Atlanta, Austin, Baltimore, Beverly Hills, Chapel Hill, Chicago, Columbus, Gainesville, Great Neck, Houston, Jacksonville, New Haven, Orange, Phoenix, Pittsburgh, Portland, San Francisco, Tampa
Age
18 years and over
People
240 worldwide
Run by
argenx
See details and how to joinNCT05979441 · EU 2022-502851-79-00
Phase 2/3Taking people
RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy
Where
Ann Arbor, Atlanta, Aurora, Bethesda, Boston, Chapel Hill, Chicago, Dallas, Durham, Houston, Jacksonville, Kansas City, Milwaukee, Nashville, New York, Orange, Philadelphia, Pittsburgh, Portland, Rochester, Salt Lake City, San Francisco, Seattle, St. Petersburg, The Bronx
Age
6 years to 75 years
People
74 worldwide
Run by
Cabaletta Bio
See details and how to joinNCT06154252 · EU 2025-521145-24-01
Phase 1Not yet taking people in United States
A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases
Where
Ann Arbor, Great Neck, Morristown, Newport Beach, Omaha, Philadelphia, Saint Paul, Salt Lake City, Seattle, Worcester
Age
18 years and over
People
60 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT07873931
No phaseEnrolling by invitation
Comparative Autoantibody and Immunologic Cell Marker Study
Where
Atlanta
Age
18 years and over
People
2,500
Run by
Emory University
See details and how to joinNCT02422875
Phase 1Enrolling by invitation
A Study of KITE-363 in Participants With Refractory Autoimmune Diseases
Where
Duarte, New York, Stanford, Tampa
Age
18 years and over
People
52 worldwide
Run by
Kite, A Gilead Company
See details and how to joinNCT07038447
No phaseTaking people
Adult and Juvenile Myositis
Where
Atlanta, Bethesda, Dallas, Research Triangle Park
Age
2 years to 100 years
People
1,200
Run by
National Institute of Environmental Health Sciences (NIEHS)
See details and how to joinNCT00017914
Phase 3Taking people
A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)
Where
Allen, Amarillo, Ann Arbor, Atlanta, Aurora, Austin, Baltimore, Beckley, Boca Raton, Boston, Boynton Beach, Charleston, Charlotte, Cleveland, Colleyville, Denver, Durham, El Paso, Fairway, Gainesville, Galveston, Great Neck, Harlingen, Houston, Irvine, Margate, Miami, Middleburg Heights, Milwaukee, New Haven, North Richland Hills, Orlando, Palm Beach Gardens, Philadelphia, Phoenix, Pittsburgh, Plant City, Sterling Heights, Summerville, Washington D.C., Willowbrook
Age
18 years to 75 years
People
240 worldwide
Run by
AstraZeneca
See details and how to joinNCT06455449
Phase 2Taking people
Ublituximab in Autoantibody Positive Immune Mediated Necrotizing Myopathy
Where
Atlanta, Baltimore, Birmingham, Chicago, Great Neck, Houston, Pittsburgh, Rochester
Age
18 years and over
People
30
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
See details and how to joinNCT07103746
Phase 3Taking people
A Study to Understand How the Study Medicine (PF-06823859) Works in People With Active Idiopathic Inflammatory Myopathies [Dermatomyositis (DM) and Polymyositis (PM)]
Where
Beckley, Boston, Cleveland, Edinburg, Frisco, Glendale, Harlingen, Houston, Jacksonville, Katy, Los Angeles, Margate, Miami, New York, Oklahoma City, Orange, Orlando, Phoenix, Pittsburgh, Plantation, Rancho Mirage, Scottsdale, St Louis, Tamarac, Weslaco
Age
18 years and over
People
318 worldwide
Run by
Pfizer
See details and how to joinNCT05895786 · EU 2022-502739-20-00
Phase 1/2Taking people
FT839 in Autoimmune Diseases
Where
Fullerton
Age
18 years to 70 years
People
446
Run by
Fate Therapeutics
See details and how to joinNCT07800871
Phase 3Taking people
A Study to Understand How the Study Medicine Dazukibart Works in People With Idiopathic Inflammatory Myopathies
Where
Beckley, Frisco, Glendale, Houston
Age
18 years and over
People
211 worldwide
Run by
Pfizer
See details and how to joinNCT06698796 · EU 2024-514648-10-00
Phase 2Taking people
Emapalumab MDA5 Rapidly Progressive Interstitial Lung Disease (RP-ILD) Study
Where
Miami
Age
18 years and over
People
5
Run by
University of Miami
See details and how to joinNCT07486869
Phase 2Taking people
Descartes-08 in Autoantibody Myositis
Where
Austin, Boston, Chapel Hill, Orange
Age
18 years and over
People
60
Run by
Cartesian Therapeutics
See details and how to joinNCT07391605