Diffuse large B-cell lymphoma trials in United States

In United States 131 Also abroad 346

131 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Early phase 1Taking people
A Study of Daratumumab and Dose-Adjusted EPOCH in Plasmablastic Lymphoma
Where
Baltimore, Chapel Hill, Chicago, Columbus, Houston, Miami, New York, Philadelphia, Salt Lake City
Age
18 years and over
People
15
Run by
AIDS Malignancy Consortium
See details and how to joinNCT04139304
Phase 2Taking people
Study Adding Drugs to Usual Treatment for Large B-Cell Lymphoma That Returned or Did Not Respond to Treatment
Where
Ankeny, Ann Arbor, Appleton, Ashland, Beverly Hills, Brighton, Burlington, Canton, Cedar Rapids, Charleston, Chelsea, Chicago, City of Saint Peters, Clive, Creve Coeur, Crown Point, Danville, Deer River, Des Moines, Duarte, Duluth, Dyer, Eau Claire, Effingham, Flint, Fort Lauderdale, Germantown, Grafton, Green Bay, Hibbing, Hobart, Houston, Huntington Beach, Indianapolis, Jackson, Kenosha, La Crosse, Lancaster, Lansing, Livonia, Long Beach, Los Angeles, Marinette, Marshfield, Mattoon, Miami Beach, Milwaukee, Minocqua, Munster, Newberg, New Lenox, Newport Beach, New York, Oklahoma City, Oregon City, Orland Park, Oshkosh, Pontiac, Portland, Racine, Rice Lake, Richmond, Rochester, Salt Lake City, San Antonio, Sandstone, Sheboygan, Shiloh, South Pasadena, Stevens Point, St Louis, Summit, Torrance, Tucson, Two Rivers, Upland, Urbana, Valparaiso, Virginia, Wauwatosa, Webster, West Allis, Weston, Ypsilanti
Age
18 years and over
People
227
Run by
SWOG Cancer Research Network
See details and how to joinNCT05890352
Phase 1Taking people
Anti-CD19 Chimeric Antigen Receptor T Cells for Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma
Where
San Francisco
Age
18 years and over
People
36
Run by
C. Babis Andreadis
See details and how to joinNCT04545762
Phase 1Taking people
Testing the Combination of Anti-cancer Drugs Mosunetuzumab, Polatuzumab Vedotin, and Lenalidomide for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Where
Charlottesville, Chicago, Cleveland, Duarte, Oklahoma City, Sacramento, Tampa, Winston-Salem
Age
18 years and over
People
30
Run by
National Cancer Institute (NCI)
See details and how to joinNCT06015880
Phase 1/2Taking people
Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)
Where
Chapel Hill, Columbus, Denver, Duarte, Houston, Jacksonville, Los Angeles, Nashville, Portland, Rochester, Valhalla
Age
13 years to 90 years
People
32
Run by
Vironexis Biotherapeutics Inc.
See details and how to joinNCT06533579
Phase 1Taking people
Low-Dose TBI Plus CAR T-Cell Therapy for Relapsed/Refractory DLBCL and Multiple Myeloma
Where
New York
Age
18 years and over
People
32
Run by
Weill Medical College of Cornell University
See details and how to joinNCT07725406
Phase 2Taking people
Obinutuzumab and ICE Chemotherapy in Refractory/Recurrent CD20+ Mature NHL
Where
Valhalla
Age
3 years to 31 years
People
25
Run by
New York Medical College
See details and how to joinNCT02393157
Phase 2Taking people
Natalizumab for the Prevention of ICANS in Patients With Recurrent or Refractory Diffuse Large B-Cell Lymphoma or Mantle Cell Lymphoma Receiving CAR T-Cell Therapy
Where
Ann Arbor
Age
18 years and over
People
26
Run by
University of Michigan Rogel Cancer Center
See details and how to joinNCT07892027
Phase 2Taking people
Epcoritamab With Dose Adjusted Etoposide, Cyclophosphamide, Vincristine, Doxorubicin, Prednisone and Rituximab (EPOCH-R) for the Treatment of Aggressive B-Cell Non-Hodgkin Lymphoma
Where
Seattle
Age
18 years and over
People
18
Run by
University of Washington
See details and how to joinNCT07097363
Phase 2Taking people
Golcadomide and Rituximab as Bridging Therapy for Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphoma Before CAR T-cell Therapy
Where
Albert Lea, Eau Claire, Jacksonville, La Crosse, Mankato, Rochester, Scottsdale
Age
18 years and over
People
41
Run by
Mayo Clinic
See details and how to joinNCT06834373
Phase 1Not yet taking people in United States
Axatilimab + CAR-T for High-Risk Lymphoma
Where
Atlanta
Age
8 years and over
People
29
Run by
Northside Hospital, Inc.
See details and how to joinNCT07638982
Phase 1Taking people
A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma
Where
Anaheim, Austin, Boston, Dallas, Duarte, Fairfax, Fairway, Hackensack, Irving, Kansas City, Louisville, Myrtle Beach, Nashville, Newton, Norwalk, Oklahoma City, Omaha, Overland Park, Port Angeles, Poulsbo, Rockville, San Antonio, Seattle, Tucson, Westwood
Age
18 years and over
People
453 worldwide
Run by
Pfizer
See details and how to joinNCT03460977 · EU 2023-509179-18-00
Phase 2Taking people
Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma
Where
Albuquerque, Atlanta, Baltimore, Baton Rouge, Battle Creek, Boiling Springs, Boise, Burlington, Charleston, Charlotte, Chicago, Cleveland, Clinton Township, Concord, Costa Mesa, Danville, Dearborn, Detroit, Durham, Easley, Fargo, Farmington Hills, Fayetteville, Fruitland, Gainesville, Grand Rapids, Greenville, Greer, Iowa City, Irvine, Jackson, Kalamazoo, Kansas City, Laguna Hills, Lebanon, Little Rock, Louisville, Madison, Maywood, Memphis, Meridian, Milwaukee, Muskegon, Nampa, Newberg, New Berlin, New York, Niles, Norton Shores, Novi, Oklahoma City, Orange, Oregon City, Overland Park, Philadelphia, Portland, Reed City, Richmond, Rochester, Rogers, Saint Johnsbury, Saint Joseph, San Francisco, Seattle, Seneca, Southfield, Springdale, Traverse City, Tucson, Twin Falls, Webster, West Bloomfield, Westwood, Wilkes-Barre, Winston-Salem, Wyandotte, Wyoming
Age
18 years and over
People
396
Run by
SWOG Cancer Research Network
See details and how to joinNCT05633615
Phase 2Taking people
Epcoritamab in Combination With Loncastuximab Tesirine in Relapsed/Refractory Large B-cell Lymphoma
Where
Miami
Age
18 years and over
People
26
Run by
University of Miami
See details and how to joinNCT06919939
Phase 1Taking people
A Study of APG-3288 in Relapsed/Refractory Blood Cancers
Where
East Brunswick, Grand Rapids, Houston, Jacksonville, Los Angeles
Age
18 years and over
People
180 worldwide
Run by
Ascentage Pharma Group Inc.
See details and how to joinNCT07424833
Phase 2Not yet taking people in United States
Prizloncabtagene Autoleucel (Prizlon-cel) for the Treatment of Relapsed or Refractory Large B-cell Lymphoma Post FDA Approved CAR T-cell Therapy
Where
Gilbert, La Jolla
Age
18 years and over
People
55
Run by
AbelZeta Inc.
See details and how to joinNCT07875413
Phase 2Taking people
A Study of PET Adapted Therapy and Non-invasive Monitoring for Previously Untreated Limited Stage Diffuse Large B Cell Lymphoma
Where
Rochester
Age
18 years and over
People
40
Run by
University of Rochester
See details and how to joinNCT03758989
No phaseTaking people
Study of a Communication Training Intervention for Large B-Cell Lymphoma Providers
Where
New York
Age
18 years and over
People
48
Run by
Memorial Sloan Kettering Cancer Center
See details and how to joinNCT05940272
Phase 3Taking people
Adding Pirtobrutinib to the Usual Treatment for People With Newly Diagnosed Richter Transformation, The PIRAMID Trial
Where
Baton Rouge, Bellevue, Bloomington, Brighton, Canton, Carthage, Chapel Hill, Chelsea, City of Saint Peters, Creve Coeur, Danville, Decatur, Durham, Effingham, Eureka, Galesburg, Irvine, Kewanee, Kirkland, Laguna Hills, Livonia, Macomb, Mattoon, Menomonee Falls, Milwaukee, Mukwonago, New Berlin, Normal, Oak Creek, Oconomowoc, O'Fallon, Orange, Ottawa, Pekin, Peoria, Peru, Philadelphia, Pontiac, Princeton, Richmond, Salt Lake City, Seattle, Shiloh, Springfield, St Louis, Urbana, Washington, Waukesha, West Bend, Ypsilanti
Age
18 years and over
People
102
Run by
SWOG Cancer Research Network
See details and how to joinNCT07220187
Phase 1Taking people
CD79b-19 CAR T Cells in Non-Hodgkin Lymphoma
Where
Boston
Age
18 years and over
People
24
Run by
Marcela V. Maus, M.D.,Ph.D.
See details and how to joinNCT06026319
Phase 1Taking people
A Study to Evaluate INCA036873 in Participants With Advanced Solid Tumors and Hematological Malignancies
Where
Ann Arbor, Duarte, Houston, La Jolla, Nashville, New York, Omaha
Age
18 years and over
People
280 worldwide
Run by
Incyte Corporation
See details and how to joinNCT07195916 · EU 2025-523130-11-00
Phase 1Taking people
Lymphodepletion With Low Dose Total Body Irradiation Before Standard of Care Tisagenlecleucel for the Treatment of Relapsed and Recurrent Large B-cell Lymphoma
Where
Columbus
Age
18 years and over
People
18
Run by
Nathan Denlinger
See details and how to joinNCT07676877
Phase 2Taking people
Loncastuximab Tesirine and Mosunetuzumab for the Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Where
Duarte
Age
18 years and over
People
36
Run by
City of Hope Medical Center
See details and how to joinNCT05672251
Phase 2Taking people
Emapalumab Prevention of CAR-T Cell Associated Toxicities
Where
Boston
Age
18 years and over
People
28
Run by
Marcela V. Maus, M.D.,Ph.D.
See details and how to joinNCT06550141
Phase 1/2Taking people
A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies
Where
Augusta, Baton Rouge, Bethesda, Birmingham, Boston, Buffalo, Chattanooga, Detroit, Fort Collins, Houston, Iowa City, Jacksonville, La Jolla, Las Vegas, Louisville, Miami, Nashville, Newnan, New York, Palo Alto, Phoenix, Richmond, Rochester, Santa Monica, Scottsdale, Seattle, Tampa, Tucson, Zion
Age
18 years and over
People
689 worldwide
Run by
BeOne Medicines
See details and how to joinNCT05006716 · EU 2022-502157-33-00