Diffuse large B-cell lymphoma trials in United States

In United States 131 Also abroad 346

131 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
Constitutive IL7R (C7R) Modified Banked Allogeneic CD30.CAR EBVSTS for CD30-Positive Lymphomas
Where
Houston
Age
12 years to 75 years
People
90
Run by
Baylor College of Medicine
See details and how to joinNCT06176690
Phase 2Taking people
Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse Large B-cell Lymphoma Subtype
Where
Buffalo
Age
18 years and over
People
32
Run by
Roswell Park Cancer Institute
See details and how to joinNCT06863402
Phase 2Taking people
Intrathecal Cytarabine and Hydrocortisone for the Early Treatment of ICANS in Patients Undergoing CAR T Therapy for Non Hodgkin Lymphoma
Where
Nashville
Age
18 years and over
People
59
Run by
Vanderbilt-Ingram Cancer Center
See details and how to joinNCT07763210
Phase 2Not yet taking people in United States
Epcoritamab in Combination With R-CHOP for Patients With Aggressive Non-Hodgkin Lymphoma
Where
San Francisco
Age
18 years and over
People
20
Run by
Carrie Ho, MD
See details and how to joinNCT07588698
Phase 1Taking people
Loncastuximab and Roflumilast Added to R-CHOP (Lo-(Rituximab and Roflumilast) RR-CHOP) for Naïve High-Risk Diffuse Large B-cell Lymphoma (DLBCL)
Where
San Antonio
Age
18 years and over
People
10
Run by
The University of Texas Health Science Center at San Antonio
See details and how to joinNCT06977711
Phase 2Taking people
Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia
Where
Eau Claire, La Crosse, Mankato, Rochester
Age
18 years and over
People
80
Run by
Mayo Clinic
See details and how to joinNCT03418038
Phase 2Taking people
Phase 2 Trial of Epcoritamab in Combination With Rituximab-mini CVP for Older Unfit/Frail Patients or Anthracycline-Ineligible Adult Patients With Newly Diagnosed Diffuse Large B-cell Lymphoma
Where
Houston
Age
18 years and over
People
40
Run by
M.D. Anderson Cancer Center
See details and how to joinNCT06045247
Phase 1Taking people
Epcoritamab for the Treatment of Relapsed or Refractory Post Transplant Lymphoproliferative Disorders
Where
Columbus, St Louis
Age
18 years and over
People
26
Run by
Timothy Voorhees
See details and how to joinNCT06672705
No phaseTaking people
Vaccine Responses in Patient With Multiple Myeloma and Non-Hodgkin Lymphoma After CAR-T Treatment
Where
Portland
Age
18 years and over
People
45
Run by
OHSU Knight Cancer Institute
See details and how to joinNCT06784167
Phase 2Taking people
Itacitinib Pre-modulation in DLBCL Receiving CAR T Cell Therapy
Where
Tampa
Age
18 years and over
People
27
Run by
H. Lee Moffitt Cancer Center and Research Institute
See details and how to joinNCT05757219
Phase 1Taking people
Zanubrutinib in Combination With Odronextamab for the Treatment of Patients With Richter's Transformation
Where
Duarte
Age
18 years and over
People
23
Run by
City of Hope Medical Center
See details and how to joinNCT06735664
Phase 1Enrolling by invitation
CD19.20.22 CAR T-cells for Patients With Relapsed/Refractory B-Cell Lymphomas
Where
Baltimore
Age
18 years and over
People
15
Run by
University of Maryland, Baltimore
See details and how to joinNCT07168486
Phase 1Taking people
Testing the Combination of Nivolumab and ASTX727 for Relapsed or Refractory B-Cell Lymphoma
Where
Birmingham, Chicago, Duarte, Mineola, New Haven, New Lenox, New York, Orland Park, Sacramento
Age
18 years and over
People
32
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05272384
Phase 1Taking people
Rituximab (Rtx) + Tafasitamab in Combination With Allogeneic NK Cells for Treatment of Relapsed/Refractory (r/r) B-cell Non-Hodgkin Lymphoma (NHL)
Where
Cleveland
Age
18 years and over
People
15
Run by
Paolo Caimi, MD
See details and how to joinNCT07225439
Phase 1Taking people
A Phase Ib Study of VK-2019 in Patients With Relapsed or Refractory EBV+ Diffuse Large B-cell Lymphomas (DLBCL)
Where
Lexington
Age
18 years and over
People
30
Run by
Pierluigi Porcu
See details and how to joinNCT06789159
Phase 2Not yet taking people in United States
TPG: Tafasitamab, Polatuzumab Vedotin, and Glofitamab as First-line Therapy for Diffuse Large B-cell Lymphoma and High-grade B-cell Lymphoma
Where
Providence
Age
18 years and over
People
30
Run by
Brown University
See details and how to joinNCT07502872
Phase 2Taking people
CNS-Relapse Prevention in High-Risk Diffuse Large B-cell Lymphoma With Thiotepa-based Autologous Stem Cell Transplant
Where
St Louis
Age
18 years to 75 years
People
36
Run by
Washington University School of Medicine
See details and how to joinNCT06687772
Phase 2Taking people
Odronextamab for Relapsed and Refractory Large B-cell Lymphomas Before CAR-T
Where
Seattle
Age
18 years and over
People
27
Run by
University of Washington
See details and how to joinNCT06784726
Phase 2Taking people
Epcoritamab, Rituximab, Gemcitabine and Oxaliplatin (R-GemOx) as Salvage Therapy Before Autologous Stem Cell Transplant for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Where
Duarte, Newnan, Zion
Age
18 years and over
People
43
Run by
City of Hope Medical Center
See details and how to joinNCT07365306
Phase 1Taking people
Pilot Study of Anti-CD19 Chimeric Antigen Receptor T Cells (CAR-T Cells) for the Treatment of Relapsed/Refractory CD19+ Malignancies
Where
Salt Lake City
Age
18 years and over
People
10
Run by
University of Utah
See details and how to joinNCT06227026
Phase 1Taking people
Pomalidomide and Dose-Adjusted EPOCH +/- Rituximab for HIV-Associated Lymphomas
Where
Bethesda
Age
18 years to 120 years
People
25
Run by
National Cancer Institute (NCI)
See details and how to joinNCT05389423
Phase 1/2Taking people
Study of Rondecabtagene Autoleucel in Aggressive Large B-Cell Lymphoma
Where
Albuquerque, Allentown, Augusta, Buffalo, Cincinnati, Cleveland, Dallas, Denver, Grand Rapids, Hackensack, Indianapolis, Iowa City, Irvine, Los Angeles, Louisville, Milwaukee, Nashville, New York, Norfolk, Omaha, Philadelphia, Pittsburgh, Richmond, Salt Lake City, San Antonio, San Diego, Shreveport, The Bronx, Washington D.C., Winston-Salem
Age
18 years and over
People
270 worldwide
Run by
Lyell Immunopharma, Inc.
See details and how to joinNCT05826535
Phase 1/2Taking people
Epcoritamab Plus Ibrutinib for the Treatment of Relapsed or Refractory Aggressive B-Cell Non-Hodgkin Lymphoma
Where
Columbus, Minneapolis, Richmond
Age
18 years and over
People
38
Run by
Yazeed Sawalha
See details and how to joinNCT06536049
Phase 2Taking people
Mosunetuzumab and Polatuzumab Vedotin With Split-Dose CHP Chemotherapy for Elderly Patients With Diffuse Large B-Cell Lymphoma
Where
Milwaukee
Age
70 years and over
People
31
Run by
Medical College of Wisconsin
See details and how to joinNCT06594939
Phase 1/2Taking people
A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas
Where
Ann Arbor, Atlanta, Baltimore, Boston, Buffalo, Charlottesville, Chicago, Cincinnati, Grand Rapids, Hackensack, Maywood, New York, Philadelphia, Rochester, San Antonio, Seattle, Tampa, The Bronx
Age
18 years and over
People
300 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT04104776 · EU 2023-508002-20-00