Epilepsy trials in United States

In United States 208 Also abroad 459

156 of 208 trials · From ClinicalTrials.gov, checked 14 November 2026. Ask the study team whether a trial fits you.

No phaseEnrolling by invitation
Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
Where
Houston
Age
22 years to 70 years
People
84
Run by
Baylor College of Medicine
See details and how to joinNCT05418894
No phaseTaking people
Biomarker Targeted Stimulation for Epileptiform Events
Where
Rochester
Age
7 years and over
People
40
Run by
Cadence Neuroscience
See details and how to joinNCT06424977
Phase 3Taking people
Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1
Where
Asheville, Atlanta, Bethesda, Birmingham, Boise, Cleveland, Fort Wayne, Gulf Breeze, Hackensack, Livingston, New York, Palmdale, Philadelphia, Richmond, San Francisco, Springfield, The Bronx
Age
18 years to 75 years
People
333 worldwide
Run by
Rapport Therapeutics Inc.
See details and how to joinNCT07563881 · EU 2025-524847-11-01
Phase 3Taking people
Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures
Where
Bentonville, Chicago, Colorado Springs, Honolulu, Houston, Huntsville, Maitland, Miami, Nashville, New York, Omaha, Raleigh
Age
18 years to 75 years
People
312 worldwide
Run by
Rapport Therapeutics Inc.
See details and how to joinNCT07594119
Phase 2/3Taking people
A Study to Evaluate the Safety and Efficacy of JZP926 Capsule for the Treatment of Juvenile Myoclonic Epilepsy
Where
Atlanta, Boise, Chicago, Cincinnati, Dallas, Grand Rapids, Hawthorne, Honolulu, Lake Success, Lexington, Los Angeles, New Brunswick, New Haven, New York, Philadelphia, Phoenix, Portland, Roanoke, Sacramento, Savannah, Tampa, Virginia Beach, Winchester
Age
10 years and over
People
260
Run by
Jazz Pharmaceuticals
See details and how to joinNCT07723963
No phaseNot yet taking people in United States
RESTORE: Restoring State-dependent Thalamocortical Oscillations in Epilepsy
Where
Rochester
Age
18 years and over
People
10
Run by
Gregory Worrell
See details and how to joinNCT07927985
Phase 3Taking people
Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults
Where
Austin, Baltimore, Bethesda, Boise, Columbia, Dallas, Durham, Hackensack, Jacksonville, Lexington, New Brunswick, New Orleans, Orlando, Palo Alto, Philadelphia, Rochester, Tampa, The Bronx, Wellington, Winchester, Winston-Salem
Age
4 years to 55 years
People
252 worldwide
Run by
SK Life Science, Inc.
See details and how to joinNCT05219617
No phaseEnrolling by invitation
Neural Mechanisms for Stopping Ongoing Speech Production (Study 2)
Where
Pittsburgh
Age
8 years to 26 years
People
12
Run by
University of Pittsburgh
See details and how to joinNCT07713706
Phase 3Taking people
A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
Where
Akron, Amherst, Ann Arbor, Atlanta, Aurora, Austin, Baltimore, Bethesda, Boise, Boys Town, Charleston, Charlotte, Chestnut Hill, Cleveland, Clinton, Columbus, Detroit, Durham, East Lansing, El Paso, Grand Rapids, Hackensack, Honolulu, Houston, Indianapolis, Jacksonville, Kansas City, Lexington, Little Rock, Los Angeles, Miami, Milwaukee, Mobile, Orange, Orlando, Pensacola, Philadelphia, Phoenix, Pittsburgh, Port Charlotte, Sacramento, Salt Lake City, San Antonio, Seattle, Springfield, St Louis, Suwanee, Syracuse, Tampa, Tucson, Virginia Beach, Weston, Winston-Salem, Woodmere, Worcester
Age
12 years and over
People
160 worldwide
Run by
Xenon Pharmaceuticals Inc.
See details and how to joinNCT05667142 · EU 2022-502286-16-00
Phase 3Taking people
A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)
Where
Austin, Bethesda, Boise, Cleveland, Columbus, Detroit, Downey, Durham, Gulf Breeze, Hackensack, Jacksonville, Little Rock, Los Angeles, Nashville, Orange, Portland, Salt Lake City, Springfield, Woodmere
Age
18 years and over
People
360 worldwide
Run by
Xenon Pharmaceuticals Inc.
See details and how to joinNCT05716100 · EU 2022-502281-25-00
Phase 3Enrolling by invitation
An Open-label Study of XEN1101 in Epilepsy
Where
Akron, Ann Arbor, Aurora, Austin, Baltimore, Bethesda, Boise, Boston, Buffalo, Burnsville, Charlotte, Cleveland, Columbus, Detroit, Durham, East Lansing, El Paso, Grand Rapids, Hackensack, Honolulu, Indianapolis, Jacksonville, Kansas City, Lexington, Little Rock, Los Angeles, Miami, Milwaukee, Nashville, New York, Orange, Orlando, Pensacola, Philadelphia, Phoenix, Portland, Raleigh, Roanoke, Sacramento, Salt Lake City, San Antonio, Scarborough, Seattle, St Louis, Syracuse, Tampa, The Bronx, Tucson, Virginia Beach, Weston, Worcester
Age
12 years and over
People
880 worldwide
Run by
Xenon Pharmaceuticals Inc.
See details and how to joinNCT05718817 · EU 2022-502282-24-00
No phaseTaking people
Mapping of Human Cognition
Where
Houston
Age
18 years to 75 years
People
75
Run by
The University of Texas Health Science Center, Houston
See details and how to joinNCT05989893
Phase 1/2Taking people
ASCEND: Safety and Tolerability of ION337 for the Treatment of Dravet Syndrome
Where
Ann Arbor, Durham, Memphis, Philadelphia, Rochester, Seattle
Age
2 years to 12 years
People
32 worldwide
Run by
Ionis Pharmaceuticals, Inc.
See details and how to joinNCT07531745
No phaseTaking people
HOBSCOTCH-YOUTH and Young Adults
Where
Lebanon
Age
13 years to 29 years
People
300
Run by
Dartmouth-Hitchcock Medical Center
See details and how to joinNCT07735715
Phase 3Taking people
Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (EPIC (EPIlepsy Cell Therapy))
Where
Aurora, Birmingham, Boston, Buffalo, Charlotte, Chicago, Dallas, Detroit, Durham, Great Neck, Houston, Iowa City, Lebanon, Little Rock, Los Angeles, Miami, Milwaukee, New Orleans, New York, Orange, Palo Alto, Philadelphia, Phoenix, Portland, Sacramento, Salt Lake City, San Diego, San Francisco, Seattle, St Louis, Syracuse, Tucson, Washington D.C., Winston-Salem
Age
18 years to 75 years
People
88
Run by
Neurona Therapeutics
See details and how to joinNCT05135091
No phaseNot yet taking people in United States
Lily's Grace Temporal Interference
Where
Madison
Age
18 years to 75 years
People
24
Run by
University of Wisconsin, Madison
See details and how to joinNCT07520955
Phase 1Taking people
Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy
Where
Bethesda
Age
18 years to 60 years
People
40
Run by
National Institute of Neurological Disorders and Stroke (NINDS)
See details and how to joinNCT02531880
Phase 3Taking people
A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
Where
Ann Arbor, Atlanta, Austin, Birmingham, Chicago, Cincinnati, Cleveland, Columbus, Dallas, Durham, Hackensack, Kissimmee, Little Rock, Los Angeles, Louisville, Marlboro, Memphis, Milwaukee, Morrisville, New Haven, New York, Omaha, Orange, Philadelphia, Salt Lake City, San Francisco, Seattle, Wilmington, Winston-Salem, Winter Park
Age
2 years and over
People
150 worldwide
Run by
Epygenix
See details and how to joinNCT04462770 · EU 2024-518628-57-00
No phaseNot yet taking people in United States
High-Intensity Focused Ultrasonic Ablation of the Centromedian Thalamic Nucleus for Treatment of Medically Refractory Generalized Epilepsy in Patients Ages 18 Years to 89 Years
Where
Portland
Age
18 years to 89 years
People
10
Run by
Oregon Health and Science University
See details and how to joinNCT07803692
Phase 2Enrolling by invitation
SPN-817 Open-Label Extension Study in Adults With Focal Onset Seizures
Where
Asheville, Kissimmee, Philadelphia, Port Charlotte, Rochester, Tucson, West Hills
Age
18 years and over
People
100 worldwide
Run by
Supernus Pharmaceuticals, Inc.
See details and how to joinNCT07141329 · EU 2026-526361-15-00
No phaseEnrolling by invitation
An Examination of Cognitive and Sensorimotor Processes in Patients With Epilepsy
Where
Great Neck
Age
5 years and over
People
450
Run by
Northwell Health
See details and how to joinNCT00859794
No phaseTaking people
Optimizing Brain Stimulation Parameters
Where
Rochester
Age
6 years and over
People
30
Run by
Mayo Clinic
See details and how to joinNCT06617845
No phaseTaking people
Diagnosing Epilepsy To EffeCT Change
Where
Ann Arbor, Billings, Birmingham, Boston, Charlotte, Clevland, Dallas, Durham, Houston, Indianapolis, Irvine, Jacksonville, Miami, Minneapolis, New Haven, Palo Alto, Philadelphia, Phoenix, Rochester, San Diego, St Louis, Tampa
Age
18 years to 75 years
People
210
Run by
Epiminder America, Inc.
See details and how to joinNCT07110337
Phase 1/2Taking people
A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome
Where
Ann Arbor, Aurora, Chicago, Columbus, Durham, Fort Worth, Miami, New York, Portland, Rochester, San Francisco
Age
6 months to 17 years
People
113 worldwide
Run by
Encoded Therapeutics
See details and how to joinNCT05419492
Phase 4Not yet taking people in United States
A Study to Investigate the Effect of Gradual Titration to Optimize Cannabidiol Treatment in Adults With LGS
Where
Fresno, New Orleans, Raleigh
Age
18 years and over
People
40
Run by
Jazz Pharmaceuticals
See details and how to joinNCT07728097