Familial hypercholesterolaemia trials in South Africa

In South Africa 7 Also abroad 115

7 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 1Taking people
Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia
Where
Cape Town, Johannesburg
Age
18 years to 70 years
People
132 worldwide
Run by
Verve Therapeutics, Inc.
See details and how to joinNCT06451770 · EU 2025-522617-39-00
Phase 3Taking people
Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 Studies
Where
Bloemfontein, Cape Town
Age
2 years to 100 years
People
195 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT05682378
Phase 3Not yet taking people in South Africa
Long-Term Efficacy and Safety of Lerodalcibep in Children and Adolescents With Familial Hypercholesterolemia
Where
Bloemfontein
Age
6 years to 17 years
People
150 worldwide
Run by
LIB Therapeutics LLC
See details and how to joinNCT07775339 · EU 2026-528022-38-00
Phase 3Enrolling by invitation
Study to Evaluate the Efficacy and Safety of Lerodalcibep in Children 6 to 17 Years, With Heterozygous FH
Where
Bloemfontein, Johannesburg
Age
6 years to 17 years
People
150 worldwide
Run by
LIB Therapeutics LLC
See details and how to joinNCT07102511 · EU 2025-524214-28-00
Phase 3Taking people
Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia
Where
Bloemfontein, Johannesburg
Age
2 years to 11 years
People
9 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06597006
Phase 3Taking people
Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia
Where
Bloemfontein
Age
6 years to 11 years
People
60 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06597019
No phaseTaking people
HoFH, the International Clinical Collaborators Registry
Where
Cape Town, Johannesburg
People
1,000 worldwide
Run by
University of Pennsylvania
See details and how to joinNCT04815005