Familial hypercholesterolaemia trials in United Kingdom

In United Kingdom 10 Also abroad 115

10 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 2/3Taking people
A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029)
Where
Birmingham, Sheffield, Southampton
Age
6 years to 17 years
People
153 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07058077 · EU 2024-519068-42-00
Phase 1Taking people
Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia
Where
Liverpool, London, Manchester
Age
18 years to 70 years
People
132 worldwide
Run by
Verve Therapeutics, Inc.
See details and how to joinNCT06451770 · EU 2025-522617-39-00
Phase 3Taking people
Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 Studies
Where
Middlesex
Age
2 years to 100 years
People
195 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT05682378
Phase 1Taking people
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
Where
Cambridge, London
Age
18 years to 75 years
People
90 worldwide
Run by
CRISPR Therapeutics AG
See details and how to joinNCT07491172
Phase 1Taking people
A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease
Where
Birmingham, Cambridge, Edinburgh, London, Manchester, Nottingham
Age
18 years to 70 years
People
85 worldwide
Run by
Verve Therapeutics, Inc.
See details and how to joinNCT06164730
Phase 3Taking people
Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial Hypercholesterolemia
Where
Southampton
Age
2 years to 11 years
People
9 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06597006
Phase 3Taking people
Phase 3 Clinical Study Evaluating Efficacy, Safety, and Tolerability of Obicetrapib Vs Bempedoic Acid to Treat Dyslipidemia in Adults With Primary Non-familial Hypercholesterolemia or Mixed Dyslipidemia at High to Very High Cardiovascular Risk, During a Treatment Period of Approximately 84 Days
Where
Stockton-on-Tees
Age
18 years and over
People
426
Run by
A. Menarini International Licensing S.A.
See details and how to joinNCT07614958 · EU 2025-524265-24-00
Phase 3Taking people
Study to Evaluate Efficacy and Safety of Inclisiran in Children With Heterozygous Familial Hypercholesterolemia
Where
London, West Midlands
Age
6 years to 11 years
People
60 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT06597019
No phaseEnrolling by invitation
Long-term Follow-up of Participants Dosed With an Investigational Gene Editing Therapy for Cardiovascular Disease
Where
London
Age
18 years and over
People
116 worldwide
Run by
Verve Therapeutics, Inc.
See details and how to joinNCT06112327
No phaseTaking people
EAS Familial Hypercholesterolaemia Studies Collaboration
Where
London
People
75,000
Run by
Imperial College London
See details and how to joinNCT04272697