Fatty liver disease (MASLD/MASH) trials in United Kingdom

In United Kingdom 24 Also abroad 366

24 trials · From ClinicalTrials.gov, checked 10 Nov 2026. Ask the study team whether a trial fits you.

Phase 2RecruitingTrial-stage medicine
Study to Evaluate ALN-CIDEB in Adults With Fibrotic Metabolic Dysfunction-Associated Steatohepatitis (MASH)
Where
Newcastle upon Tyne
Age
18 years to 75 years
People
360 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT07631637EU 2026-525916-33-00Registry updated 2026-11-09
Phase 3RecruitingTrial-stage medicine
A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis
Where
Birmingham, Cambridge, Liverpool, London, Newcastle upon Tyne
Age
18 years to 80 years
People
1,650 worldwide
Run by
Akero Therapeutics, Inc
See details and how to joinNCT06215716Registry updated 2026-11-06
Phase 3Not yet recruitingTrial-stage medicine
ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease
Where
Bradford, Leeds, Leicester, London, Plymouth
Age
18 years and over
People
600 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT07850063EU 2026-527091-88-00Registry updated 2026-10-30
Phase 3RecruitingTrial-stage medicine
LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis
Where
Aberdeen, Ashton in Makerfield, Bristol, Camberley, Dagenham, Edgbaston, Birmingham, Edgware, Enfield, London, Exeter, Glasgow, Hull, London, Newcastle upon Tyne, Northwood, Nottingham, Orpington, London, Preston, Rochdale, Sheffield, Southampton, Tooting, London, York
Age
18 years and over
People
1,800 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06632444EU 2024-513739-25-00Registry updated 2026-10-28
Phase 3RecruitingTrial-stage medicine
LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis
Where
Aberdeen, Bristol, Camberley, Derby, Edgbaston, Birmingham, Exeter, Glasgow, Hull, Liverpool, London, Newcastle upon Tyne, Northwood, Orpington, London, Preston, Rochdale, Sheffield, Southampton, Tooting, London, York
Age
18 years and over
People
1,590 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06632457EU 2024-513741-36-00Registry updated 2026-10-28
Phase 3RecruitingTrial-stage medicine
A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)
Where
Bristol, Glasgow, High Wycombe, Hull, London, Oxford, Portsmouth, Preston, Southampton, Stockton, Sunderland, Swansea, York
Age
18 years to 80 years
People
1,350 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT06318169EU 2023-509912-27-00Registry updated 2026-10-23
Phase 3RecruitingTrial-stage medicine
A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH
Where
Aberdeen, Bristol, Leeds, London, Oxford, Plymouth, Portsmouth, Port Talbot, Southampton
Age
18 years to 75 years
People
1,800 worldwide
Run by
Hoffmann-La Roche
See details and how to joinNCT06419374EU 2023-510395-31-00Registry updated 2026-10-23
Phase 3RecruitingTrial-stage medicine
A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH
Where
Birmingham, London, Newcastle upon Tyne, Nottingham, Whitechapel
Age
18 years to 80 years
People
2,150 worldwide
Run by
Akero Therapeutics, Inc
See details and how to joinNCT06528314Registry updated 2026-10-13
Phase 3RecruitingTrial-stage medicine
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
Where
Aberdeen, Clifton, Enfield, Glasgow, Ipswich, Liverpool, London, Newcastle upon Tyne, Oxford, Penzance, Preston, Rochdale, Sheffield, York
Age
18 years and over
People
4,500 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07165028EU 2025-522674-36-00Registry updated 2026-10-08
No phaseRecruitingResearch participation
Development of a Non-invasive Screening Tool to Predict Metabolic Dysfunction-associated Steatotic Liver Disease
Where
London
Age
18 years to 80 years
People
2,000
Run by
Richmond Research Institute
See details and how to joinNCT04873258Registry updated 2026-08-19
Phase 4RecruitingTrial-stage medicine
Fibrosis Lessens After Metabolic Surgery
Where
Bristol, London
Age
18 years to 75 years
People
120 worldwide
Run by
The Cleveland Clinic
See details and how to joinNCT06374875Registry updated 2026-07-31
No phaseRecruitingResearch participation
Fructose is a Metabolic and Inflammatory Pathogenic Factor in Metabolic Dysfunction-associated Steatohepatitis (MASH)
Where
London
Age
45 years to 65 years
People
72
Run by
Queen Mary University of London
See details and how to joinNCT07013916Registry updated 2026-07-31
No phaseRecruitingResearch participation
The Impact of Pectin Supplementation on Systematic Inflammation Pathway, Gut Microbiome, and Metabolic Health in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Where
Nottingham
Age
18 years and over
People
45
Run by
University of Nottingham
See details and how to joinNCT07093346Registry updated 2026-07-29
No phaseNot yet recruitingResearch participation
Temporal Eating Patterns and Metabolic Health
Where
Cambridge
Age
18 years to 80 years
People
400
Run by
Maria Chondronikola
See details and how to joinNCT07630636Registry updated 2026-06-08
No phaseRecruitingResearch participation
Investigating Pathological Mechanisms in Non-alcoholic Fatty Liver Disease
Where
London
Age
18 years and over
People
153
Run by
Queen Mary University of London
See details and how to joinNCT04141592Registry updated 2026-06-05
Phase 1/2RecruitingTrial-stage medicine
Study of TGM-312-SC01 in Healthy Participants and Adults With MASH
Where
London
Age
18 years to 70 years
People
99
Run by
Tangram Therapeutics Plc
See details and how to joinNCT07427680Registry updated 2026-05-19
Phase 3RecruitingTrial-stage medicine
A PROspective Faecal MIcrobiota tranSplantation Trial to Improve outcomEs in Patients With Cirrhosis
Where
Basildon, Bournemouth, Bristol, Chelmsford, Derby, Dundee, Gateshead, Glasgow, Hull, Inverness, Leeds, London, Newcastle upon Tyne, Newport, Nottingham, Plymouth, Southampton, Torquay
Age
18 years and over
People
300
Run by
King's College London
See details and how to joinNCT06461208Registry updated 2026-02-24
No phaseRecruitingResearch participation
Integrated Diagnostics for Early Diagnosis of Liver Disease
Where
Manchester
Age
18 years and over
People
1,200
Run by
Manchester University NHS Foundation Trust
See details and how to joinNCT04666402Registry updated 2026-02-09
No phaseRecruitingResearch participation
The COherence of Scatter Identification and Exclusion Algorithm Study
Where
London
Age
18 years and over
People
15
Run by
Institute of Cancer Research, United Kingdom
See details and how to joinNCT06975579Registry updated 2025-05-16
Phase 4Not yet recruitingResearch participation
Digital Diet and Exercise Intervention to Reduce Liver Fibrosis in Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)
Where
London
Age
18 years and over
People
100
Run by
St. George's Hospital, London
See details and how to joinNCT06920316Registry updated 2025-04-09
No phaseNot yet recruitingResearch participation
Long-term Follow-up to Determine Outcome in Liver Disease (LOVE Study)
Where
Newcastle upon Tyne
Age
18 years and over
People
30,000 worldwide
Run by
Universität des Saarlandes
See details and how to joinNCT06907563Registry updated 2025-04-02
Phase 1RecruitingTrial-stage medicine
COmmencing Menopausal HOrmone Replacement Therapy and the Effect on Metabolic-dysfunction Associated Steatotic Liver Disease: a Pilot Mechanistic Study
Where
Oxford
Age
18 years and over
People
10
Run by
University of Oxford
See details and how to joinNCT06704516Registry updated 2025-01-13
No phaseRecruitingResearch participation
The European NAFLD Registry
Where
Birmingham, Cambridge, Gateshead, Hull, London, Newcastle upon Tyne, Nottingham, Oxford, Plymouth, Portsmouth
Age
18 years to 100 years
People
10,000 worldwide
Run by
Newcastle University
See details and how to joinNCT04442334Registry updated 2023-01-06
No phaseRecruitingResearch participation
European Paediatric Non-Alcoholic Fatty Liver Disease Registry (EU-PNAFLD)
Where
Birmingham, Cambridge
Age
Up to 18 years
People
2,000 worldwide
Run by
Cambridge University Hospitals NHS Foundation Trust
See details and how to joinNCT04190849Registry updated 2022-03-04

All Fatty liver disease (MASLD/MASH) trials and the map

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