Glioblastoma: open trials in France

• NCT06641908

  Anti-GD2 ADC M3554 in Advanced Solid Tumors

  Trial Treatment · Phase 1 · EMD Serono Research & Development Institute, Inc.

  Institut Bergonié - Service d'Oncologie Médicale, Bordeaux · Centre Oscar Lambret - cancerologie generale, Lille · Centre Leon Berard - Service d'Oncologie Medicale, Lyon · Centre Antoine Lacassagne - Service d'Hématologie Oncologie, Nice

  Registry updated 2026-11-05

• NCT03970447

  A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

  Trial Treatment · Phase 2/3 · Global Coalition for Adaptive Research

  Hospital Pierre Wertheimer, Bron · Centre Hospitalier Regional De Marseille, Marseille · Assistance Publique Hopitaux de Paris, Paris

  Registry updated 2026-11-02

• NCT07867886

  An Optimization Study Evaluating Safety and Efficacy of the Y-90 Glioblastoma (GBM) Device in Patients With Recurrent GBM

  Trial Treatment · Boston Scientific Corporation

  Hospices Civils de Lyon - Hopital Louis Pradel, Bron · Hopital de la Timone, Marseille

  Registry updated 2026-10-09

• NCT03212742

  Phase I/IIa study of concomitant radiotherapy with olaparib and temozolomide in unresectable high grade gliomas patients

  Trial Treatment · Phase 1 · Centre Francois Baclesse

  CHU De Medecine Interne, Amiens Cedex 2 · Institut de Cancerologie de L'Ouest, Angers · CHU De Bordeaux, Bordeaux Cedex · Centre Francois Baclesse, Caen Cedex 5 · Centre de Radiothérapie Guillaume le Conquérant, LE HAVRE · Groupe Hospitalier Du Havre, Le Havre Cedex · Groupe Hospitalier Bretagne Sud, Lorient · Centre Leon Berard, Lyon · Hopitaux Universitaires Pitie Salpetriere, Paris · Institut Curie, Paris · Centre Henri Becquerel, Rouen Cedex · Institut De Cancerologie De L Ouest, Saint-Herblain Cedex · Oncopole Claudius Regaud, Toulouse

  Registry updated 2026-09-25

• NCT04094610

  A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations

  Trial Treatment · Phase 1/2 · Turning Point Therapeutics, Inc.

  Centre Hospitalier Universitaire D'Angers, Angers · Pellegrin Hospital, Bordeaux · Centre Leon Berard, Lyon · Assistance Publique Hôpitaux de Marseille, Marseille · Institut Gustave Roussy, Villejuif

  Registry updated 2026-09-25

• NCT07568782

  Impact of Fluorescence-Guided Resection and Chemoradiotherapy on the Systemic Immune Response in Glioblastoma: A Kinetic Analysis of Immune Biomarkers.

  Research · University Hospital, Lille

  CHU Lille, Lille

  Registry updated 2026-09-24

• NCT07788430

  Impact of Pesticide Exposure on Survival and Tumor Aggressiveness in Patients With Glioblastoma: A Prospective Clinical Study

  Trial Treatment · Institut Claudius Regaud

  Institut Universitaire du Cancer de Toulouse - Oncopole, Toulouse

  Registry updated 2026-08-26

• NCT07173829

  A Study to Better Understand the Biological and Molecular Mechanisms Involved in Glioblastoma Recurrence and Progression

  Research · University Hospital, Bordeaux

  CHU de Bordeaux, Bordeaux

  Registry updated 2026-08-07

• 2023-508662-15-00

  RIVKAL clinical trial for the first-in-human administration of BIM2b in participants with Glioblastoma

  Trial Treatment · Phase 1 · Beta Innov

  Hopital D Instruction Des Armées Percy, Clamart

  Registry updated 2026-07-21

• NCT06622434

  New Adjuvant Vaccine in Glioblastoma, a Phase 1/2a Study

  Trial Treatment · Phase 1/2 · Assistance Publique - Hôpitaux de Paris

  CHU Besançon, Besançon · Centre Hospitalier Regional De Marseille, Marseille · Assistance Publique Hopitaux de Paris, Paris · Assistance Publique Hopitaux De Paris, Paris Cedex 13 · Centre De Lutte Contre Le Cancer Eugene Marquis, Rennes Cedex

  Registry updated 2026-06-11

• NCT05904119

  Lomustine With and Without Reirradiation for First Progression of Glioblastoma: a Randomized Phase III Study

  Trial Treatment · Phase 3 · European Organisation for Research and Treatment of Cancer - EORTC

  Centre Hospitalier Universitaire Amiens Picardie, Amiens Cedex 1 · Hospices Civils de Lyon, Bron · Centre Jean Perrin, Clermont Ferrand Cedex1 · Centre Hospitalier Universitaire De Lille, Lille Cedex · Centre Hospitalier Universitaire de Nice, Nice · Assistance Publique Hopitaux de Paris, Paris · Assistance Publique Hopitaux De Paris, Paris Cedex 13 · Institut De Cancerologie De L Ouest, St Herblain · Institut de Cancérologie Strasbourg Europe, Strasbourg

  Registry updated 2026-06-08

• NCT07274397

  Assessment of Early Post-operative Nuclear Imaging in Neurosurgery: a Safety and Feasibility Study in Patients Operated for Glioblastoma

  Trial Treatment · Beta Emitting Accurate Monitored Systems

  Hôpital Henri Mondor - Université Paris-Est Créteil (UPEC), Créteil

  Registry updated 2026-06-08

• NCT07628257

  Cerebral Connectivity and Metabolic Phenotype of Gliomas: Prospective Addition of DTI and Rs-fMRI to a Preoperative FDG PET Strategy, With Neuropsychological Correlates and Post-treatment Follow-up

  Trial Treatment · Centre Paul Strauss

  Institut public de cancérologie Strauss Europe, Strasbourg

  Registry updated 2026-06-04

• NCT07472387

  Impact of Androgen Signaling on the Composition of the Immune Microenvironment in Glioblastomas

  Trial Treatment · Assistance Publique - Hôpitaux de Paris

  Neuro-oncology department, Pitié Salpêtrière hospital, Paris

  Registry updated 2026-03-16

• NCT06222138

  Study of Biologic Tumor and Plasma Biomarkers of Response to TTFields in Patients Treated for Newly Diagnosed Glioblastoma

  Trial Treatment · Institut Claudius Regaud

  IUCT-O, Toulouse

  Registry updated 2026-02-13

• NCT05653622

  Simultaneous Integrated Boost FDOPA Positron Emission Tomography (PET) Guided in Patients With Partially- or Non-operated Glioblastoma

  Trial Treatment · Phase 2 · Centre Paul Strauss

  CHRU de Nancy, Nancy · Centre Paul Strauss, Strasbourg · ICL, Vandœuvre-lès-Nancy

  Registry updated 2026-02-04

• NCT05653635

  Contribution From PET-DOPA in Glioblastoma Re-irradiation - A Randomized Phase II Study

  Trial Treatment · Phase 2 · Centre Paul Strauss

  CHRU de Nancy, Nancy · Centre Paul Strauss, Strasbourg

  Registry updated 2026-02-04

• NCT02394626

  Surgery for Recurrent Glioblastoma

  Trial Treatment · Phase 2 · Insel Gruppe AG, University Hospital Bern

  Centre Hospitalier Universitaire Dijon Bourgogne, Department of Neurosurgery, Dijon · Hospices Civils de Lyon - CHU de Lyon, Department of Neuro-Oncology, Lyon · Assistance Publique - Hôpitaux de Marseille, Department of Neuro-Oncology, Marseille · Centre Hospitalier Universitaire de Nice, Department of Neurosurgery, Nice · Assistance Publique - Hôpitaux de Paris (AP-HP), Department of Neurosurgery, Paris · Centre Hospitalier Universitaire de Saint-Étienne, Department of Neurosurgery, Saint-Etienne · Institut de Cancérologie Strasbourg Europe (ICANS), Department of Oncology, Strasbourg · Centre Hospitalier Régional et Universitaire de Tours (CHRU Tours), Department of Neurosurgery, Tours

  Registry updated 2026-02-02

• NCT03526822

  Prospective Cohort of Patients With Newly Diagnosed Glioblastoma: Analysis of MMP2 and MMP9 Expression and Correlation to Neuro-imaging Features.

  Trial Treatment · Assistance Publique Hopitaux De Marseille

  Assistance Publique Hôpitaux de Marseille, Marseille

  Registry updated 2026-01-28

• NCT03144167

  Study of Prognostic Biomarkers of Survival at 6 Months for Patients Treated With Bevacizumab Glioblastomas in First Relapse After Failure of Radiochemotherapy

  Trial Treatment · Centre Hospitalier Universitaire, Amiens

  Chu Amiens Picardie, Amiens

  Registry updated 2026-01-16

• NCT07347210

  Evaluation of UCPVax Vaccine +/- Pembrolizumab Combined With Standard Treatment as Adjuvant Therapy in Patients With Unmethylated MGMT Glioblastoma

  Trial Treatment · Phase 2 · Centre Hospitalier Universitaire de Besancon

  Centre Hospitalier Regional Universitaire, Besancon Cedex · Centr Georges Francois Leclerc, Dijon · Centre Hospitalier Regional De Marseille, Marseille · Hopital Saint Louis, Paris

  Registry updated 2026-01-16

• NCT05370079

  Control Cohort CTRL COH

  Trial Treatment · Hospices Civils de Lyon

  Hospices Civils de Lyon, Bron

  Registry updated 2026-01-15

• NCT04945148

  Oxidative Phosphorylation Targeting In Malignant Glioma Using Metformin Plus Radiotherapy Temozolomide

  Trial Treatment · Phase 2 · Hopital Foch

  Hospices Civils de Lyon, Bron · Timone University Hospital, Marseille · Hopitaux Universitaires Pitie Salpetriere, Paris · Hopital Saint Louis, Paris · Hospital Foch, Suresnes

  Registry updated 2025-11-21

• NCT07211841

  Correlative Analysis Between Magnetic Resonance Spectroscopy (MRS) and Essential Clinicobiological Data in Glioblatoma Multiforme (GBM)

  Trial Treatment · Centre Hospitalier Universitaire, Amiens

  CHU Amiens, Amiens

  Registry updated 2025-11-19

• NCT03958240

  Deciphering Mechanisms Underlying Cancer Immunogenicity

  Trial Treatment · Institut Claudius Regaud

  Hopital Rangueil, Toulouse · Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse · Hopital Larrey, Toulouse

  Registry updated 2025-09-15

All Glioblastoma trials and the map

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