Head and neck cancer trials in Germany

In Germany 51 Also abroad 942

51 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 1/2Taking people
First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors
Where
Erlangen
Age
18 years and over
People
880 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT05768139 · EU 2023-504807-94-00
Phase 2Taking people
A Phase II Randomized Clinical Trial Comparing Two Cycles Versus Four Cycles of Combination Therapy with Cetuximab, Avelumab, Cisplatin, and Docetaxel in Patients with Recurrent Metastatic Head and Neck Cancer - AVETUX-HN
Where
Aachen, Berlin, Essen, Hanover, Stuttgart
Age
18 years and over
People
126
Run by
Charite Universitaetsmedizin Berlin KöR
See details and how to join2025-521738-27-00 · EU 2025-521738-27-00
Phase 1/2Taking people
Afatinib in Patients With Fanconi Anemia (FA) and Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)
Where
Hanover
Age
18 years and over
People
25 worldwide
Run by
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
See details and how to joinNCT06648096 · EU 2024-511477-29-00
Phase 3Taking people
A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma
Where
Augsburg, Berlin, Erlangen, Essen, Giessen, Hamburg, Straubing
Age
18 years and over
People
864 worldwide
Run by
GlaxoSmithKline
See details and how to joinNCT06256588 · EU 2023-508613-17-00
Phase 3Taking people
A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma
Where
Berlin, Freiburg im Breisgau, Munich
Age
18 years and over
People
410 worldwide
Run by
AVEO Pharmaceuticals, Inc.
See details and how to joinNCT06064877 · EU 2023-505606-42-00
No phaseTaking people
The Head and Neck Registry of the European Reference Network on Rare Adult Solid Cancers
Where
Essen
Age
18 years and over
People
13,600 worldwide
Run by
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
See details and how to joinNCT05483374
No phaseTaking people
Carbon Ion Re-Radiotherapy in Patients With Recurrent or Progressive Locally Advanced Head-and-Neck Cancer
Where
Heidelberg, Marburg
Age
18 years and over
People
72
Run by
University Hospital Heidelberg
See details and how to joinNCT04185974
Phase 2/3Taking people
De-Intensification of Postoperative Radiotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck
Where
Erlangen
Age
18 years and over
People
508
Run by
University of Erlangen-Nürnberg Medical School
See details and how to joinNCT06030440
No phaseTaking people
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
Where
Tübingen
Age
18 years and over
People
8,000 worldwide
Run by
UMC Utrecht
See details and how to joinNCT04075305
No phaseNot yet taking people in Germany
Neutrophil Biomarker Test for Predicting Clinical Benefit From Immunotherapy Based on Flow Cytometry Analysis
Where
Heidelberg
Age
18 years and over
People
600 worldwide
Run by
OncoHost Ltd.
See details and how to joinNCT07246759
No phaseTaking people
De-escalation of Adjuvant Radio (Chemo) Therapy for HPV-positive Head-neck Squamous Cell Carcinomas
Where
Berlin, Dresden, Essen, Frankfurt am Main, Freiburg im Breisgau, Heidelberg, München, Regensburg, Tübingen
Age
18 years and over
People
304
Run by
Technische Universität Dresden
See details and how to joinNCT03396718
No phaseTaking people
Clinical Benefit and Biomarker Analysis of Combination of PD-1/PD-L1 Immune Checkpoint Inhibitors and Radiotherapy
Where
Erlangen
Age
18 years and over
People
200
Run by
University of Erlangen-Nürnberg Medical School
See details and how to joinNCT04892849
No phaseTaking people
Topical Application of PRF Before Radiation Therapy
Where
Giessen
Age
18 years to 99 years
People
34
Run by
University of Giessen
See details and how to joinNCT06406530
No phaseTaking people
Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy
Where
Berlin, Erlangen, Frankfurt, Giessen, Halle, Jena, Kiel, Leipzig, Mainz, Munich, Würzburg
Age
65 years and over
People
1,500 worldwide
Run by
University Hospital Freiburg
See details and how to joinNCT05337631
No phaseTaking people
Radiotherapy of Head and Neck Cancer With SIB
Where
Würzburg
Age
18 years and over
People
750
Run by
Wuerzburg University Hospital
See details and how to joinNCT06831903
No phaseTaking people
Non-invasive Preoperative Tissue Evaluation in Head and Neck Tumor Patients Using Multispectral Optoacoustic Tomography (MSOT)
Where
Erlangen
Age
18 years and over
People
40
Run by
University of Erlangen-Nürnberg Medical School
See details and how to joinNCT06716892
Phase 2Taking people
European Larynx Organ Preservation Study (ELOS) [MK-3475-C44]
Where
Cologne, Jena, Leipzig, Mannheim, München, Potsdam, Regensburg, Ulm, Würzburg
Age
18 years to 70 years
People
140
Run by
University of Leipzig
See details and how to joinNCT06137378 · EU 2022-502751-61-00
No phaseTaking people
Stereotactic Body Radiotherapy in Patients With Rare Oligometastatic Cancers (OligoRARE)
Where
Hamburg
Age
18 years and over
People
200 worldwide
Run by
European Organisation for Research and Treatment of Cancer - EORTC
See details and how to joinNCT04498767
Phase 2Taking people
Phase II Trial of Neoadjuvant and Adjuvant IO102-IO103 and Pembrolizumab KEYTRUDA® in Patients With Resectable Tumors
Where
Essen, Heidelberg
Age
18 years and over
People
60 worldwide
Run by
IO Biotech
See details and how to joinNCT05280314
No phaseTaking people
Artificial Intelligence in Functional Imaging for Individualized Treatment of Head and Neck Squamous Cell Carcinoma Patients
Where
Berlin
Age
18 years and over
People
250
Run by
Charite University, Berlin, Germany
See details and how to joinNCT05192655
No phaseTaking people
Online Adaptive Radiotherapy Using a Novel Linear Accelerator (ETHOS)
Where
Berlin
Age
18 years and over
People
649
Run by
Charite University, Berlin, Germany
See details and how to joinNCT06116019
Phase 2Not yet taking people in Germany
Individualized Radiation Dose Prescription in HNSCC Based on F-MISO-PET Hypoxia-Imaging
Where
Berlin, Dresden, Freiburg im Breisgau, Heidelberg, Leipzig, Mannheim, München, Würzburg
Age
18 years and over
People
276
Run by
Technische Universität Dresden
See details and how to joinNCT03865277
No phaseTaking people
Immune Biomarker Study for Head and Neck Cancer
Where
Erlangen
Age
18 years and over
People
1,100
Run by
University of Erlangen-Nürnberg Medical School
See details and how to joinNCT05375266
No phaseTaking people
Prediction of Malignant Transformation of Oral Leukoplakia Using a MAGE-A-based Immunoscore
Where
Erlangen
Age
18 years to 80 years
People
500
Run by
University of Erlangen-Nürnberg Medical School
See details and how to joinNCT03975322
No phaseTaking people
Feasibility of Online MR-guided Radiotherapy on a 1.5T MR-Linac
Where
Tübingen
Age
18 years and over
People
472
Run by
University Hospital Tuebingen
See details and how to joinNCT04172753