Heart failure trials in Canada

In Canada 80 Also abroad 1265

80 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
Where
Cambridge, Chicoutimi, Greenfield Park, Hamilton, London, Montreal, Newmarket, New Westminster, North Vancouver, North York, Oakville, Oshawa, Ottawa, Peterborough, Saint-Jean-sur-Richelieu, Sydney, Thunder Bay, Toronto, Trois-Rivières, Vancouver, Waterloo, Winnipeg
Age
18 years to 130 years
People
3,850 worldwide
Run by
AstraZeneca
See details and how to joinNCT06307652 · EU 2023-508162-15-00
No phaseTaking people
Alleviant ALLAY-HFrEF Study
Where
Montreal, Newmarket, Québec
Age
18 years and over
People
350 worldwide
Run by
Alleviant Medical, Inc.
See details and how to joinNCT06812533
No phaseTaking people
Surgical Ablation of AF Efficacy Trial
Where
Hamilton
Age
18 years and over
People
2,000
Run by
Population Health Research Institute
See details and how to joinNCT05434819
Phase 2Taking people
A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
Where
Brampton, Hamilton, Mississauga, Ottawa, Québec, Toronto, Vancouver, Winchester
Age
40 years to 84 years
People
200 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT06979362 · EU 2024-515796-35-00
Phase 3Taking people
COLchicine and Thiamine in Heart Failure Due to Ischemic Heart Disease
Where
Hamilton
Age
45 years and over
People
2,500 worldwide
Run by
Hamilton Health Sciences Corporation
See details and how to joinNCT05873881 · EU 2023-506675-96-00
Phase 1Taking people
A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction
Where
Montreal
Age
18 years to 100 years
People
12 worldwide
Run by
Novartis Pharmaceuticals
See details and how to joinNCT07465653
Phase 3Taking people
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
Where
Barrie, Etobicoke, Greater Sudbury, Hamilton, Kingston, London, Markham, Montreal, Newmarket, North York, Oakville, Ottawa, Stoney Creek, Thunder Bay, Toronto, Trois-Rivières
Age
18 years and over
People
6,950 worldwide
Run by
AstraZeneca
See details and how to joinNCT07761117 · EU 2026-526304-79-00
Phase 3Taking people
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
Where
Calgary, Cambridge, Edmonton, Greater Sudbury, Kamloops, London, North Vancouver, North York, Regina, Sherbrooke, Surrey, Toronto, Vancouver, Winnipeg
Age
18 years and over
People
5,200 worldwide
Run by
Colorado Prevention Center
See details and how to joinNCT06008197
Phase 3Taking people
A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)
Where
Edmonton, Greater Sudbury, London, Montreal, North York, Sherbrooke, Surrey, Toronto
Age
18 years and over
People
1,500 worldwide
Run by
Colorado Prevention Center
See details and how to joinNCT06024746
Phase 2/3Taking people
Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension
Where
Ottawa
Age
18 years and over
People
56
Run by
Ottawa Heart Institute Research Corporation
See details and how to joinNCT06405555
Phase 2Taking people
COgnitioN With VERiciGuat Evaluation in Heart Failure
Where
Calgary, Edmonton, Montreal, Ottawa
Age
18 years and over
People
120
Run by
University of Alberta
See details and how to joinNCT06601465
No phaseTaking people
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Where
Montreal, Toronto
Age
0 years to 20 years
People
5,000 worldwide
Run by
Duke University
See details and how to joinNCT04278404
Phase 3Taking people
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
Where
Burlington, Calgary, Chicoutimi, Courtice, Halifax, Hamilton, Kingston, Moncton, Montreal, North York, Oakville, Peterborough, Québec, Rimouski, Saint-Charles-Borromée, Scarborough Village, Sherbrooke, Toronto, Trois-Rivières, Vancouver, Waterloo, Winchester, Winnipeg
Age
18 years and over
People
5,610 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT07567001 · EU 2025-523717-29-00
No phaseTaking people
Alleviant ALLAY-HF Study
Where
Montreal, Newmarket
Age
40 years and over
People
700 worldwide
Run by
Alleviant Medical, Inc.
See details and how to joinNCT05685303
No phaseTaking people
VIrtual Care To Improve Outcomes and RecoverY From Heart Failure Hospitalization
Where
Hamilton, Thunder Bay, Toronto
Age
18 years and over
People
891 worldwide
Run by
Population Health Research Institute
See details and how to joinNCT05724433
Phase 2Taking people
Lumacaftor Yields Reversal of Impaired Cerebral Blood Flow in Heart Failure Patients
Where
Toronto
Age
18 years and over
People
60
Run by
Qanatpharma AG
See details and how to joinNCT07695090
Phase 3Taking people
A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists
Where
Calgary, Edmonton, Greater Sudbury, Kingston, London, North Vancouver, North York, Sherbrooke, Surrey, Toronto, Victoria, Winnipeg
Age
18 years and over
People
2,600 worldwide
Run by
Colorado Prevention Center
See details and how to joinNCT06033950
Phase 4Taking people
The STOP-MED CTRCD Trial
Where
Edmonton, Hamilton, Ottawa, Toronto, Winnipeg
Age
18 years and over
People
335 worldwide
Run by
Dinesh Thavendiranathan
See details and how to joinNCT06183437
No phaseTaking people
Ted Rogers Understanding of Exacerbations in Heart Failure 2: Monitor
Where
Newmarket, Toronto
Age
18 years and over
People
360
Run by
University Health Network, Toronto
See details and how to joinNCT07447908
No phaseTaking people
RAFT - Pace &Ablate
Where
Halifax, Hamilton, Kitchener, London, Montreal, Newmarket, Ottawa, Québec, Sherbrooke, Toronto, Victoria
Age
18 years and over
People
600
Run by
Habib Khan
See details and how to joinNCT06299514
No phaseTaking people
MedlyPeds Feasibility Study
Where
Toronto
Age
8 years to 18 years
People
30
Run by
The Hospital for Sick Children
See details and how to joinNCT07556185
Phase 2Taking people
Inhaled Milrinone and Epoprostenol for the Prevention of Difficult Cardiac Pulmonary Bypass Separation
Where
Montreal
Age
18 years and over
People
141
Run by
Montreal Heart Institute
See details and how to joinNCT05450328
No phaseTaking people
JUdicious Surveillance for Trastuzumab Induced Cardiotoxicity in the First Year
Where
Toronto
Age
18 years to 79 years
People
300
Run by
Women's College Hospital
See details and how to joinNCT06930521
No phaseTaking people
3D Assessment of RV Function in Patients Undergoing LVAD Implantation
Where
Edmonton
Age
16 years and over
People
200
Run by
University of Alberta
See details and how to joinNCT05376254
No phaseTaking people
Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment
Where
Calgary, Hamilton, Montreal, Ottawa, Québec, Toronto
People
420 worldwide
Run by
Children's Oncology Group
See details and how to joinNCT01790152