Heart failure trials in Italy

In Italy 104 Also abroad 1277

59 of 104 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 15 November 2026. Ask the study team whether a trial fits you.

Phase 2/3Taking people
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
Where
Bergamo, Bologna, Florence, Genoa, Milan, Padova, Rome, Turin
Age
29 days to 17 years
People
342 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT05714085 · EU 2022-501238-52-00
Phase 3Taking people
CMP-MYTHiC Trial and Registry - CardioMyoPathy With MYocarditis THerapy With Colchicine
Where
Ancona, Arezzo, Bologna, Milan, Naples, Roma, Rome, Trieste, Turin, Udine
Age
18 years and over
People
80
Run by
Niguarda Hospital
See details and how to joinNCT06158698
Phase 3Taking people
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity (MARITIME-HF)
Where
Bari, Bergamo, Brescia, Cortona, Foggia, Forli', Milan, Naples, Parma, Pavia, Rimini, Rivoli, Rome, Rozzano, Sassari
Age
18 years and over
People
2,787 worldwide
Run by
Amgen Inc.
See details and how to join2024-516654-22-00
Phase 3Taking people
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Where
Bergamo, Foggia, Genoa, Naples, Pavia, Rome, Rozzano
Age
18 years and over
People
6,712 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06424288 · EU 2023-509706-30-00
Phase 3Taking people
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
Where
Bergamo, Naples, Pavia, Pisa, Rome, Rozzano
Age
18 years and over
People
4,200 worldwide
Run by
Boehringer Ingelheim
See details and how to joinNCT06935370 · EU 2024-519525-38-00
Phase 2Not yet taking people in Italy
A Study to Evaluate the Safety and Efficacy of AC01 Compared to Placebo in Participants With Chronic Heart Failure
Where
Ancona, Bologna, Brescia, Caserta, Ferrara, Milan, Naples, Pavia, Rome, Rozzano, Siena, Trieste
Age
18 years to 85 years
People
400 worldwide
Run by
AnaCardio AB
See details and how to joinNCT07584967 · EU 2025-524469-25-00
Phase 2Not yet taking people in Italy
A Study of Bimagrumab in Participants With HFpEF
Where
Caserta, Torino
Age
18 years and over
People
540 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07920887 · EU 2026-527983-34-00
No phaseTaking people
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
Where
Turin
Age
18 years and over
People
850 worldwide
Run by
Abbott Medical Devices
See details and how to joinNCT06526195
Phase 3Taking people
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
Where
Arzignano, Bergamo, Brescia, Ferrara, Milan, Perugia, Rimini, Rome, Sesto San Giovanni
Age
18 years to 85 years
People
1,800 worldwide
Run by
Cytokinetics
See details and how to joinNCT06736574 · EU 2024-519219-32-00
Phase 3Taking people
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Where
Bari, Bergamo, Brescia, Cortona AR, Foggia, Forlì, Milan, Naples, Parma, Pavia, Rimini, Rivoli, Roma, Sassari
Age
18 years to 99 years
People
5,056 worldwide
Run by
Amgen
See details and how to joinNCT07037459
Phase 3Taking people
A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
Where
Bergamo, Bologna, Genoa, Milan, Naples, Padova, Rome, Turin
Age
Up to 18 years
People
117 worldwide
Run by
Bayer
See details and how to joinNCT07192952 · EU 2024-519830-22-00
Phase 3Taking people
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
Where
Alexandria, Bari, Bergamo, Brescia, Chiavari, Ferrara, Foggia, Milan, Monza, Naples, Novara, Orbassano, Palermo, Pavia, Potenza, Rome, Rozzano, Siena, Turin, Udine
Age
40 years and over
People
11,300 worldwide
Run by
AstraZeneca
See details and how to joinNCT06677060 · EU 2024-514506-32-00
Phase 3Taking people
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
Where
Ancona - Torrette, Bologna, Bolzano, Brescia, Cona, Florence, Ivrea, Lecco, Messina, Milan, Naples, Orbassano, Palermo, Pavia, Perugia, Pisa, Roma, Rome, San Donato Milanese, Trieste
Age
18 years and over
People
1,280 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT07207811
No phaseTaking people
The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)
Where
Roma
Age
18 years and over
People
754 worldwide
Run by
Sunnybrook Health Sciences Centre
See details and how to joinNCT05427370
Phase 4Taking people
Pharmacological Optimization in Prevention in Heart Failure: A Sex-gap?
Where
Ancona, Cecina, Ferrara, Florence, Milan, Pisa, Ravenna, Reggio Emilia, Roma, San Donato Milanese
Age
18 years to 85 years
People
368
Run by
IRCCS Policlinico S. Donato
See details and how to joinNCT07295522
Phase 3Taking people
A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
Where
Bergamo, Bologna, Genoa, Milan, Naples, Padova, Rome, Turin
Age
6 months to 17 years
People
111 worldwide
Run by
Bayer
See details and how to joinNCT07188805 · EU 2024-519829-38-00
Phase 3Taking people
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
Where
Acquaviva delle Fonti, Bari, Bergamo, Brescia, Catania, Catanzaro, Cona, Cortona, Florence, Milan, Novara, Pavia, San Giovanni Rotondo
Age
18 years to 130 years
People
3,850 worldwide
Run by
AstraZeneca
See details and how to joinNCT06307652 · EU 2023-508162-15-00
No phaseTaking people
Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)
Where
Ancona, Bergamo, Milan
Age
22 years and over
People
400 worldwide
Run by
Reprieve Cardiovascular, Inc
See details and how to joinNCT06898515
No phaseTaking people
Artificial Voice Analysis and Telemonitoring for Heart Failure. A Feasibility Study
Where
Milan
Age
18 years and over
People
60
Run by
Niguarda Hospital
See details and how to joinNCT07664748
No phaseNot yet taking people in Italy
Remote Monitoring and Optimization of Heart Failure Therapy
Where
Roma
Age
18 years to 85 years
People
800 worldwide
Run by
Zoll Medical Corporation
See details and how to joinNCT07622472
Phase 3Taking people
COLchicine and Thiamine in Heart Failure Due to Ischemic Heart Disease
Where
Ancona, Bari, Bergamo, Busto Arsizio, Catania, Cesena, Foggia, Lecco, Milan, Palermo, Perugia, Reggio Emilia, Rimini, Rome, San Donato Milanese
Age
45 years and over
People
2,500 worldwide
Run by
Hamilton Health Sciences Corporation
See details and how to joinNCT05873881 · EU 2023-506675-96-00
Phase 3Not yet taking people in Italy
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
Where
Ancona, Bergamo, Brescia, Milan, Pavia, Perugia, Riccione, Salerno, Sesto San Giovanni, Vizzolo Predabissi (MI)
Age
18 years and over
People
6,950 worldwide
Run by
AstraZeneca
See details and how to joinNCT07761117 · EU 2026-526304-79-00
No phaseTaking people
Left Bundle Branch Area Pacing (LBBAP) PMCF Study
Where
Cona
Age
18 years and over
People
200 worldwide
Run by
Abbott Medical Devices
See details and how to joinNCT07217392
Phase 4Taking people
Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure
Where
Cagliari, Florence, Milan, Pavia, Perugia
Age
18 years to 130 years
People
60 worldwide
Run by
AstraZeneca
See details and how to joinNCT06651970
Phase 2/3Not yet taking people in Italy
Randomized Evaluation of Istaroxime for Stabilization in Acute Heart Failure-Cardiogenic Shock
Where
Brescia, Milan, Rozzano, Turin, Udine
Age
18 years to 80 years
People
600 worldwide
Run by
Seismic Pharmaceuticals Operations LLC
See details and how to joinNCT07583446 · EU 2026-527261-29-00