Heart failure trials in United States

In United States 387 Also abroad 1266

387 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 2Not yet taking people in United States
Testing Heart Failure Resilience Intervention for Caregivers (HEROIC) in Advanced Heart Failure
Where
Baltimore, Denver
Age
18 years and over
People
500
Run by
Johns Hopkins University
See details and how to joinNCT07805811
No phaseEnrolling by invitation
The Effect of Adiposity on Muscle and Microvascular Function in HFpEF
Where
Dallas
Age
18 years and over
People
95
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT06930495
No phaseTaking people
Remote Dielectric Sensing (ReDS) Assisted Diuresis in Acute Decompensated Heart Failure
Where
San Francisco
Age
18 years and over
People
100
Run by
University of California, San Francisco
See details and how to joinNCT03586336
No phaseTaking people
Right Ventricular Pacing in Pulmonary Arterial Hypertension
Where
San Francisco
Age
18 years to 75 years
People
16
Run by
University of California, San Francisco
See details and how to joinNCT04194632
No phaseTaking people
Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF
Where
Boston
Age
65 years and over
People
515
Run by
Massachusetts General Hospital
See details and how to joinNCT05577819
No phaseEnrolling by invitation
Pre-hospital Ventilation Clinical Study
Where
Baton Rouge, Fort Worth, Hartford, Rosedale, Uxbridge
People
500
Run by
Zoll Medical Corporation
See details and how to joinNCT05604430
No phaseNot yet taking people in United States
Pilot Study of Endoscopic Sleeve Gastroplasty for Obese Patients With Heart Failure and Preserved Ejection Fraction
Where
Los Angeles
Age
22 years and over
People
20
Run by
Cedars-Sinai Medical Center
See details and how to joinNCT07798219
No phaseTaking people
Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure
Where
Boston
Age
18 years and over
People
3,000
Run by
Massachusetts General Hospital
See details and how to joinNCT03480633
No phaseTaking people
Targeted Artificial Intelligence Language mOdel Recommendations for Heart Failure (TAILOR-HF)
Where
Boston
Age
18 years to 85 years
People
500
Run by
Brigham and Women's Hospital
See details and how to joinNCT07337577
No phaseNot yet taking people in United States
Integrating Values Based Communication in Heart Failure Management
Where
Louisville
Age
18 years to 105 years
People
200
Run by
Abigail Latimer
See details and how to joinNCT07794930
Phase 2Taking people
AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF
Where
Boston, Cincinnati, Dallas, Fairhope, Hialeah, Houston, Imperial, Little Rock, Milwaukee, Morristown, New York, Pasadena, Peoria, Portland, Rochester, San Francisco, Santa Maria, Seattle, Slidell, St Louis, Tucson, Vienna, Vista, Weston
Age
40 years to 85 years
People
60
Run by
Cytokinetics
See details and how to joinNCT06793371 · EU 2024-516349-38-00
No phaseTaking people
Women's Ischemia Syndrome Evaluation (WISE) Pre-HFpEF
Where
Gainesville, Los Angeles
Age
18 years and over
People
180
Run by
Cedars-Sinai Medical Center
See details and how to joinNCT03876223
No phaseTaking people
Optimizing Heart Failure Therapies Among Patients With Limited Access in Denver
Where
Denver
Age
18 years and over
People
40
Run by
Denver Health and Hospital Authority
See details and how to joinNCT07435662
No phaseTaking people
Retinal Fundus Imaging and OCT Imaging for Ocular Detection of ATTR-CM
Where
Boston, Chicago, Germantown, Jacksonville, Palo Alto, Portland
Age
18 years and over
People
500 worldwide
Run by
AstraZeneca
See details and how to joinNCT07690436
No phaseTaking people
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
Where
Abington, Anderson, Ann Arbor, Atlanta, Augusta, Brooklyn, Charlotte, Charlottesville, Chicago, Columbus, Concord, Detroit, Downers Grove, Durham, Elk Grove Village, Fort Lauderdale, Fort Worth, Hackensack, Houston, Jackson, Marietta, Murray, Neptune City, New York, Oklahoma City, Pensacola, Philadelphia, Phoenix, Plano, Portland, Poughkeepsie, Richmond, San Francisco, Scottsdale, Staten Island, Tallahassee, Tampa, Weston, Wichita, Wilmington
Age
21 years and over
People
320 worldwide
Run by
Procyrion
See details and how to joinNCT05677100
No phaseTaking people
Optimal Pediatric Heart Transplant Immunosuppression With MicroRNAs
Where
Ann Arbor, Aurora, Chicago, Houston, Nashville, New York, Pittsburgh
Age
Up to 18 years
People
150
Run by
Northwestern University
See details and how to joinNCT06532890
Phase 1Taking people
Sodium/Glucose Cotransporter-2 Inhibitors (SGLT2i) Therapy in Duchenne Cardiomyopathy
Where
Nashville
Age
8 years to 18 years
People
10
Run by
Vanderbilt University Medical Center
See details and how to joinNCT07172971
No phaseTaking people
PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fibrillation and HFpEF
Where
Chicago
Age
60 years to 99 years
People
30
Run by
Northwestern University
See details and how to joinNCT07324772
Phase 4Taking people
Incretin Therapies in Obesity-related HFpEF
Where
New York
Age
40 years and over
People
50
Run by
Columbia University
See details and how to joinNCT07554638
No phaseEnrolling by invitation
Virtual Nurse and Social Worker Palliative Care Team to Improve Quality of Life in Veterans With Heart Failure or COPD
Where
Aurora, Cheyenne, Lebanon, Long Beach, Phoenix, Providence, Shreveport
Age
18 years and over
People
420
Run by
VA Office of Research and Development
See details and how to joinNCT07714252
No phaseTaking people
WISE CVD - Continuation (WISE HFpEF)
Where
Los Angeles
Age
18 years and over
People
220
Run by
Cedars-Sinai Medical Center
See details and how to joinNCT02582021
No phaseTaking people
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Where
Albuquerque, Aurora, Austin, Baltimore, Boston, Chapel Hill, Charleston, Chicago, Cincinnati, Columbia, Dallas, Durham, Hershey, Honolulu, Houston, Indianapolis, Iowa City, Jackson, Jacksonville, Kansas City, Lebanon, Lexington, Little Rock, Los Angeles, Louisville, Madison, Milwaukee, Minneapolis, Morgantown, Nashville, New Orleans, Oklahoma City, Omaha, Palo Alto, Phoenix, Portland, Providence, Salt Lake City, Seattle, Sioux Falls, Wilmington
Age
0 years to 20 years
People
5,000 worldwide
Run by
Duke University
See details and how to joinNCT04278404
Phase 4Taking people
A Preliminary Study for INFORMED
Where
New York
Age
65 years and over
People
18
Run by
Weill Medical College of Cornell University
See details and how to joinNCT05585125
No phaseTaking people
Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF)
Where
New York
Age
18 years and over
People
1,094
Run by
Weill Medical College of Cornell University
See details and how to joinNCT06118983
No phaseEnrolling by invitation
Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways
Where
Nashville, Pasadena
Age
18 years and over
People
1,000
Run by
Peerbridge Health, Inc
See details and how to joinNCT07775976