Heart failure trials in United States

In United States 387 Also abroad 1266

387 trials · From ClinicalTrials.gov, checked 12 November 2026. Ask the study team whether a trial fits you.

Phase 2/3Taking people
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
Where
Ann Arbor, Atlanta, Aurora, Boston, Cincinnati, Cleveland, Dallas, Houston, Los Angeles, Memphis, New York, Palo Alto, Philadelphia, Pittsburgh, San Bernardino, Seattle, St Louis, St. Petersburg, The Bronx, Washington D.C.
Age
29 days to 17 years
People
342 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT05714085 · EU 2022-501238-52-00
No phaseTaking people
HEART Camp Connect -Promoting Exercise in Adults With Heart Failure With Preserved Ejection Fraction
Where
Charlottesville, Detroit, Omaha
Age
18 years and over
People
300
Run by
University of Nebraska
See details and how to joinNCT05784753
No phaseEnrolling by invitation
Multi-Scale Analysis of Phenotypes in Heart Failure (MAP-HEART)
Where
Baltimore, Falls Church
Age
18 years to 100 years
People
2,000
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT06280820
No phaseTaking people
A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
Where
Boston, Cleveland, Detroit, Houma, Manhasset, Mechanicsburg, New Haven, New York, Tucson, Tulsa, Washington D.C., Weston, Wynnewood
Age
18 years to 85 years
People
750 worldwide
Run by
Pulnovo Medical, Inc.
See details and how to joinNCT07214376
No phaseEnrolling by invitation
N-of-1 Trial to Promote Beta-Blocker Titration in Heart Failure
Where
New York
Age
50 years and over
People
50
Run by
Brigham and Women's Hospital
See details and how to joinNCT07489352
Phase 1/2Not yet taking people in United States
HiCM-188 Cell Therapy in Adults With Advanced Heart Failure Undergoing Heart Bypass Surgery
Where
Houston
Age
18 years to 75 years
People
12
Run by
HELP Therapeutics, Inc.
See details and how to joinNCT07646210
No phaseTaking people
BRIDGE Trial: Embedding Consumer-grade mHealth Technologies Into Cardiac Rehabilitation
Where
Chicago
Age
18 years and over
People
30
Run by
University of Illinois Chicago
See details and how to joinNCT07741396
No phaseTaking people
PrEcision Pacing in HFpEF: the PEP-HFpEF Trial
Where
Boston
Age
18 years and over
People
36
Run by
Tufts Medical Center
See details and how to joinNCT07864558
No phaseTaking people
Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure
Where
Boston, Chattanooga, Cincinnati, Clearwater, Elk Grove Village, Germantown, Indianapolis, Jacksonville, Kansas City, Los Angeles, Marshfield, Mobile, Moline, New York, Omaha, Orlando, Sioux Falls, Tallahassee, Tampa, Tulsa, Tyler
Age
18 years and over
People
2,500
Run by
CVRx, Inc.
See details and how to joinNCT07232030
Phase 2Not yet taking people in United States
The CARDIOPROTECT Trial
Where
Boston
Age
18 years and over
People
60
Run by
Beth Israel Deaconess Medical Center
See details and how to joinNCT07654426
Phase 2Not yet taking people in United States
A Study of Bimagrumab in Participants With HFpEF
Where
Dallas, North Miami Beach, Van Nuys
Age
18 years and over
People
540 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07920887 · EU 2026-527983-34-00
No phaseTaking people
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
Where
Abington, Albuquerque, Atlanta, Augusta, Austin, Boston, Chapel Hill, Charleston, Charlotte, Charlottesville, Chicago, Cincinnati, Cleveland, Columbia, Dallas, Detroit, Gainesville, Grand Rapids, Hackensack, Hershey, Houston, Indianapolis, Iowa City, Kansas City, Lexington, Little Rock, Louisville, Manhasset, Marietta, Memphis, Milwaukee, Minneapolis, Newark, New York, Oakbrook Terrace, Oklahoma City, Omaha, Philadelphia, Phoenix, Pittsburgh, Plano, Portland, Richmond, Rochester, Sacramento, Salt Lake City, San Francisco, Temple, The Bronx, Tulsa, Washington D.C., Weston
Age
18 years and over
People
850 worldwide
Run by
Abbott Medical Devices
See details and how to joinNCT06526195
No phaseTaking people
Using Ultromics EchoGo HFpEF Algorithm to Identify and Treat High Heart Failure Risk in Patients With Type 2 Diabetes
Where
Dallas
People
800
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT06593314
Phase 3Not yet taking people in United States
Early Discharge With Subcutaneous Furosemide Versus Standard Care in Acute Heart Failure
Where
Dallas
Age
18 years to 100 years
People
250
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT07018297
No phaseTaking people
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
Where
Ann Arbor, Columbus, Murray, New Haven, Philadelphia, Seattle, Tucson, Winston-Salem
Age
18 years and over
People
500
Run by
Ohio State University
See details and how to joinNCT07558265
No phaseTaking people
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
Where
Akron, Albuquerque, Allentown, Anchorage, Atlanta, Aurora, Austin, Bakersfield, Baltimore, Baton Rouge, Bethesda, Bethlehem, Birmingham, Boston, Bradenton, Burlington, Centennial, Chandler, Charlottesville, Chula Vista, Cincinnati, Clearwater, Cleveland, Clinton, Colorado Springs, Columbia, Columbus, Coon Rapids, Dallas, Danville, Denver, Durham, Eatontown, Edgewood, Erie, Evansville, Falls Church, Fort Worth, Germantown, Hartford, Hattiesburg, Hollywood, Houston, Huntington, Hyattsville, Indianapolis, Jacksonville, Jonesboro, Kansas City, La Jolla, Lakewood, Lancaster, Lansing, Little Rock, Los Angeles, Louisville, Madison, Manhasset, Marietta, Marlton, Marquette, Milwaukee, Minneapolis, Morristown, Mount Kisco, Nashville, New Brunswick, New Haven, New York, Ocean City, Oklahoma City, Olympia, Omaha, Palm Springs, Panama City, Philadelphia, Pittsburgh, Plano, Port Jefferson, Portland, Poughkeepsie, Raleigh, Rancho Mirage, Redwood City, Ridgewood, Robbinsdale, Rochester, Safety Harbor, Saint Cloud, Saint Paul, Salinas, Salisbury, San Diego, Sarasota, Shreveport, Silver Spring, Spokane, Stanford, St Louis, Takoma Park, Tampa, The Woodlands, Toledo, Torrance, Tyler, Utica, Van Nuys, Ventura, Washington D.C., West Des Moines, Wilkes-Barre, Ypsilanti
People
20,000 worldwide
Run by
Medtronic
See details and how to joinNCT00271180
Phase 3Taking people
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
Where
Albany, Alexander City, Atlanta, Aurora, Baltimore, Bangor, Beverly Hills, Birmingham, Boston, Bridgeport, Bridgewater, Camp Hill, Cary, Chapel Hill, Charleston, Cincinnati, Clearwater, Cleveland, Dallas, Detroit, Durham, Eatontown, El Paso, Fayetteville, Fort Lauderdale, Galveston, Germantown, Greensboro, Hartford, Hershey, Hollywood, Honolulu, Houston, Independence, Jacksonville, Kansas City, Knoxville, La Jolla, Loma Linda, Los Angeles, Manhasset, Marion, Miami Beach, Milwaukee, Munster, Murray, Naperville, Nashville, Newburgh, New Haven, New Orleans, New York, Norfolk, Ocala, Omaha, Orange, Orlando, Overland Park, Philadelphia, Plano, Portland, Poughkeepsie, Rapid City, Richmond, Sacramento, Salt Lake City, San Diego, Sandusky, San Francisco, Santa Clara, Spokane, Stanford, St Louis, Tampa, The Bronx, Torrance, Tucson, Tullahoma, Tulsa, Winston-Salem
Age
18 years to 85 years
People
1,800 worldwide
Run by
Cytokinetics
See details and how to joinNCT06736574 · EU 2024-519219-32-00
Phase 3Taking people
SWITCH: Apixaban vs Vitamin K in HM3
Where
New York
Age
18 years to 80 years
People
460
Run by
Columbia University
See details and how to joinNCT07471139
Phase 1Taking people
A Study of LY3971297 in Participants With Heart Failure
Where
Chapel Hill, Detroit, Houston, St Louis
Age
18 years to 65 years
People
90 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07547540 · EU 2026-525663-40-00
No phaseTaking people
Rehabilitation Program for People With Methamphetamine-Associated Cardiopulmonary Conditions
Where
Salt Lake City
Age
18 years and over
People
45
Run by
Michael Incze
See details and how to joinNCT07915882
No phaseNot yet taking people in United States
PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study
Where
Milwaukee
Age
18 years and over
People
60
Run by
Medical College of Wisconsin
See details and how to joinNCT05377320
No phaseTaking people
ELEVATE-HFpEF Clinical Study
Where
Albuquerque, Atlanta, Boston, Burlington, Charleston, Chicago, Columbus, Dallas, Des Moines, Durham, Falls Church, Fort Worth, Hartford, Houma, Kansas City, Lancaster, Louisville, Milwaukee, Minneapolis, Nashville, Palo Alto, Panama City, Phoenix, Plano, San Francisco, Tacoma, Wynnewood
Age
40 years and over
People
700 worldwide
Run by
Medtronic Cardiac Rhythm and Heart Failure
See details and how to joinNCT06678841
No phaseTaking people
Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure
Where
Albany, Ann Arbor, Atlanta, Charlotte, Charlottesville, Columbus, Duluth, Durham, Fall River, Flushing, Grand Rapids, Hinsdale, Huntsville, Indianapolis, Iowa City, Jonesboro, La Jolla, Los Angeles, Louisville, Meridian, Mobile, Morristown, Naperville, Nashville, New York, Oakland, Philadelphia, Phoenix, Plano, Saint Cloud, Santa Monica, Sarasota, Sioux Falls, Syracuse, Tampa, Torrance, Tyler, Ventura, Washington D.C., Wilkes-Barre
Age
18 years and over
People
850
Run by
Boston Scientific Corporation
See details and how to joinNCT07069738
No phaseNot yet taking people in United States
Importance of Point-of-Care Ultrasound for Early Detection of Valvular and Cardiac Diseases (IMPROVE)
Where
Dallas
Age
65 years to 85 years
People
1,088
Run by
University of Texas Southwestern Medical Center
See details and how to joinNCT07756398
No phaseTaking people
Evaluating a Digital Aid to Improve ICD Decisions
Where
Greenville, San Francisco
Age
60 years and over
People
600
Run by
Stanford University
See details and how to joinNCT07913204